Results 1 to 10 of about 548,676 (308)
Maladaptation and the paradox of robustness in evolution. [PDF]
PLoS ONE, 2007 Organisms use a variety of mechanisms to protect themselves against perturbations. For example, repair mechanisms fix damage, feedback loops keep homeostatic systems at their setpoints, and biochemical filters distinguish signal from noise.
Steven A Frank
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Neutral Evolution of Mutational Robustness [PDF]
Proceedings of the National Academy of Sciences, 1999 We introduce and analyze a general model of a population evolving over a network of selectively neutral genotypes. We show that the population's limit distribution on the neutral network is solely determined by the network topology and given by the ...
Babajide +19 more
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Evolution of mutational robustness in an RNA virus. [PDF]
PLoS Biology, 2005 Mutational (genetic) robustness is phenotypic constancy in the face of mutational changes to the genome. Robustness is critical to the understanding of evolution because phenotypically expressed genetic variation is the fuel of natural selection ...
Rebecca Montville +4 more
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Evolution favors protein mutational robustness in sufficiently large populations [PDF]
BMC Biology, 2007 Background An important question is whether evolution favors properties such as mutational robustness or evolvability that do not directly benefit any individual, but can influence the course of future evolution.
Venturelli Ophelia S +5 more
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Evolution of robustness to noise and mutation in gene expression dynamics. [PDF]
PLoS ONE, 2007 Phenotype of biological systems needs to be robust against mutation in order to sustain themselves between generations. On the other hand, phenotype of an individual also needs to be robust against fluctuations of both internal and external origins that ...
Kunihiko Kaneko
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Effects of ploidy and recombination on evolution of robustness in a model of the segment polarity network. [PDF]
PLoS Computational Biology, 2009 Many genetic networks are astonishingly robust to quantitative variation, allowing these networks to continue functioning in the face of mutation and environmental perturbation. However, the evolution of such robustness remains poorly understood for real
Kerry J Kim, Vilaiwan M Fernandes
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The evolution and mutational robustness of chromatin accessibility in Drosophila [PDF]
Genome Biology, 2023 Background The evolution of genomic regulatory regions plays a critical role in shaping the diversity of life. While this process is primarily sequence-dependent, the enormous complexity of biological systems complicates the understanding of the factors ...
Samuel Khodursky +7 more
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Determinative developmental cell lineages are robust to cell deaths. [PDF]
PLoS Genetics, 2014 All forms of life are confronted with environmental and genetic perturbations, making phenotypic robustness an important characteristic of life. Although development has long been viewed as a key component of phenotypic robustness, the underlying ...
Jian-Rong Yang +2 more
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PLoS Computational Biology, 2013 Gene regulatory networks show robustness to perturbations. Previous works identified robustness as an emergent property of gene network evolution but the underlying molecular mechanisms are poorly understood.
Mario Pujato +3 more
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The Synergistic Effects of Structural Evolution and Attack Strategies on Network Matching Robustness [PDF]
EntropyResearch on network robustness has long focused on changes in the structure connectivity of networks under attacks, effectively depicting structural integrity while ignoring the exploration of functional integrity.
Xu Na +4 more
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