Evolution under fluctuating environments explains observed robustness in metabolic networks. [PDF]
PLoS Computational Biology, 2010 A high level of robustness against gene deletion is observed in many organisms. However, it is still not clear which biochemical features underline this robustness and how these are acquired during evolution.
Orkun S Soyer, Thomas Pfeiffer
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Evolution of Robustness in Growing Random Networks
Entropy, 2023 Networks are widely used to model the interaction between individual dynamic systems. In many instances, the total number of units and interaction coupling are not fixed in time, and instead constantly evolve.
Melvyn Tyloo
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Evolution of drift robustness in small populations [PDF]
Nature Communications, 2017 Genetic drift can reduce fitness in small populations by counteracting selection against deleterious mutations. Here, LaBar and Adami demonstrate through a mathematical model and simulations that small populations tend to evolve to drift-robust fitness ...
Thomas LaBar, Christoph Adami
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Maladaptation and the paradox of robustness in evolution. [PDF]
PLoS ONE, 2007 Organisms use a variety of mechanisms to protect themselves against perturbations. For example, repair mechanisms fix damage, feedback loops keep homeostatic systems at their setpoints, and biochemical filters distinguish signal from noise.
Steven A Frank
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The Synergistic Effects of Structural Evolution and Attack Strategies on Network Matching Robustness [PDF]
EntropyResearch on network robustness has long focused on changes in the structure connectivity of networks under attacks, effectively depicting structural integrity while ignoring the exploration of functional integrity.
Xu Na +4 more
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Evolution of mutational robustness in an RNA virus. [PDF]
PLoS Biology, 2005 Mutational (genetic) robustness is phenotypic constancy in the face of mutational changes to the genome. Robustness is critical to the understanding of evolution because phenotypically expressed genetic variation is the fuel of natural selection ...
Rebecca Montville +4 more
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Mutational robustness changes during long-term adaptation in laboratory budding yeast populations
eLife, 2022 As an adapting population traverses the fitness landscape, its local neighborhood (i.e., the collection of fitness effects of single-step mutations) can change shape because of interactions with mutations acquired during evolution.
Milo S Johnson, Michael M Desai
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Neutral evolution of mutational robustness [PDF]
Proceedings of the National Academy of Sciences, 1999 We introduce and analyze a general model of a population evolving over a network of selectively neutral genotypes. We show that the population’s limit distribution on the neutral network is solely determined by the network topology and given by the principal eigenvector of the network’s adjacency matrix.
van Nimwegen, Erik +2 more
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Pangenome Evolution Reconciles Robustness and Instability of Rhizobial Symbiosis
mBio, 2022 Root nodulating rhizobia are nearly ubiquitous in soils and provide the critical service of nitrogen fixation to thousands of legume species, including staple crops.
Alexandra J. Weisberg +5 more
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Does mutational robustness inhibit extinction by lethal mutagenesis in viral populations? [PDF]
PLoS Computational Biology, 2010 Lethal mutagenesis is a promising new antiviral therapy that kills a virus by raising its mutation rate. One potential shortcoming of lethal mutagenesis is that viruses may resist the treatment by evolving genomes with increased robustness to mutations ...
Eamon B O'Dea +2 more
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