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Evolution of drift robustness in small populations [PDF]
Nature Communications, 2017 Genetic drift can reduce fitness in small populations by counteracting selection against deleterious mutations. Here, LaBar and Adami demonstrate through a mathematical model and simulations that small populations tend to evolve to drift-robust fitness ...
Thomas LaBar, Christoph Adami
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Evolution of Robustness in Digital Organisms [PDF]
Artificial Life, 2004 We study the evolution of robustness in digital organisms adapting to a high mutation rate. As genomes adjust to the harsh mutational environment, the mean effect of single mutations decreases, up until the point where a sizable fraction (up to 30% in many cases) of the mutations are neutral.
Jeffrey A. Edlund, Christoph Adami
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Evolution of mutational robustness in an RNA virus. [PDF]
PLoS Biology, 2005 Mutational (genetic) robustness is phenotypic constancy in the face of mutational changes to the genome. Robustness is critical to the understanding of evolution because phenotypically expressed genetic variation is the fuel of natural selection ...
Rebecca Montville +4 more
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Maladaptation and the paradox of robustness in evolution. [PDF]
PLoS ONE, 2007 Organisms use a variety of mechanisms to protect themselves against perturbations. For example, repair mechanisms fix damage, feedback loops keep homeostatic systems at their setpoints, and biochemical filters distinguish signal from noise.
Steven A Frank
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Evolution of Robustness in Growing Random Networks
Entropy, 2023 Networks are widely used to model the interaction between individual dynamic systems. In many instances, the total number of units and interaction coupling are not fixed in time, and instead constantly evolve.
Melvyn Tyloo
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PERSPECTIVE: EVOLUTION AND DETECTION OF GENETIC ROBUSTNESS [PDF]
Evolution, 2003 Robustness is the invariance of phenotypes in the face of perturbation. The robustness of phenotypes appears at various levels of biological organization, including gene expression, protein folding, metabolic flux, physiological homeostasis, development, and even organismal fitness.
J. Arjan G. M. de Visser +18 more
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Effects of ploidy and recombination on evolution of robustness in a model of the segment polarity network. [PDF]
PLoS Computational Biology, 2009 Many genetic networks are astonishingly robust to quantitative variation, allowing these networks to continue functioning in the face of mutation and environmental perturbation. However, the evolution of such robustness remains poorly understood for real
Kerry J Kim, Vilaiwan M Fernandes
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In silico genetic robustness analysis of microRNA secondary structures: potential evidence of congruent evolution in microRNA [PDF]
BMC Evolutionary Biology, 2007 Background Robustness is a fundamental property of biological systems and is defined as the ability to maintain stable functioning in the face of various perturbations.
Ni Ming +4 more
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Direct evolution of genetic robustness in microRNA [PDF]
Proceedings of the National Academy of Sciences, 2006 Genetic robustness, the invariance of the phenotype in the face of genetic perturbations, can endow the organism with reduced susceptibility to mutations. A large body of work in recent years has focused on the origins, mechanisms, and consequences of robustness in a wide range of biological systems.
Elhanan Borenstein, Eytan Ruppin
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Evolution of Robustness to Protein Mistranslation by Accelerated Protein Turnover. [PDF]
PLoS Biology, 2015 Translational errors occur at high rates, and they influence organism viability and the onset of genetic diseases. To investigate how organisms mitigate the deleterious effects of protein synthesis errors during evolution, a mutant yeast strain was ...
Dorottya Kalapis +10 more
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