Results 1 to 10 of about 5,031,134 (355)
Evolution of drift robustness in small populations [PDF]
Nature Communications, 2017 Genetic drift can reduce fitness in small populations by counteracting selection against deleterious mutations. Here, LaBar and Adami demonstrate through a mathematical model and simulations that small populations tend to evolve to drift-robust fitness ...
Thomas LaBar, Christoph Adami
doaj +8 more sources
Evolution of Robustness and Plasticity under Environmental Fluctuation: Formulation in terms of Phenotypic Variances [PDF]
J. Stat. Phys. 148 (2012) 686-704, 2013 The characterization of plasticity, robustness, and evolvability, an important issue in biology, is studied in terms of phenotypic fluctuations. By numerically evolving gene regulatory networks, the proportionality between the phenotypic variances of epigenetic and genetic origins is confirmed.
Kaneko, Kunihiko
arxiv +8 more sources
Evolution of robustness in digital organisms [PDF]
Artificial Life, 2004 We study the evolution of robustness in digital organisms adapting to a high mutation rate. As genomes adjust to the harsh mutational environment, the mean effect of single Imitations decreases, up until the point where a sizable fraction (up to 30% in ...
Adami, Christoph, Edlund, Jeffrey A.
core +8 more sources
Evolution favors protein mutational robustness in sufficiently large populations [PDF]
BMC Biology, 2007 Background An important question is whether evolution favors properties such as mutational robustness or evolvability that do not directly benefit any individual, but can influence the course of future evolution.
Venturelli Ophelia S +5 more
doaj +8 more sources
Maladaptation and the paradox of robustness in evolution. [PDF]
PLoS ONE, 2007 Organisms use a variety of mechanisms to protect themselves against perturbations. For example, repair mechanisms fix damage, feedback loops keep homeostatic systems at their setpoints, and biochemical filters distinguish signal from noise.
Steven A Frank
doaj +14 more sources
Evolution of robustness to noise and mutation in gene expression dynamics. [PDF]
PLoS ONE, 2007 Phenotype of biological systems needs to be robust against mutation in order to sustain themselves between generations. On the other hand, phenotype of an individual also needs to be robust against fluctuations of both internal and external origins that ...
Kunihiko Kaneko
doaj +8 more sources
Phenotype selection due to mutational robustness. [PDF]
PLoS ONE, 2023 The mutation-selection mechanism of Darwinian evolution gives rise not only to adaptation to environmental conditions but also to the enhancement of robustness against mutations.
Macoto Kikuchi
doaj +3 more sources
Neutral Evolution of Mutational Robustness [PDF]
Proceedings of the National Academy of Sciences, 1999 We introduce and analyze a general model of a population evolving over a network of selectively neutral genotypes. We show that the population's limit distribution on the neutral network is solely determined by the network topology and given by the ...
Babajide +19 more
core +12 more sources
Shaping Robust System through Evolution [PDF]
Chaos (2008)18, 026112, 2008 Biological functions are generated as a result of developmental dynamics that form phenotypes governed by genotypes. The dynamical system for development is shaped through genetic evolution following natural selection based on the fitness of the phenotype.
de Visser J. A. G. M. +10 more
arxiv +7 more sources
The Effect of Recombination on the Neutral Evolution of Genetic Robustness [PDF]
Mathematical Biosciences, 2008 Conventional population genetics considers the evolution of a limited number of genotypes corresponding to phenotypes with different fitness. As model phenotypes, in particular RNA secondary structure, have become computationally tractable, however, it has become apparent that the context dependent effect of mutations and the many-to-one nature ...
Albert +17 more
arxiv +6 more sources