Results 31 to 40 of about 99,185 (278)
Molecular Systems Biology, 2008 Gene expression, like many biological processes, is subject to noise. This noise has been measured on a global scale, but its general importance to the fitness of an organism is unclear.
Ben Lehner
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EvoRSR: an integrated system for exploring evolution of RNA structural robustness
BMC Bioinformatics, 2009 Background Robustness, maintaining a constant phenotype despite perturbations, is a fundamental property of biological systems that is incorporated at various levels of biological complexity.
Ni Ming +4 more
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Determinative developmental cell lineages are robust to cell deaths. [PDF]
PLoS Genetics, 2014 All forms of life are confronted with environmental and genetic perturbations, making phenotypic robustness an important characteristic of life. Although development has long been viewed as a key component of phenotypic robustness, the underlying ...
Jian-Rong Yang +2 more
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Evolution favors protein mutational robustness in sufficiently large populations
BMC Biology, 2007 Background An important question is whether evolution favors properties such as mutational robustness or evolvability that do not directly benefit any individual, but can influence the course of future evolution.
Venturelli Ophelia S +5 more
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Shaping robust system through evolution [PDF]
Chaos: An Interdisciplinary Journal of Nonlinear Science, 2008 Biological functions are generated as a result of developmental dynamics that form phenotypes governed by genotypes. The dynamical system for development is shaped through genetic evolution following natural selection based on the fitness of the phenotype.
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Robustness and plasticity in network evolution [PDF]
Nature Reviews Genetics, 2012 This study describes a new computational approach for studying the evolutionary rewiring of transcriptional regulatory networks by changes in the targets of transcription factors. By applying the approach to the study of 88 transcription factor target binding motifs in 23 species of ascomycete fungi, the authors found that although the biological ...
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Evolution of dominance in gene expression pattern associated with phenotypic robustness
BMC Ecology and Evolution, 2021 Background Mendelian inheritance is a fundamental law of genetics. When we consider two genomes in a diploid cell, a heterozygote’s phenotype is dominated by a particular homozygote according to the law of dominance.
Kenji Okubo, Kunihiko Kaneko
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Evolutionary Bioinformatics, 2011 In the evolutionary process, the random transmission and mutation of genes provide biological diversities for natural selection. In order to preserve functional phenotypes between generations, gene networks need to evolve robustly under the influence of ...
Bor-Sen Chen, Ying-Po Lin
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Population Ecology, EarlyView.Population size and dynamics fundamentally shape speciation by influencing genetic drift, founder events, and adaptive potential. Small populations may speciate rapidly due to stronger drift, whereas large populations harbor more genetic diversity, which can alter divergence trajectories. We highlight theoretical models that incorporate population size
Ryo Yamaguchi +3 more
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Upstream plasticity and downstream robustness in evolution of molecular networks
BMC Evolutionary Biology, 2004 Background Gene duplication followed by the functional divergence of the resulting pair of paralogous proteins is a major force shaping molecular networks in living organisms.
Eriksen Kasper +3 more
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