Results 31 to 40 of about 548,676 (308)
Molecular Systems Biology, 2008 Gene expression, like many biological processes, is subject to noise. This noise has been measured on a global scale, but its general importance to the fitness of an organism is unclear.
Ben Lehner
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Evolution of Robustness to Protein Mistranslation by Accelerated Protein Turnover. [PDF]
PLoS Biology, 2015 Translational errors occur at high rates, and they influence organism viability and the onset of genetic diseases. To investigate how organisms mitigate the deleterious effects of protein synthesis errors during evolution, a mutant yeast strain was ...
Dorottya Kalapis +10 more
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Idealised simulations of cyclones with robust symmetrically-unstable sting jets [PDF]
, 2020 Idealised simulations of Shapiro-Keyser cyclones developing a sting jet (SJ) are presented. Thanks to an improved and accurate implementation of thermal wind balance in the initial state, it has been possible to use more realistic environments than in ...
Clark, Peter A. +2 more
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Survival and innovation: The role of mutational robustness in evolution [PDF]
Biochimie, 2014 Biological systems are resistant to perturbations caused by the environment and by the intrinsic noise of the system. Robustness to mutations is a particular aspect of robustness in which the phenotype is resistant to genotypic variation. Mutational robustness has been linked to the ability of the system to generate heritable genetic variation (a ...
Mario A. Fares
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Recombination and the evolution of mutational robustness
Journal of Theoretical Biology, 2006 Mutational robustness is the degree to which a phenotype, such as fitness, is resistant to mutational perturbations. Since most of these perturbations will tend to reduce fitness, robustness provides an immediate benefit for the mutated individual. However, robust systems decay due to the accumulation of deleterious mutations that would otherwise have ...
Gardner, A, Kalinka, A
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The Evolution of Variability and Robustness in Neural Development [PDF]
Trends in Neurosciences, 2018 As in all biological systems, neurons and their networks must balance precision with variability. Phenotypic precision and phenotypic variability can both occur with remarkable robustness, where robustness is defined as the ability to tolerate perturbation.
P. Robin Hiesinger, Bassem A. Hassan
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Direct evolution of genetic robustness in microRNA [PDF]
Proceedings of the National Academy of Sciences, 2006 Genetic robustness, the invariance of the phenotype in the face of genetic perturbations, can endow the organism with reduced susceptibility to mutations. A large body of work in recent years has focused on the origins, mechanisms, and consequences of robustness in a wide range of biological systems.
Elhanan, Borenstein, Eytan, Ruppin
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Evolution of Robustness and Plasticity under Environmental Fluctuation: Formulation in terms of Phenotypic Variances [PDF]
, 2012 The characterization of plasticity, robustness, and evolvability, an important issue in biology, is studied in terms of phenotypic fluctuations. By numerically evolving gene regulatory networks, the proportionality between the phenotypic variances of ...
Kaneko, Kunihiko
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Shaping robust system through evolution [PDF]
Chaos: An Interdisciplinary Journal of Nonlinear Science, 2008 Biological functions are generated as a result of developmental dynamics that form phenotypes governed by genotypes. The dynamical system for development is shaped through genetic evolution following natural selection based on the fitness of the phenotype.
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Degeneracy: a design principle for achieving robustness and evolvability
, 2009 Robustness, the insensitivity of some of a biological system's functionalities to a set of distinct conditions, is intimately linked to fitness. Recent studies suggest that it may also play a vital role in enabling the evolution of species.
Bender, Axel, Whitacre, James M
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