Results 31 to 40 of about 567,669 (271)
Evolution favors protein mutational robustness in sufficiently large populations
BMC Biology, 2007 Background An important question is whether evolution favors properties such as mutational robustness or evolvability that do not directly benefit any individual, but can influence the course of future evolution.
Venturelli Ophelia S +5 more
doaj +1 more source
Determinative developmental cell lineages are robust to cell deaths. [PDF]
PLoS Genetics, 2014 All forms of life are confronted with environmental and genetic perturbations, making phenotypic robustness an important characteristic of life. Although development has long been viewed as a key component of phenotypic robustness, the underlying ...
Jian-Rong Yang +2 more
doaj +1 more source
Quantum computing of delocalization in small-world networks [PDF]
, 2005 We study a quantum small-world network with disorder and show that the system exhibits a delocalization transition. A quantum algorithm is built up which simulates the evolution operator of the model in a polynomial number of gates for exponential number
B. Georgeot +5 more
core +3 more sources
Evolution of dominance in gene expression pattern associated with phenotypic robustness
BMC Ecology and Evolution, 2021 Background Mendelian inheritance is a fundamental law of genetics. When we consider two genomes in a diploid cell, a heterozygote’s phenotype is dominated by a particular homozygote according to the law of dominance.
Kenji Okubo, Kunihiko Kaneko
doaj +1 more source
Degeneracy: a design principle for achieving robustness and evolvability
, 2009 Robustness, the insensitivity of some of a biological system's functionalities to a set of distinct conditions, is intimately linked to fitness. Recent studies suggest that it may also play a vital role in enabling the evolution of species.
Bender, Axel, Whitacre, James M
core +1 more source
Upstream plasticity and downstream robustness in evolution of molecular networks
BMC Evolutionary Biology, 2004 Background Gene duplication followed by the functional divergence of the resulting pair of paralogous proteins is a major force shaping molecular networks in living organisms.
Eriksen Kasper +3 more
doaj +1 more source
Observation of a localized flat-band state in a photonic Lieb lattice [PDF]
, 2015 We show experimentally how a non-diffracting state can be excited in a photonic Lieb lattice. This lattice supports three energy bands, including a perfectly flat middle band, which corresponds to an infinite effective mass with zero dispersion.
Andersson, Erika +6 more
core +2 more sources
Direct evolution of genetic robustness in microRNA [PDF]
Proceedings of the National Academy of Sciences, 2006 Genetic robustness, the invariance of the phenotype in the face of genetic perturbations, can endow the organism with reduced susceptibility to mutations. A large body of work in recent years has focused on the origins, mechanisms, and consequences of robustness in a wide range of biological systems.
Elhanan, Borenstein, Eytan, Ruppin
openaire +2 more sources
Neutral Evolution of Robustness in Drosophila microRNA Precursors [PDF]
Molecular Biology and Evolution, 2011 Mutational robustness describes the extent to which a phenotype remains unchanged in the face of mutations. Theory predicts that the strength of direct selection for mutational robustness is at most the magnitude of the rate of deleterious mutation. As far as nucleic acid sequences are concerned, only long sequences in organisms with high deleterious ...
Price, N +4 more
openaire +2 more sources
Implementing Health‐Related Quality of Life Assessment in Pediatric Oncology: A Feasibility Study
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background There is growing interest in embedding health‐related quality of life (HRQoL) assessment and patient‐reported outcome measures (PROMs) within clinical cancer care. This study evaluated the feasibility, acceptability, and usability of implementing an electronic PROM (ePROM) platform to measure HRQoL in children with cancer ...
Mikaela Doig +13 more
wiley +1 more source