Results 101 to 110 of about 1,366,518 (256)

Analytical Models for Secular Descents in Hierarchical Triple Systems

open access: yesThe Astrophysical Journal
Three-body systems are prevalent in nature, from planetary to stellar to supermassive black hole scales. In a hierarchical triple system, oscillations of the inner orbit’s eccentricity and inclination can be induced on secular timescales.
Grant C. Weldon   +2 more
doaj   +1 more source

Prodromal Lewy Body Disorder Features in REM Sleep Behavior Disorder With Biomarker‐Defined Synucleinopathy

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Isolated rapid eye movement sleep behavior disorder (iRBD) is a prodromal state for Lewy body disorders and exhibits biological heterogeneity that may influence clinical expression and progression. We examined clinical features in individuals with iRBD and biomarker‐defined synucleinopathy.
Daniel Weintraub   +24 more
wiley   +1 more source

Sertraline Treatment Can Mimic Niemann‐Pick Type C Biomarker Profile: A Diagnostic Pitfall

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Oxysterols (cholestane‐3β,5α,6β‐triol and 7‐ketocholesterol) and N‐palmitoyl‐O‐phosphocholineserine (PPCS) are sensitive biomarkers for Niemann‐Pick disease type C (NPC) screening. However, false‐positive results occur, with a biomarker profile suggestive of NPC despite the absence of pathogenic variants in genes involved in NPC or ...
Maria Makrygianni   +19 more
wiley   +1 more source

Brief von Karl von La Roche an Unbekannt

open access: yes, 1878
BRIEF VON KARL VON LA ROCHE AN UNBEKANNT Brief von Karl von La Roche an Unbekannt ...
La Roche, Karl von
core   +1 more source

Replication data for: "Taking Innovation to the Streets: Micro-geography, Physical Structure and Innovation"

open access: yes
Roche, Maria P., (2020) “Taking Innovation to the Streets: Microgeography, Physical Structure, and Innovation.” Review of Economics and Statistics 102:5, 912 ...
Roche, Maria
core   +1 more source

Association Between Motor Pathway Damage and Motor Deficit in Upper and Lower Limb in People With MS

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Corticospinal tract damage is common in people with MS, but the degree of clinical symptoms varies. We hypothesize that corticospinal tract lesions are more extensive and severe in people with MS with motor impairments in both upper and lower limbs.
Mathilde Liffran   +13 more
wiley   +1 more source

Memo from Kate Roche, Box Office Manager, to Cast & Crew [PDF]

open access: yes, 1999
Providence College Department of Theatre, Dance & Film Memo from Kate Roche, Box Office Manager, to cast & crew regarding tickets to Tartuffe.
Roche, Kate
core   +1 more source

Big data variety & veracity: the roche preclinical warehouse

open access: yes, 2016
Often big data is associated with high volume and high velocity but when it comes to preclinical drug discovery the variety and veracity aspect is critical.The ROCHE preclinical data warehouse gathers 300M results covering more than 4'500 different ...
O. Roche (5200840), O. Roche
core   +1 more source

Efficacy of Inebilizumab in N‐MOmentum Trial Participants With or Without Prior Immunosuppressants

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT This post hoc analysis examined the impact of prior immunosuppressants on the long‐term efficacy and safety of inebilizumab, a cluster of differentiation 19+ B‐cell–depleting monoclonal antibody, in participants with aquaporin‐4–seropositive neuromyelitis optica spectrum disorder from the N‐MOmentum trial (NTC02200770).
Bruce A. C. Cree   +9 more
wiley   +1 more source

Onasemnogene Abeparvovec in Patients With SMA: Interim Results of the RESTORE Registry in Japan

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective There are limited real‐world data regarding the safety and effectiveness of onasemnogene abeparvovec (OA; Zolgensma) infusion, a one‐time gene replacement therapy, for Japanese patients with spinal muscular atrophy (SMA). We aimed to improve understanding of the real‐world outcomes for OA in Japan.
Kayoko Saito   +8 more
wiley   +1 more source

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