Results 231 to 240 of about 1,366,518 (256)

Slc44a2 Deficiency Unveils an IFN‐I–Dependent Feedback Control of pDC Egress

Advanced Science, EarlyView.
Working model of SLC44A2‐mediated maintenance of pDC homeostasis. This model illustrates two central mechanisms by which SLC44A2 regulates pDC homeostasis: (1) SLC44A2 limits IFN‐I production by exporting amino acids (T, N, Q), thereby preventing spontaneous pDC activation.
Ruiqun Chen, Tao Wu, Zhen Shi, Ravi Kumar Verma, Linlin Sheng, Lei Tao, Mingming Yang, Yuchen Wang, Conggang Zhang, Hao Fan, Li Wu, Ligong Chen   +11 more
wiley   +1 more source

AR and Beyond: ctDNA Maps Resistance Evolution in mCRPC. [PDF]

Clin Cancer Res
Chauhan PS, Pachynski RK, Maher CA, Chaudhuri AA.   +3 more
europepmc   +1 more source

PRMT5‐Dependent Stabilization of VPS34 Orchestrates Copper Trafficking to Shield Cancer Cells from Cuproptosis and Radiotherapy

Advanced Science, EarlyView.
Radioresistance arises partly from tumor cells evading cuproptosis via unknown defenses. This study reveals that the PRMT5‐VPS34 axis acts as a radiation‐activated anticuproptotic mechanism: PRMT5 methylates VPS34 at Arg174, recruiting USP10 to remove K48‐linked ubiquitination and prevent degradation.
Wei Chen, Ming‐Ying Xiao, Lan‐Lan Guo, Hao‐Yue Hu, Sui‐Xian Zhang, Bai‐Qiang Dong, Chen‐Fei Wu, Xia‐Hang Huang, Li Li, Run‐Zhe Chen, Yuan‐Yang Huang, Ying Jin, Hai Song, Ying Wang, Qi‐Wen Li, Ming Chen, Xuan Li, Yuan‐Yuan Chen   +17 more
wiley   +1 more source

Early Rule Out of Myocardial Infarction With a Novel High-Sensitivity Cardiac Troponin T Assay.

JAMA Cardiol
Thurston AJF, Tew YY, Lopez-Ayala P, Koechlin L, O'Brien R, Lynch S, Cooper JG, Fujisawa T, Bima P, McDermott M, Tuck C, Mizerska M, Highton-Williamson E, McCurrach F, Lowry MTH, Doudesis D, Anand A, Lee KK, Ferry AV, Chapman A, Newby DE, Boeddinghaus J, Mueller C, Gray AJ, Mills NL, POC-ET and APACE Investigators.   +25 more
europepmc   +1 more source

Efficacy and safety of ulcerative colitis therapies do not differ by age: A post hoc analysis of randomized controlled trials. [PDF]

Inflamm Bowel Dis
Wong ECL, Marshall JK, Ma C, Jairath V, Reinisch W, Narula N.   +5 more
europepmc   +1 more source

Long-Term Ravulizumab Efficacy and Safety in AQP4 Antibody-Positive Neuromyelitis Optica Spectrum Disorder: Final CHAMPION-NMOSD Results. [PDF]

Neurol Neuroimmunol Neuroinflamm
Pittock SJ, Barnett MH, Bennett JL, Berthele A, de Sèze J, Levy M, Nakashima I, Oreja-Guevara C, Palace J, Paul F, Pozzilli C, Pathak R, Allen K, Parks B, Kim HJ.   +14 more
europepmc   +1 more source

Joint statement from GOLD/GLI regarding the use of spirometry to define airflow obstruction and diagnose COPD. [PDF]

Eur Respir J
Halpin DMG, Stanojevic S, McCormack MC, Singh D, Kaminsky DA, Vogelmeier CF, Gochicoa-Rangel L, Agusti A, Cooper B.   +8 more
europepmc   +1 more source

Age- and Sex-Specific Reference Intervals for TSH, FT4, and FT3 Derived from the Turkish Multi-Center Cohort. [PDF]

Diagnostics (Basel)
Kiren G, Yılmaz Çalık G, Güngören M, Çubukçu HC.   +3 more
europepmc   +1 more source

Comparative efficacy of zanubrutinib plus obinutuzumab versus last prior treatment in relapsed/refractory follicular lymphoma: growth modulation index analysis from the ROSEWOOD study. [PDF]

ESMO Open
Trotman J, Bouabdallah K, Bijou F, Šálek D, de Oliveira AC, Song Y, Kingsley EC, Flowers CR, Liao S, Huang S, Shah N, Dumartin L, Zinzani PL.   +12 more
europepmc   +1 more source

Correction to: Filling the sustainability gap: what beef industry stakeholders can learn from ranchers on new practice adoption, grazing management plans, and sustainability. [PDF]

Transl Anim Sci
europepmc   +1 more source