Results 111 to 120 of about 6,500 (214)
Therapeutic Evaluation of the Suprachoroidal Space for Stem Cell Delivery in Retinal Degeneration
Stem Cells International, Volume 2026, Issue 1, 2026.The route of administration is a crucial determinant of the success of stem cell‐based therapies, especially in intraocular applications. It significantly influences therapeutic outcomes and the risk of adverse events. We aimed to evaluate the utility of the suprachoroidal space (SCS) as a delivery route for human embryonic stem cell‐derived ...
Hyun Hee Seo +5 more
wiley +1 more source
Adaptive genomic evolution of opsins reveals that early mammals flourished in nocturnal environments
BMC Genomics, 2018 Background Based on evolutionary patterns of the vertebrate eye, Walls (1942) hypothesized that early placental mammals evolved primarily in nocturnal habitats. However, not only Eutheria, but all mammals show photic characteristics (i.e.
Rui Borges +5 more
doaj +1 more source
The transcription factor GTF2IRD1 regulates the topology and function of photoreceptors by modulating photoreceptor gene expression across the retina [PDF]
, 2014 The mechanisms that specify photoreceptor cell-fate determination, especially as regards to short-wave-sensitive (S) versus medium-wave-sensitive (M) cone identity, and maintain their nature and function, are not fully understood.
Berlinicke, Cindy +11 more
core +2 more sources
The appearance of rod opsin during monkey retinal development.
Investigative ophthalmology & visual science, 1996 To determine the temporal and spatial pattern of rod opsin appearance in Macaca monkey retina.Frozen sections from fetal day (Fd) 55 to adulthood (birth = Fd168) containing the entire horizontal meridian were stained using Rho4D2 monoclonal antiserum visualized with immunofluorescent labeling.
E M, Dorn +2 more
openaire +1 more source
The Mongolian gerbil as an advanced model to study cone system physiology
Frontiers in Cellular NeuroscienceIn this work, we introduce a diurnal rodent, the Mongolian gerbil (Meriones unguiculatus) (MG) as an alternative to study retinal cone system physiology and pathophysiology in mice.
Alexander Günter +3 more
doaj +1 more source
BMC Biology, 2018 Background Intrinsically photosensitive retinal ganglion cells (ipRGCs) drive an array of non-image-forming (NIF) visual responses including circadian photoentrainment and the pupil light reflex.
Edward A. Hayter, Timothy M. Brown
doaj +1 more source
Calnexin is not essential for mammalian rod opsin biogenesis.
Molecular vision, 2009 Misfolding mutations in rod opsin are a major cause of the inherited blindness retinitis pigmentosa. Therefore, understanding the role of molecular chaperones in facilitating rod opsin biogenesis and the response to mutant rod opsin is important for retinal disease and fundamental retinal cell biology.
Maria, Kosmaoglou, Michael E, Cheetham
openaire +1 more source
Genetic control of photoreceptor terminal differentiation in Drosophila melanogaster [PDF]
, 2018 Why do photoreceptors differentiate in the eye? Though simple, biologically this is an important question, and it may prove complex to answer. To present a bigger picture: animals have evolved a diversity of highly specialised sensory organs, which they ...
Bernardo-Garcia, F. Javier +1 more
core
Blue cone monochromacy: visual function and efficacy outcome measures for clinical trials.
PLoS ONE, 2015 BackgroundBlue Cone Monochromacy (BCM) is an X-linked retinopathy caused by mutations in the OPN1LW / OPN1MW gene cluster, encoding long (L)- and middle (M)-wavelength sensitive cone opsins.
Xunda Luo +13 more
doaj +1 more source
PLoS Medicine, 2006 BackgroundRPE65 is specifically expressed in the retinal pigment epithelium and is essential for the recycling of 11-cis-retinal, the chromophore of rod and cone opsins.
Alexis-Pierre Bemelmans +8 more
doaj +1 more source