Results 201 to 210 of about 6,619 (214)

Embryonic appearance of rod opsin in the urodele amphibian eye

Roux's Archives of Developmental Biology, 1993
Notophthalmus (Triturus) viridescens, a urodele amphibian (newt) common to the Eastern United States, is a promising subject for developmental and regeneration studies. We have available a monoclonal antibody shown to be specific in many vertebrates for rod opsin, the membrane apoprotein of the visual pigment rhodopsin.
David Stephen, McDevitt, Samir Kumar, Brahma, Jean-Claude, Jeanny   +2 more
openaire   +2 more sources

Rod phototransduction in transgenic mice expressing a mutant opsin gene

Journal of the Optical Society of America A, 1996
Rod-mediated electroretinograms (ERG's) were recorded from transgenic mice expressing a mouse opsin gene with three point mutations (V20G, P23H, and P27L; termed VPP mice) and from normal littermates. The leading edge of the alpha wave was analyzed in relation to a computational model of rod phototransduction [J. Physiol.
Y, Goto, N S, Peachey, N E, Ziroli, W H, Seiple, C, Gryczan, D R, Pepperberg, M I, Naash   +6 more
openaire   +2 more sources

Circadian rhythm and light regulate opsin mRNA in rod photoreceptors

Nature, 1989
Disk membranes in the outer segment of rod photoreceptors are continuously renewed, being assembled at the outer segment base, displaced outward by new disks and eventually shed at the tip. In lower vertebrates, disk assembly occurs with a diurnal rhythm with 2-4% of the outer segment length produced daily.
J I, Korenbrot, R D, Fernald
openaire   +2 more sources

Isolation and coding sequence of the rat rod opsin gene

Journal of Molecular Neuroscience, 1994
The phototransduction cascade in vertebrate rod and cone photoreceptors is initiated by a light-induced conformational change in the visual pigment rhodopsin. The visual pigments are members of the seven-transmembrane domain, G-protein coupled receptor superfamily and consist of an apoprotein, opsin, and a chromophore, 11-cis-retinal.
C J, Barnstable, M A, Morabito
openaire   +2 more sources

Structure and evolution of the Teleost extraretinal rod‐like opsin (errlo) and ocular rod opsin (rho) genes: Is teleost rho a retrogene?

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, 2003
AbstractIn Teleost fish examined to date the ocular rod opsin gene, rho, is intronless, unlike the rod opsin genes of other vertebrate classes which possess a five exon/four intron structure. We have examined in silico the structure of rho (which is expressed uniquely in the retina) and the closely related extraretinal rod‐like opsin (exo‐rhodopsin ...
Bellingham, James, Tarttelin, Emma E., Foster, Russell G., Wells, Dominic J.   +3 more
openaire   +3 more sources

Codistribution of S-antigen and opsin in light-adapted retinal rods

Documenta Ophthalmologica, 1986
The localization of S-antigen in ultra-cryosections of rat retina has been studied and compared with that of opsin by immunoelectron microscopy. Monospecific antisera to both proteins, and Protein A-coated gold particles of two sizes were used for (double) labeling.
R M, Broekhuyse, E D, Kuhlmann, L J, Leunissen, H M, van de Scheur, A J, Verkleij   +4 more
openaire   +2 more sources

Development of a Cellular Model of Rod Opsin Retinitis Pigmentosa

2011
A cellular model was developed to investigate potential mechanisms of cell death in rod opsin retinitis pigmentosa (RP). This model is based on transient expression of the WT and mutant P23H rod opsin in human retinal pigmented epithelial cells (RPE). Cells expressing mutant P23H opsin, unlike those expressing WT opsin, have altered opsin trafficking ...
Matthew, Adamowicz, Antonius, Song, Samuel, Wadsworth, Abraham, Scaria, Catherine, O'Riordan   +4 more
openaire   +2 more sources

Molecular cloning of a rod opsin cDNA from the skate retina

Gene, 1997
Skates (Raja erinacea and R. ocellata) are among the few animals that have an exclusively rod retina. However, skate rods are unusual in that they are capable of adapting to extremely high levels of illumination that initially saturate the rod photocurrent.
J, O'Brien, H, Ripps, M R, Al-Ubaidi
openaire   +2 more sources

Evolutionarily conserved and divergent regulatory sequences in the fish rod opsin promoter

Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, 2005
Fish have multiple types and subtypes of opsin genes that are expressed in a highly regulated manner in retinal photoreceptor cells. In the rod opsin proximal promoter region (RPPR) of zebrafish (Danio rerio), the BAT 1 regulatory region contains highly conserved OTX (GATTA) and OTX-like (TATTA) sequences that can be recognized by the mammalian cone ...
Shoji, Kawamura, Kumiko, Takeshita, Taro, Tsujimura, Satoshi, Kasagi, Yoshifumi, Matsumoto   +4 more
openaire   +2 more sources

Mechanism of Transient Dark Activity of 13-Desmethylretinal/Rod Opsin Complex

Journal of the American Chemical Society, 1998
We report the studies employing 11-cis-13-desmethylretinal (13dm) 1, its dihydro analogue 2H13dm 2, and 11-cis sixmembered ring-locked analogue ret6 3, to clarify the mechanism of dark activity of the 13-desmethylretinal/rod opsin complex. Rhodopsin (Rh) is composed of a retinal chromophore linked to Lys 296 of the apoprotein opsin via a protonated ...
Qiang Tan, Koji Nakanishi, Rosalie K. Crouch   +2 more
openaire   +1 more source