Results 21 to 30 of about 6,619 (214)
Chromenone derivatives as novel pharmacological chaperones for retinitis pigmentosa-linked rod opsin mutants [PDF]
Human Molecular Genetics, 2022 ABSTRACTThe correct expression of folded, functional rhodopsin (Rho) is critical for visual perception. However, this seven-transmembrane helical G protein-coupled receptor (GPCR) is prone to mutations with pathological consequences of retinal degeneration in retinitis pigmentosa (RP) due to Rho misfolding. Pharmacological chaperones that stabilize the
Joseph T. Ortega +5 more
+6 more sources
Identification of additional outer segment targeting signals in zebrafish rod opsin [PDF]
Journal of Cell Science, 2021 ABSTRACT In vertebrate photoreceptors, opsins are highly concentrated in a morphologically distinct ciliary compartment known as the outer segment (OS). Opsin is synthesized in the cell body and transported to the OS at a remarkable rate of 100 to 1000 molecules per second.
Xiaoming Fang +3 more
openaire +2 more sources
Measurement of Single Apo-opsin Activity in a Rod Photoreceptor Cell
Seibutsu Butsuri, 2020 Shinya Sato
openalex +3 more sources
Molecular evidence that only two opsin subfamilies, the blue light- (SWS2) and green light-sensitive (RH2), drive color vision in Atlantic cod (Gadus morhua). [PDF]
PLoS ONE, 2014 Teleosts show a great variety in visual opsin complement, due to both gene duplication and gene loss. The repertoire ranges from one subfamily of visual opsins (scotopic vision) including rod opsin only retinas seen in many deep-sea species to multiple ...
Ragnhild Valen +4 more
doaj +1 more source
Light-dependent Activation of Rod Transducin by Pineal Opsin [PDF]
Journal of Biological Chemistry, 1998 The pineal gland expresses a unique member of the opsin family (P-opsin; Max, M., McKinnon, P. J., Seidenman, K. J., Barrett, R. K., Applebury, M. L., Takahashi, J. S., and Margolskee, R. F. (1995) Science 267, 1502-1506) that may play a role in circadian entrainment and photo-regulation of melatonin synthesis. To study the function of this protein, an
M, Max +4 more
openaire +2 more sources
Activation of Transducin by Bistable Pigment Parapinopsin in the Pineal Organ of Lower Vertebrates. [PDF]
PLoS ONE, 2015 Pineal organs of lower vertebrates contain several kinds of photosensitive molecules, opsins that are suggested to be involved in different light-regulated physiological functions. We previously reported that parapinopsin is an ultraviolet (UV)-sensitive
Emi Kawano-Yamashita +5 more
doaj +1 more source
Switch in rod opsin gene expression in the European eel, Anguilla anguilla (L.)
Proceedings of the Royal Society of London. Series B: Biological Sciences, 1998 The rod photoreceptors of the European eel, Anguilla anguilla (L.), alter their wavelength of maximum sensitivity (lambda max) from c.a. 523 nm to c.a. 482 nm at maturation, a switch involving the synthesis of a new visual pigment protein (opsin) that is inserted into the outer segments of existing rods.
Andrew Hope +2 more
openalex +5 more sources
Restoration of vision with ectopic expression of human rod opsin [PDF]
The Lancet, 2015 Many retinal dystrophies result in photoreceptor loss, but the inner retinal neurons can survive, making them potentially amenable to emerging optogenetic therapies. Here, we show that ectopically expressed human rod opsin, driven by either a non-selective or ON-bipolar cell-specific promoter, can function outside native photoreceptors and restore ...
Jasmina Cehajic-Kapetanovic +8 more
openaire +2 more sources
Cell Death and Disease, 2022 Mutations in TUB-like protein 1 (TULP1) are associated with severe early-onset retinal degeneration in humans. However, the pathogenesis remains largely unknown. There are two homologous genes of TULP1 in zebrafish, namely tulp1a and tulp1b.
Danna Jia +16 more
doaj +1 more source
Bat eyes have ultraviolet-sensitive cone photoreceptors. [PDF]
PLoS ONE, 2009 Mammalian retinae have rod photoreceptors for night vision and cone photoreceptors for daylight and colour vision. For colour discrimination, most mammals possess two cone populations with two visual pigments (opsins) that have absorption maxima at short
Brigitte Müller +5 more
doaj +1 more source