Molecular bases of circadian magnesium rhythms across eukaryotes
FEBS Letters, EarlyView.Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley +1 more source
Metode Pembelajaran dengan Bermain Peran dalam Pendidikan Triase untuk Mahasiswa Keperawatan
Citra Delima, 2019 The nursing profession requires scientific knowledge, technical abilities and skills. Choosing the right and best teaching method is the most important step in the education process.
Leli Rezky Dwi Oktavia, Wiwik Kusumawati
doaj +1 more source
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Penerapan Metode Role Playing untuk Meningkatkan Hasil Belajar IPS Siswa Kelas V SD Negeri 101 Kecamatan Payung Sekaki Pekanbaru [PDF]
, 2016 The problem in this research is the lack of IPS students' learning achievement, as seen from the average value of students is 71.10. Of the 33 students who achieve grades above KKM just 16 students (48.50%), while students who have not reached the KKM ...
Antosa, Z. (Zariul) +2 more
core
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Keefektifan metode role playing terhadap keaktifan dan kerja sama siswa dalam pembelajaran IPS
Harmoni Sosial: Jurnal Pendidikan IPS, 2018 Penelitian ini bertujuan untuk mengungkapkan keefektifan metode role playing dibandingkan dengan metode ceramah dalam peningkatan: (a) keaktifan siswa dan (b) kerja sama siswa dalam pembelajaran IPS kelas VIII di SMP Negeri 1 Marioriawa.
Risva Anggriani, Ishartiwi Ishartiwi
doaj +1 more source
Usando role playing na integração do conhecimento no processo ensino-aprendizagem em enfermagem: avaliação dos alunos [PDF]
, 2010 To assess role-playing as a methodology in the teaching-learning process for the Nursing Degree. To identify the attitude of nursing students towards role-playing. To analyze the response of students to their teaching-learning process after role-playing.
Cibanal Juan, Luis +2 more
core +3 more sources
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Understanding Computer Role-Playing Games: A Genre Analysis Based on Gameplay Features in Combat Systems [PDF]
, 2013 A game genre as diverse as that of computer role-playing games is difficult to overview. This poses challenges or both developers and researchers to position their work clearly within the genre.
Björk, Staffan +1 more
core +3 more sources