CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Civil Society and Conflict Transformation in Abkhazia, Israel/Palestine, Nagorno-Karabakh, Transnistria and Western Sahara [PDF]
The paper describes and analyses the role of civil society in five conflict cases – Abkhazia, Nagorno-Karabakh, Transnistria, Western Sahara and Israel/ Palestine. It evaluates the relative effectiveness of civil society organisations (CSOs) and assesses
Nona Mikhelidze, Nicoletta Pirozzi
core
Community Conserved Areas in Northeast India and Their Role in Addressing Human-Wildlife Conflict
Integration of local communities in nature/wildlife conservation is increasing, and the emergence of “Community-Conserved Areas” or CCAs in recent times is a testimony to that.
Aiyadurai, Ambika, Banerjee, Sayan
core +1 more source
Cumulative Lifetime Violence, Gender Role Conflict, and Cardiovascular Disease Risk in Eastern Canadian Men. [PDF]
Am J Mens Health, 2023 Scott-Storey K +4 more
europepmc +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
The Global Dimensions of Conflict in Sri Lanka [PDF]
This paper seeks to identify and chart the global dimensions of the political conflict and civil war in Sri Lanka. The global dimensions are visualised in terms of the ways in which the dynamic of the conflict has been embedded within two parallel and ...
Rajesh Venugopal
core
Role conflict, job crafting, stress and resilience among nurses during COVID-19. [PDF]
J Conting Crisis Manag, 2022 Sahay S, Gigliotti RA, Dwyer M.
europepmc +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Religion, Psychiatric Symptoms, and Gender Role Conflict Among Incarcerated Black Men. [PDF]
Psychol Men Masc, 2023 Thorpe S +4 more
europepmc +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source