Results 101 to 110 of about 5,045,501 (353)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Identify the challenges of leadership in hospitals
Armaghane Danesh Bimonthly Journal, 2022 Background & aim: By accepting the responsibility of management and leadership, doctors are not completely separated from their medical duties. Usually, doctors have to follow their therapeutic duties while playing the role of leadership.
M Kabiri Naeini, H Jamali, Z Elahi
doaj
Conflicting Roles for p63 in Skin Development and Carcinogenesis [PDF]
, 2007 Maranke I. Koster +2 more
openalex +1 more source
Conflict Experiences and Household Expectations on Recovery: Survey Evidence from Northern Uganda [PDF]
We analyse the role of mass violent conflict in influencing individual expectations. We hypothesise that individuals are likely to report negative expectations if they were exposed to conflict events in the past. We combine individual and household level
Carlos Bozzoli +2 more
core
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Punishment sensitivity predicts the impact of punishment on cognitive control [PDF]
, 2013 Cognitive control theories predict enhanced conflict adaptation after punishment. However, no such effect was found in previous work. In the present study, we demonstrate in a flanker task how behavioural adjustments following punishment signals are ...
Braem, Senne +2 more
core +2 more sources
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Kantian fractionalization predicts the conflict propensity of the international system [PDF]
, 2014 The study of complex social and political phenomena with the perspective and methods of network science has proven fruitful in a variety of areas, including applications in political science and more narrowly the field of international relations.
Cranmer, Skyler J. +2 more
core +3 more sources
FEBS Letters, EarlyView.Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas +3 more
wiley +1 more source
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source