Results 101 to 110 of about 5,429,572 (303)

The effect of role ambiguity and role conflict on job performance in the hotel industry: The mediating effect of job satisfaction

Tourism & Management Studies, 2021
Accommodation businesses are stressful workplaces due to their dynamic and demanding work environment. Role ambiguity and role conflict are major stress factors for hotel emplyees causing low levels of satisfaction, performance and high levels of ...
Engin Üngüren, Serdar Arslan
doaj  

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Climate change and the kidney [PDF]

, 2019
The worldwide increase in temperature has resulted in a marked increase in heat waves (heat extremes) that carries a markedly increased risk for morbidity and mortality.
Butler-Dawson, Jaime, Diaz, Henry F., Garcia, Gabriela, Hernando, Ana Andres, Johnson, Richard J., Lanaspa, Miguel A., Lemery, Jay, Newman, Lee S., Rodriguez-Iturbe, Bernardo, Roncal-Jimenez, Carlos A., Sato, Yuka, Sánchez-Lozada, Laura G., Tolan, Dean R.   +12 more
core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

The Interpretation of Experimental Observation Data for the Development of Mechanisms based Creep Damage Constitutive Equations for High Chromium Steel [PDF]

, 2015
It is very important to design a safe factor or estimating the remain lifetime for electric power plant components of steam pipes which mostly manufacture by high chromium steels and work at high temperature and low stress level.
Lu, Zhongyu, Xu, Qiang, Yang, Xin
core   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Ethnic Microaggressions, Traumatic Stress Symptoms, And Latino Depression: A Moderated Mediational Model [PDF]

, 2015
Although ethnic microaggressions have received increased empirical attention in recent years, there remains a paucity of research regarding how these subtle covert forms of discrimination contribute to Latino mental health. The present study examined the
Taknint, Joelle T., Torres, Lucas
core   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Leading from afar, losing from within: how and when laissez-faire leadership fuels quiet quitting behaviours of employees

Cogent Business & Management
This study investigates the influence of laissez-faire leadership on employee quiet quitting behaviours. Drawing on the Job Demands–Resources theory and the Stressor-Detachment model, it examines how laissez-faire leadership affects quiet quitting ...
Erasmus Keli Swanzy, Mercy DeSouza, Esther Julia Korkor Attiogbe, Rejoice Esi Asante   +3 more
doaj   +1 more source

Conservative Stress Testing: The Role of Regular Verification [PDF]

This paper focuses on how to calibrate models used to stress test the most important risks in the banking system. Based on the results of a verification of the Czech National Bank’s stress testing methodology, the paper argues that stress tests should be
Adam Gersl, Jakub Seidler
core   +1 more source