Results 111 to 120 of about 2,413,680 (306)

The Role of Orexin in Stress

, 2010
Orexins (hypocretins) are novel neuropeptides released by some neurons identified in lateral hypothalamus. They are involved in the regulation of energy metabolism, neuroendocrine, sleep and waking.
Han Jin, Sui Nan, Wang Hui-Ying, Wei Chu-Guang, Li Yong-Hui   +4 more
core  

Role Conflict, Role Ambiguity, and Turnover Intention: The Mediating Effect of Work Stress on Female Employees [PDF]

SHS Web of Conferences
This research explores the determinants of turnover intention among female employees within the Indonesian cigarette industry, with a specific focus on PT Karya Timur Prima.
Rizal Mohamad, Amin Muhammad Sirojuddin, Basalamah Muhammad Ridwan, Wahono Budi   +3 more
doaj   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

The effect of role ambiguity and role conflict on job performance in the hotel industry: The mediating effect of job satisfaction

Tourism & Management Studies, 2021
Accommodation businesses are stressful workplaces due to their dynamic and demanding work environment. Role ambiguity and role conflict are major stress factors for hotel emplyees causing low levels of satisfaction, performance and high levels of ...
Engin Üngüren, Serdar Arslan
doaj  

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

The two-component sensor kinase TcsC and its role in stress resistance of the human-pathogenic mold Aspergillus fumigatus. [PDF]

, 2012
Two-component signaling systems are widespread in bacteria, but also found in fungi. In this study, we have characterized TcsC, the only Group III two-component sensor kinase of Aspergillus fumigatus. TcsC is required for growth under hyperosmotic stress,
Ilse D. Jacobsen (149635), Beck, Julia, Marzena Broniszewska (160482), Jacobsen, Ilse D., Julia Beck, Beck Julia, Ebel, Frank, Jürgen Heesemann, Allison McCormick, Jacobsen Ilse D., Broniszewska Marzena, Heesemann Jürgen, Ilse D Jacobsen, Broniszewska, Marzena, Frank Ebel (160490), Julia Beck (160485), McCormick Allison, Allison McCormick (160475), Ebel Frank, Frank Ebel, Jürgen Heesemann (4231), Heesemann, Jürgen, Marzena Broniszewska, McCormick, Allison   +23 more
core   +1 more source

α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates

FEBS Letters, EarlyView.
Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino, Giuliana Fusco, Alfonso De Simone   +2 more
wiley   +1 more source

Oxidative stress in genetic mouse models of Parkinson's disease [PDF]

, 2012
There is extensive evidence in Parkinson’s disease of a link between oxidative stress and some of the monogenically inherited Parkinson’s disease-associated genes.
Bentea, Eduard, Michotte, Yvette, Varcin, Mustafa, Sarre, Sophie   +3 more
core   +1 more source

Leading from afar, losing from within: how and when laissez-faire leadership fuels quiet quitting behaviours of employees

Cogent Business & Management
This study investigates the influence of laissez-faire leadership on employee quiet quitting behaviours. Drawing on the Job Demands–Resources theory and the Stressor-Detachment model, it examines how laissez-faire leadership affects quiet quitting ...
Erasmus Keli Swanzy, Mercy DeSouza, Esther Julia Korkor Attiogbe, Rejoice Esi Asante   +3 more
doaj   +1 more source