Results 101 to 110 of about 2,413,680 (306)

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

The Role of Trauma-Specific Irrational Beliefs and Sociodemographic Risk Factors in Posttraumatic Stress Responses [PDF]

, 2013
Posttraumatic stress responses have been linked to a range of social-cognitive and sociodemographic factors. Rational Emotive Behaviour Therapy suggests that responding to a traumatic life event with a set of irrational beliefs should play a crucial role
Shevlin, Mark, Adamson, Gary, Hyland, Philip, Boduszek, Daniel   +3 more
core   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

The pneumococcal response to oxidative stress includes a role for Rgg. [PDF]

, 2009
Streptococcus pneumoniae resides in the oxygen-rich environment of the upper respiratory tract, and therefore the ability to survive in the presence of oxygen is an important aspect of its in vivo survival. To investigate how S.
Terra, VS, P. W. Andrew, Hasan Yesilkaya (345723), Hinds, Jason, Vanessa S. Terra (3610202), M. E. Bortoni, Andrew, PW, V. S. Terra, Yesilkaya, H, Bortoni, Magda E, Andrew, Peter W, Bortoni, ME, Hinds, J, Peter W. Andrew (153608), Yesilkaya, Hasan, H. Yesilkaya, J. Hinds, Terra, Vanessa S, J. Hinds (7607714)   +18 more
core   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

The role of sigma factor RpoH1 in the pH stress response of Sinorhizobium meliloti

, 2010
de Lucena DK, Pühler A, Weidner S. The role of sigma factor RpoH1 in the pH stress response of Sinorhizobium meliloti. BMC Microbiology. 2010;10(1): 256.Background: Environmental pH stress constitutes a limiting factor for S.
Argandoña, Montserrat, Iglesias Guerra, Fernando, Jebbar Mohamed, Reina-Bueno Mercedes, Argandoña Montserrat, Mohamed Jebbar, Mercedes Reina-Bueno, Joaquín J Nieto, Reina Bueno, Mercedes, Argandoña Bertrán, Montserrat, Rodríguez-Moya, Javier, Vargas Macías, Carmen, Iglesias-Guerra Fernando, Jebbar, Mohamed, Nieto Joaquín J, Javier Rodríguez-Moya, Fernando Iglesias-Guerra, Vargas Carmen, de Lucena, Daniella Karine, Reina-Bueno, Mercedes, Rodríguez de Moya Vera, Javier, Pühler, Alfred ; https://orcid.org/, Iglesias-Guerra, Fernando, Weidner, Stefan, Nieto Gutiérrez, Joaquín José, Rodríguez-Moya Javier, Nieto, Joaquín J, Vargas, Carmen, Carmen Vargas, Montserrat Argandoña   +29 more
core   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Dealing with employees’ frustration in time saves your company from workplace bullying: The mediating roles of frustration and a hostile climate in the relationship between role stress and exposure to workplace bullying

Cogent Business & Management
The development of workplace bullying, which involves negative behaviors occurring regularly and over a period of time, is explained by the work environment hypothesis, namely, that it is due to organizational factors, such as leadership practices and ...
Piotr Stapinski, Malgorzata Gamian-Wilk
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source