MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Conservative Stress Testing: The Role of Regular Verification
This paper focuses on how to calibrate models used to stress test the most important risks in the banking system. Based on the results of a verification of the Czech National Bank’s stress testing methodology, the paper argues that stress tests should be
Adam Gersl, Jakub Seidler
core
Perceived Professional Identity and Role Stress among Midwifery Students in South Central Mindanao: A Cross-sectional Study. [PDF]
Acta Med PhilippLiba ES, Falguera CC, Atendido MRA.
europepmc +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Being a woman in sports arenas: the relationship between gender role stress and sports motivation. [PDF]
Front Public HealthYalcin I +5 more
europepmc +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Individual differences and occupational stress perceived: a Croatian survey [PDF]
Apart from elaborating the concept of occupational stress (through it’s definition, sources, consequences, ways of dealing with it, and it’s relationship with individual differences), the research had two objectives: (1) to measure occupational stress ...
Nina Pološki Vokić, Ana Bogdanić
core
A study on the relationship between role stress and job burnout among community mental health workers: using psychological capital as a mediating variable. [PDF]
BMC PsycholLu HK, Chu HC, Chen YC.
europepmc +1 more source
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
The relationship between role stress and compassion fatigue of medical workers: the mediating role of emotional labor and the moderating role of positive psychological capital. [PDF]
BMC PsycholHe T, Hou Y.
europepmc +1 more source