Cost-effectiveness of romosozumab for the treatment of postmenopausal women with osteoporosis at high risk of fracture in Belgium [PDF]
Summary: This study evaluated the cost-effectiveness of sequential treatment with romosozumab-to-alendronate compared to alendronate monotherapy and teriparatide-to-alendronate, in postmenopausal osteoporotic women from a Belgian healthcare perspective ...
Aldvén, Martina +5 more
core +1 more source
Comparative Analysis of Romosozumab Versus Vertebroplasty With Denosumab: Efficacy, Safety, and Secondary Bone Mineral Density Outcomes [PDF]
NeurospineObjective This study aimed to compare the efficacy and safety of romosozumab, a bone anabolic agent, versus vertebroplasty, a conventional surgical intervention, in treating osteoporotic vertebral compression fractures (OVCFs).
Hyun Woong Mun +5 more
doaj +1 more source
Current and emerging osteoporosis pharmacotherapy for women: state of the art therapies for preventing bone loss. [PDF]
, 2019 INTRODUCTION: Pharmacological options to address the imbalance between bone resorption and accrual in osteoporosis include anti-resorptive and osteoanabolic agents.
Afroditi Papachristou +15 more
core +1 more source
Impact of osteoporosis and osteoporosis medications on fracture healing: a narrative review [PDF]
Summary: Antiresorptive medications do not negatively affect fracture healing in humans. Teriparatide may decrease time to fracture healing. Romosozumab has not shown a beneficial effect on human fracture healing.
Akesson, K. E. +16 more
core +5 more sources
The potential effect of romosozumab on perioperative management for instrumentation surgery
JOR SpineBackground Age‐related changes in bone health increase the risk for complications in elderly patients undergoing orthopedic surgery. Osteoporosis is a key therapeutic target that needs to be addressed to ensure successful instrumentation surgery.
Koji Ishikawa +11 more
doaj +1 more source
Asia-Pacific consensus on long-term and sequential therapy for osteoporosis. [PDF]
OBJECTIVES: This study aimed to present the Asia-Pacific consensus on long-term and sequential therapy for osteoporosis, offering evidence-based recommendations for the effective management of this chronic condition.
Ang, SB +46 more
core +1 more source
Comparing Romosozumab and Alendronate in the Treatment of Osteoporosis in Postmenopausal Women [PDF]
, 2020 The purpose of this literature review is to determine if there is a statistical difference in the safety and efficacy between romosozumab, the prototypical drug in the new drug class sclerostin inhibitors, versus alendronate, the prototypical ...
Johnshoy, Taylor
core +2 more sources
Incident Vertebral Fractures During Romosozumab Treatment in a Patient With a Pathogenic LRP5 Variant [PDF]
A defect in the canonical Wnt-β-catenin pathway may lead to reduced bone strength and increased fracture risk. Sclerostin is a key inhibitor of this pathway by binding to low-density lipoprotein (LDL) receptor-related protein (LRP)-5/6, thereby reducing ...
Muradin, Galied +3 more
core +2 more sources
Inclusion Health: Addressing the Causes of the Causes [PDF]
, 2017 The social gradient in health describes a graded association between an individual's position on the social hierarchy and health: the lower the socioeconomic position of an individual, the worse their health.
Aldridge +8 more
core +2 more sources