Results 21 to 30 of about 193,824 (285)

Generation of ROR gamma t(+) Antigen-Specific T Regulatory 17 Cells from Foxp3(+) Precursors in Autoimmunity [PDF]

, 2017
Th17 cells are potent mediators in autoimmune diseases, and RORgt is required for their development. Recent studies have shown that ROR gamma t(+) Treg cells in the gut regulate intestinal inflammation by inhibiting effector T cell function.
Chang, Seon Hee, Chen, Xiang, Chung, Yeonseok, Dong, Chen, Ichiyama, Kenji, Jin, Wei, Kim, Byung-Seok, Lee, Young-hee, Lu, Huiping, Mistry, Nipun A., Nurieva, Roza, Tanaka, Kentaro, Yang, Xuexian, Zhang, Li, Zhang, Yi-Bing   +14 more
core   +2 more sources

Development and testing of a polygenic risk score for breast cancer aggressiveness

npj Precision Oncology, 2023
Aggressive breast cancers portend a poor prognosis, but current polygenic risk scores (PRSs) for breast cancer do not reliably predict aggressive cancers. Aggressiveness can be effectively recapitulated using tumor gene expression profiling.
Yiwey Shieh, Jacquelyn Roger, Christina Yau, Denise M. Wolf, Gillian L. Hirst, Lamorna Brown Swigart, Scott Huntsman, Donglei Hu, Jovia L. Nierenberg, Pooja Middha, Rachel S. Heise, Yushu Shi, Linda Kachuri, Qianqian Zhu, Song Yao, Christine B. Ambrosone, Marilyn L. Kwan, Bette J. Caan, John S. Witte, Lawrence H. Kushi, Laura van ‘T Veer, Laura J. Esserman, Elad Ziv   +22 more
doaj   +1 more source

CD4+RORγt++ and Tregs in a Mouse Model of Diet‐Induced Nonalcoholic Steatohepatitis [PDF]

Mediators of Inflammation, 2015
Background and Aims. Inflammatory mediators that cross‐talk in different metabolically active organs are thought to play a crucial role in the pathogenesis of Nonalcoholic Steatohepatitis (NASH). This study was aimed at investigating the CD4+RORγt+ T‐helper cells and their counterpart, the CD4+CD25+FOXP3+ regulatory T cells in the liver, subcutaneous ...
Luisa Vonghia, Nathalie Ruyssers, Dorien Schrijvers, Paul Pelckmans, Peter Michielsen, Luc De Clerck, Albert Ramon, Emilio Jirillo, Didier Ebo, Benedicte De Winter, Chris Bridts, Sven Francque   +11 more
openaire   +3 more sources

ROR-γ drives androgen receptor expression and represents a therapeutic target in castration-resistant prostate cancer. [PDF]

, 2016
The androgen receptor (AR) is overexpressed and hyperactivated in human castration-resistant prostate cancer (CRPC). However, the determinants of AR overexpression in CRPC are poorly defined.
Borowsky, Alexander D, Cai, Demin, Chen, Hong-Wu, Duan, Zhijian, Evans, Christopher P, Evans, Ronald M, Gao, Allen C, Kung, Hsing-Jien, Lam, Kit S, Louie, Maggie C, Wang, Junjian, Xiang, Qiuping, Xu, Jianzhen, Xu, Yong, Xue, Xiaoqian, Yang, Joy C, Zhang, Yan, Zou, June X   +17 more
core   +2 more sources

The effects of run-of-river hydroelectric power schemes on invertebrate community composition in temperate streams and rivers. [PDF]

PLoS ONE, 2017
Run-of-river (ROR) hydroelectric power (HEP) schemes are often presumed to be less ecologically damaging than large-scale storage HEP schemes. However, there is currently limited scientific evidence on their ecological impact.
Gary S Bilotta, Niall G Burnside, Matthew D Turley, Jeremy C Gray, Harriet G Orr   +4 more
doaj   +1 more source

A Framework for Bioacoustic Vocalization Analysis Using Hidden Markov Models [PDF]

, 2009
Using Hidden Markov Models (HMMs) as a recognition framework for automatic classification of animal vocalizations has a number of benefits, including the ability to handle duration variability through nonlinear time alignment, the ability to incorporate ...
Clemins, Patrick J., Darre, Michael, Glaeser, Sharon Stuart, Johnson, Michael T, Osiejuk, Tomasz S., Out-Nyarko, Ebenezer, Ren, Yao   +6 more
core   +4 more sources

Archetype Model-Driven Development Framework for EHR Web System [PDF]

Healthcare Informatics Research, 2013
ObjectivesThis article describes the Web application framework for Electronic Health Records (EHRs) we have developed to reduce construction costs for EHR sytems.MethodsThe openEHR project has developed clinical model driven architecture for future-proof
Shinji Kobayashi, Eizen Kimura, Ken Ishihara   +2 more
doaj   +1 more source

FRI0153 Role of ror gamma t inhibition in the il-23 minicircle model and spa patient tissue cultures [PDF]

Annals of the Rheumatic Diseases, 2018
Background Retinoic acid receptor related Orphan Receptor gamma t (RORγt) is a nuclear hormone receptor expressed in a subset of pathogenic T cells and innate lymphoid cells. RORγt regulates the transcription of key pro inflammatory cytokines such as IL-17 and IL-22 in response to multiple activation signals including cytokines and T cell receptor ...
K. Hoyt, J. Galdamez, M. Panzenbeck, D. Souza, E. Glynn, J. Pelletier, M. Lewis, G. Nabozny, E. Purdue, L.A. Mandl, J. Wahle   +10 more
openaire   +1 more source

Benchmarking and Regulation of Electricity Transmission and Distribution Utilities: Lessons from International Experience [PDF]

, 2004
Since the early 1980's, many countries have implemented electricity sector reform, many of which have bundled generation, transmission, distribution and supply activities, and have introduced competition in generation and supply. An increasing number
Jamasb, Tooraj, Pollitt, Michael G.
core   +1 more source

OSNA Total Tumor Load for the Prediction of Axillary Involvement in Breast Cancer Patients: Should We use Different Thresholds According to the Intrinsic Molecular Subtype? MOTTO Study

Clinical Pathology, 2023
Aims: To assess the impact of the molecular subtype (MS) on the total number of CK19 mRNA copies in all positive SLN (TTL) threshold, to predict non-SLN affectation, and to compare 5 years progression-free survival (PFS) according to the risk of ...
L Bernet, D Hardisson, M Rodrigo, A Córdoba, M Sancho, V Peg, I Ruiz, F Godey, JI Sánchez-Méndez, A Prat   +9 more
doaj   +1 more source