Results 71 to 80 of about 890,859 (295)

Effects of the anti-oxidant PDTC in combination with a single bout of treadmill running on murine skeletal muscle

Redox Report, 2020
Objectives: Skeletal muscle adaptation to physical activity is dependent on various factors. Important signaling mediators are reactive oxygen species (ROS).
Angelika Schmitt, Anne-Lena Brändle, Pascal Herzog, Franziska Röchner, Annunziata Fragasso, Barbara Munz   +5 more
doaj   +1 more source

Nanoparticles as Tools to Target Redox Homeostasis in Cancer Cells

Antioxidants, 2020
Reactive oxygen species (ROS) constitute a homeostatic rheostat that modulates signal transduction pathways controlling cell turnover. Most oncogenic pathways activated in cancer cells drive a sustained increase in ROS production, and cancer cells are ...
Francesco Ciccarese, Vittoria Raimondi, Evgeniya Sharova, Micol Silic-Benussi, Vincenzo Ciminale   +4 more
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

3D perception with ROS and PCL

, 2014
18 FolienNowadays, first experiences in 3D perception can be easily obtained using ROS and PCL. ROS provides a communication layer and a user-friendly 3D visualization toolkit.
Arbeiter, Georg
core   +2 more sources

The rice Aux/IAA transcription factor gene OsIAA18 enhances salt and osmotic tolerance in Arabidopsis

Biologia Plantarum, 2020
In plants, auxin/indoleacetic acid (Aux/IAA) proteins are transcriptional regulators, which regulate developmental process and responses to phytohormones and stress treatments.
G. LI, Y.X. YE, X.Q. REN, M.Y. QI, H.Y. ZHAO, Q. ZHOU, X.H. CHEN, J. WANG, C.Y. YUAN, F.B. WANG   +9 more
doaj   +1 more source

The multifaceted roles of lysosomes in cancer

Molecular Oncology, EarlyView.
Lysosomes support cancer cell adaptation by integrating macromolecule degradation and nutrient recycling with nutrient sensing, inter‐organelle communication and immune regulation. These interconnected functions can promote tumour growth, stress tolerance and therapy resistance, while also creating context‐dependent vulnerabilities that may be ...
Jia Li, Kevin M. Ryan
wiley   +1 more source

Overcoming platinum resistance by the disulfiram metabolite CuET in novel preclinical models of human carcinomas

Molecular Oncology, EarlyView.
Cisplatin‐resistant cancer cells survive DNA‐damaging platinum‐based treatment yet remain sensitive to CuET‐induced proteotoxic stress. The distinct mechanism of action allows CuET to overcome and eliminate cisplatin‐resistant tumour cells, unless highly expressed metallothioneins (MTs) interfere with CuET, thereby highlighting MT levels as candidate ...
Stefanos Arampatzis, Tereza Buchtová, Jirina Bartkova, Marie Lund Bay, Christoffer Lynge Halvorsen, Zuzana Machacova, Zdenek Skrott, Martin Mistrik, Ekaterina Dulina, Miguel Andujar‐Sanchez, Estrid Høgdall, Tine Henrichsen Schnack, Claus Høgdall, Berit Jul Mosgaard, Marie Boennelycke, Jacob Brink Laursen, Allan Jensen, Susanne K. Kjær, Tuula Kallunki, Robert Strauss, Jiri Bartek   +20 more
wiley   +1 more source

ROS-Responsive Selenopolypeptide Micelles: Preparation, Characterization, and Controlled Drug Release

, 2022
Sulfur-containing polypeptides, capable of reactive oxygen species (ROS)-responsive structural change, are one of the most important building blocks for the construction of polypeptide-based drug delivery systems.
Lichen Yin (1315224), Chenglong Ge (2626258), Guangqi Wu (10766218), Huan Ye (1793494), Hua Lu (240206), Junliang Zhu (12529942)   +5 more
core   +1 more source

3D perception with ROS and PCL

, 2022
9 FolienNowadays, first experiences in 3D perception can be easily obtained using ROS and PCL. ROS provides a communication layer and a user-friendly 3D visualization toolkit.
Hampp, Joshua
core   +1 more source