Results 71 to 80 of about 746,641 (302)

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Feasibility and acceptability of a peer-led mindful self-compassion program for adults with eating disorder symptoms

BMC Psychiatry
Background The implementation of peer-led programs provided by individuals with lived experience of mental disorders has been increasingly acknowledged as a key component in improving the quality of mental health services.
Maren Kjeldstad, Ingunn Mundal, Irene Kingswick, Håvard Horndalen Tveit, Mariela L. Lara-Cabrera   +4 more
doaj   +1 more source

Effects of the anti-oxidant PDTC in combination with a single bout of treadmill running on murine skeletal muscle

Redox Report, 2020
Objectives: Skeletal muscle adaptation to physical activity is dependent on various factors. Important signaling mediators are reactive oxygen species (ROS).
Angelika Schmitt, Anne-Lena Brändle, Pascal Herzog, Franziska Röchner, Annunziata Fragasso, Barbara Munz   +5 more
doaj   +1 more source

Nanoparticles as Tools to Target Redox Homeostasis in Cancer Cells

Antioxidants, 2020
Reactive oxygen species (ROS) constitute a homeostatic rheostat that modulates signal transduction pathways controlling cell turnover. Most oncogenic pathways activated in cancer cells drive a sustained increase in ROS production, and cancer cells are ...
Francesco Ciccarese, Vittoria Raimondi, Evgeniya Sharova, Micol Silic-Benussi, Vincenzo Ciminale   +4 more
doaj   +1 more source

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

The rice Aux/IAA transcription factor gene OsIAA18 enhances salt and osmotic tolerance in Arabidopsis

Biologia Plantarum, 2020
In plants, auxin/indoleacetic acid (Aux/IAA) proteins are transcriptional regulators, which regulate developmental process and responses to phytohormones and stress treatments.
G. LI, Y.X. YE, X.Q. REN, M.Y. QI, H.Y. ZHAO, Q. ZHOU, X.H. CHEN, J. WANG, C.Y. YUAN, F.B. WANG   +9 more
doaj   +1 more source

Ros bandt sound sculptor

, 2007
Ros Bandt is a composer-performer and sound artist, who is passionate about combining ancient and modern sonic practices. her sound research has included buildinga medieval Ptyhagorean recorder and she directs the Australian sound design project online ...
Mandelberg, John, Bandt, Ros, Sherman, Nikolai   +2 more
core  

3D perception with ROS and PCL

, 2015
18 FolienNowadays, first experiences in 3D perception can be easily obtained using ROS and PCL. ROS provides a communication layer and a user-friendly 3D visualization toolkit.
Hampp, Joshua
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source