Results 51 to 60 of about 570,104 (268)

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Therapeutic Effects of Cold-Pressed Perilla Oil Mainly Consisting of Linolenic acid, Oleic Acid and Linoleic Acid on UV-Induced Photoaging in NHDF Cells and SKH-1 Hairless Mice

Molecules, 2020
Positive physiological benefits of several plant oils on the UV-induced photoaging have been reported in some cell lines and model mice, but perilla oil collected from the seeds of Perilla frutescens L. has not been investigated in this context. To study
Hyeon Jun Choi, Bo Ram Song, Ji Eun Kim, Su Ji Bae, Yun Ju Choi, Su Jin Lee, Jeong Eun Gong, Hee Seob Lee, Chung Yeoul Lee, Bae-Hwan Kim, Dae Youn Hwang   +10 more
doaj   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

A scoping review of instruments used to assess disordered eating in children and adolescents with higher weight

Journal of Eating Disorders
Background Disordered eating behaviors are prevalent among children and adolescents with overweight and obesity but are frequently overlooked or underrecognized.
Deborah Lynn Reas, Sunniva Nordang, Yngvild Sørebø Danielsen, Hanna Flækøy Skjåkødegård, Sunniva Beeder Mollandsøy, Sara Shah   +5 more
doaj   +1 more source

In Vitro and In Vivo Nutraceutical Characterization of Two Chickpea Accessions: Differential Effects on Hepatic Lipid Over-Accumulation

Antioxidants, 2020
Dietary habits are crucially important to prevent the development of lifestyle-associated diseases. Diets supplemented with chickpeas have numerous benefits and are known to improve body fat composition.
Mariangela Centrone, Patrizia Gena, Marianna Ranieri, Annarita Di Mise, Mariagrazia D’Agostino, Maria Mastrodonato, Maria Venneri, Davide De Angelis, Stefano Pavan, Antonella Pasqualone, Carmine Summo, Valentina Fanelli, Giovanna Valenti, Giuseppe Calamita, Grazia Tamma   +14 more
doaj   +1 more source

A yeast model of 5‐oxoproline accumulation reveals a general toleration to 5‐oxoproline

FEBS Open Bio, EarlyView.
Using a yeast model, we show that even high accumulation of 5‐oxoproline causes only mild cellular stress and does not trigger oxidative stress. Instead, cells adapt by activating efflux pumps and diverse protective pathways, suggesting that previously proposed harmful effects of 5‐oxoproline may arise from indirect metabolic imbalances rather than the
Pratiksha Dubey, Vaishnavi Sanjayan, Praveen Singh, Shantanu Sengupta, Anand Kumar Bachhawat   +4 more
wiley   +1 more source

Feasibility and acceptability of a peer-led mindful self-compassion program for adults with eating disorder symptoms

BMC Psychiatry
Background The implementation of peer-led programs provided by individuals with lived experience of mental disorders has been increasingly acknowledged as a key component in improving the quality of mental health services.
Maren Kjeldstad, Ingunn Mundal, Irene Kingswick, Håvard Horndalen Tveit, Mariela L. Lara-Cabrera   +4 more
doaj   +1 more source

Effects of the anti-oxidant PDTC in combination with a single bout of treadmill running on murine skeletal muscle

Redox Report, 2020
Objectives: Skeletal muscle adaptation to physical activity is dependent on various factors. Important signaling mediators are reactive oxygen species (ROS).
Angelika Schmitt, Anne-Lena Brändle, Pascal Herzog, Franziska Röchner, Annunziata Fragasso, Barbara Munz   +5 more
doaj   +1 more source

Nanoparticles as Tools to Target Redox Homeostasis in Cancer Cells

Antioxidants, 2020
Reactive oxygen species (ROS) constitute a homeostatic rheostat that modulates signal transduction pathways controlling cell turnover. Most oncogenic pathways activated in cancer cells drive a sustained increase in ROS production, and cancer cells are ...
Francesco Ciccarese, Vittoria Raimondi, Evgeniya Sharova, Micol Silic-Benussi, Vincenzo Ciminale   +4 more
doaj   +1 more source