Results 41 to 50 of about 570,104 (268)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Fire Risk Model for Fires in Ro-Ro Ship Ro-Ro Spaces

Journal of Risk Analysis and Crisis Response
In recent years, fire accidents on Ro-Ro ships have led to numerous fatalities and significant economic losses. The response of the crew and the ship's protection systems are crucial in managing these incidents and mitigating their consequences. To assess fire safety improvements, this study has focused on developing and quantifying a risk model that ...
Dahlbom, Sixten, Andersson, Stina, De Carvalho, Eric, Lewandowski, Leon, Evegren, Franz   +4 more
openaire   +3 more sources

Modification of the EEDI for Ro-ro Passenger Ships [PDF]

SNAME Maritime Convention and 5th World Maritime Technology Conference, 2015
In the 3rd IMO GHG study the new data on the ships emissions indicate a clear need for improvements in ship energy efficiency in order to preserve the environment. Although the majority of the pollution originates from the international shipping, the environmental impact of the short-sea shipping, primarily from ro-ro passenger ships, should not be ...
Šestan, Ante, Ančić, Ivica, Vladimir, Nikola   +2 more
openaire   +2 more sources

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

AN ANALYSIS OF THE ITALIAN RO-RO AND RO-PAX NETWORK IN THE YEARS 2008-2015 [PDF]

Transport Problems, 2018
In this paper, the development of Motorways of the Sea (MoS) services offered at Italian ports from 2008 to 2015 is analyzed. In particular, a detailed research on MoS routes calling at Italian ports in the year 2015 is carried out; within MoS routes: ro-pax and only cargo ro-ro services are identified.
Marino LUPI, Alessandro FARINA, Antonio PRATELLI, Letizia BELLUCCI   +3 more
openaire   +3 more sources

Isolation of a Psychrotolerant and UV-C-Resistant Bacterium from Elephant Island, Antarctica with a Highly Thermoactive and Thermostable Catalase

Microorganisms, 2020
Microorganisms present in Antarctica have to deal not only with cold temperatures but also with other environmental conditions, such as high UV radiation, that trigger the generation of reactive oxygen species.
María T. Monsalves, Gabriela P. Ollivet-Besson, Maximiliano J. Amenabar, Jenny M. Blamey   +3 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source