DNA demethylation by ROS1a in rice vegetative cells promotes methylation in sperm. [PDF]
, 2019 Epigenetic reprogramming is required for proper regulation of gene expression in eukaryotic organisms. In Arabidopsis, active DNA demethylation is crucial for seed viability, pollen function, and successful reproduction. The DEMETER (DME) DNA glycosylase
Fischer, Robert L +6 more
core +2 more sources
Expression and rearrangement of the ROS1 gene in human glioblastoma cells [PDF]
, 1987 The human ROS1 gene, which possibly encodes a growth factor receptor, was found to be expressed in human tumor cell lines. In a survey of 45 different human cell lines, we found ROS1 to be expressed in glioblastoma-derived cell lines at high levels and ...
Birchmeier, C. +2 more
core +2 more sources
Small cell transformation of ROS1 fusion-positive lung cancer resistant to ROS1 inhibition [PDF]
npj Precision Oncology, 2020 AbstractHistologic transformation from non-small cell to small cell lung cancer has been reported as a resistance mechanism to targeted therapy in EGFR-mutant and ALK fusion-positive lung cancers. Whether small cell transformation occurs in other oncogene-driven lung cancers remains unknown.
Jessica J. Lin +20 more
openaire +2 more sources
The Frequency and Clinical Implication of ROS1 and RET Rearrangements in Resected Stage IIIA-N2 Non-Small Cell Lung Cancer Patients. [PDF]
PLoS ONE, 2015 To evaluate the frequency and clinicopathological features of ROS1 and RET rearrangements in N2 node positive stage IIIA (IIIA-N2) non-small cell lung cancer (NSCLC) patients, we retrospectively screened 204 cases with a tissue microarray (TMA) panel by ...
Sha Fu +8 more
doaj +1 more source
Discovery of oncogenic ROS1 missense mutations with sensitivity to tyrosine kinase inhibitors
EMBO Molecular Medicine, 2023 ROS1 is the largest receptor tyrosine kinase in the human genome. Rearrangements of the ROS1 gene result in oncogenic ROS1 kinase fusion proteins that are currently the only validated biomarkers for targeted therapy with ROS1 TKIs in patients.
Sudarshan R Iyer +9 more
doaj +1 more source
ROS1-Rearranged Lung Adenocarcinoma: From Molecular Genetics to Target Therapy
Onco, 2023 Non-small-cell lung cancer (NSCLC) is a heterogeneous group of diseases accounting for 80–85% of lung cancers. A molecular subset of NSCLC (1–2.5%) harboring molecular rearrangements of the tyrosine kinase gene ROS1 is defined as ROS1-positive and is ...
Ugo Testa +2 more
doaj +1 more source
Intrinsic resistance to ROS1 inhibition in a patient with CD74‐ROS1 mediated by AXL overexpression
Thoracic Cancer, 2023 Background The vast majority of patients with ROS1 positive non‐small cell lung cancer (NSCLC) derive clinical benefit from currently approved ROS1 therapies, including crizotinib and entrectinib. However, a small proportion of patients treated with ROS1
Tara L. Peters +5 more
doaj +1 more source
PD-L1 testing for lung cancer in the UK: recognizing the challenges for implementation. [PDF]
, 2016 A new approach to the management of non-small-cell lung cancer (NSCLC) has recently emerged that works by manipulating the immune checkpoint controlled by programmed death receptor 1 (PD-1) and its ligand programmed death ligand 1 (PD-L1).
Booton, R +11 more
core +2 more sources
Detection of ROS1 gene rearrangement in lung adenocarcinoma: comparison of IHC, FISH and real-time RT-PCR. [PDF]
PLoS ONE, 2015 AIMS:To compare fluorescence in situ hybridization (FISH), immunohistochemistry (IHC) and quantitative real-time reverse transcription-PCR (qRT-PCR) assays for detection of ROS1 fusion in a large number of ROS1-positive lung adenocatcinoma (ADC) patients.
Ling Shan +6 more
doaj +1 more source
The catalytic core of DEMETER guides active DNA demethylation in Arabidopsis. [PDF]
, 2019 The Arabidopsis DEMETER (DME) DNA glycosylase demethylates the maternal genome in the central cell prior to fertilization and is essential for seed viability.
Aravind, L. +15 more
core +2 more sources