Results 81 to 90 of about 29,549 (204)

Immunohistochemical Detection ofROS1Fusion [PDF]

American Journal of Clinical Pathology, 2016
Patients whose tumors harbor ROS1 translocation may benefit from targeted therapy. Detection of ROS1 rearrangement can be done by three methods: immunohistochemistry, fluorescence in situ hybridization, and molecular assays. Immunohistochemistry would be a cost-effective means to screen for ROS1 translocation, which is uncommon.ROS1 immunostain was ...
Yuhua, Su, Theodore, Goncalves, Dora, Dias-Santagata, Mai P, Hoang   +3 more
openaire   +2 more sources

The environmentally responsive plant epigenome: insights from jasmonate signaling

New Phytologist, EarlyView.
Summary The environmental responsiveness of the plant epigenome is essential for spatiotemporally precise gene regulation, enabling plants to adapt to external cues. Elucidating the mechanisms underlying this responsiveness is therefore fundamental to deciphering the molecular logic of plant‐environment interactions.
Mark Zander, Emily Vesper
wiley   +1 more source

ROS1-fusion protein induces PD-L1 expression via MEK-ERK activation in non-small cell lung cancer

OncoImmunology, 2020
Introduction Despite some of the oncogenic driver mutations that have been associated with increased expression of programmed death-ligand 1 (PD-L1), the correlation between PD-L1 expression and ROS1 fusion in NSCLC cells, especially for those with ...
Zheng Liu, Kejia Zhao, Shiyou Wei, Chengwu Liu, Jiankang Zhou, Qiheng Gou, Xia Wu, Zhenyu Yang, Yanbo Yang, Yong Peng, Qing Cheng, Lunxu Liu   +11 more
doaj   +1 more source

Building a Driving Simulator as an Electric Vehicle Hardware Development Tool [PDF]

, 2012
Driving simulators have been used to support the development of new vehicle systems for many years. The rise of electric vehicles (EVs) as a means of reducing carbon emissions has lead to the emergence of a number of new design ...
Knowles, Michael, Kok, Dirk, Morris, Adrian   +2 more
core  

Linking Superoxide Production and Scavenging in Plant Development

Plant, Cell &Environment, EarlyView.
ABSTRACT Due to their strong oxidizing potential, rapid membrane permeability, and high reactivity, reactive oxygen species (ROS) play essential roles in plant development and stress responses. Superoxide (O2•‐) is a primary product of molecular oxygen reduction and a crucial source of hydrogen peroxide, representing a ROS species of substantial ...
Jan Řehák, Maryna Tsinyk, Petr Dvořák, Tomáš Takáč   +3 more
wiley   +1 more source

Epigenetic modifications regulate peg elongation and underground fruiting in peanut in response to environmental cues

The Plant Genome, Volume 19, Issue 1, March 2026.
Abstract Epigenetic regulation plays a central role in coordinating peanut (Arachis hypogaea L.) fruit pegging, a unique developmental process in which fertilized ovaries transition from aerial growth to subterranean pod formation. This review synthesizes current evidence demonstrating that dynamic interactions among DNA methylation, histone ...
Yohannes Gelaye, Huaiyong Luo
wiley   +1 more source

Multi-level engineering facilitates the production of phenylpropanoid compounds in tomato [PDF]

, 2015
Phenylpropanoids comprise an important class of plant secondary metabolites. A number of transcription factors have been used to upregulate-specific branches of phenylpropanoid metabolism, but by far the most effective has been the fruit-specific ...
A Adato, A Angel, A Bovy, A Nunes-Nesi, A Pandey, AR Ballester, AT Wierzbicki, B Hamberger, B Langmead, CH Shih, CJ Liu, DC Centeno, E Butelli, E Logemann, F Mehrtens, G Rallapalli, GS Maloney, I Bilal, I Ingrosso, J Luo, J Nielsen, JA Baur, JA Baur, JM Franco-Zorrilla, K Morohashi, KM Herrmann, LM Voll, MA Perera, MD Robinson, N Shimada, P Daran-Lapujade, P Geigenberger, P Misra, P Morandini, R Mikstacka, RC Gentleman, S Bordel, S Osorio, S Zhong, T Tohge, TA Rees, TTY Wang, U Hartmann, U Roessner, V Cardile, V Tzin, V Tzin, WS De Jong, Y Zhang, Y Zhang   +49 more
core   +1 more source

Rare Germline Variants in CDKN2A‐Negative Children and Adolescents With Cutaneous Melanoma

Pigment Cell &Melanoma Research, Volume 39, Issue 2, March 2026.
Individuals with childhood and adolescent melanoma carry inherited mutations in shelterin complex genes, pigmentation genes and MBD4, but have fewer MC1R R‐alleles than adults with melanoma. Created with BioRender.com. ABSTRACT Cutaneous melanoma is a complex disease influenced by both environmental and genetic factors. Inherited susceptibility plays a
Peter A. Johansson, Jane M. Palmer, Linh T. Bui‐Raborn, Mai Xu, Kristine M. Jones, Herbert Higson, Jia Liu, Kelly M. Brooks, Antonia L. Pritchard, Nicholas K. Hayward, Kevin M. Brown   +10 more
wiley   +1 more source

Novel biosensors reveal a shift in the redox paradigm from oxidative to reductive stress in heart disease [PDF]

, 2016
No abstract ...
Anagnostopoulou, Aikaterini, De Lucca Camargo, Livia, Montezano, Augusto, Touyz, Rhian   +3 more
core   +1 more source

A Patient‐Derived Organoid Biobank of Adamantinomatous Craniopharyngioma as a Platform for Drug Discovery

Advanced Science, Volume 13, Issue 7, 3 February 2026.
This study successfully establishes adamantinomatous craniopharyngioma (ACP) patient‐derived organoids (PDOs) that preserve the histopathological and genetic features of the original tumors. Through drug sensitivity assays and subsequent mechanistic analyses, the study demonstrates that Ceritinib exerts its inhibitory effects on ACP PDO growth by ...
Huarong Zhang, Chaohu Wang, Jun Fan, Zexin Chen, Haoying Yu, Yawen Bai, Tingcheng Zhang, Qianchao Zhu, Yiwen Feng, Peirong Niu, Jiaqian Chen, Liping Yang, Xueying Li, Lei Yu, Songtao Qi, Yi Liu   +15 more
wiley   +1 more source