Results 31 to 40 of about 12,098 (189)

“Evaluation of ROS1 expression and rearrangements in a large cohort of early-stage lung cancer”

Diagnostic Pathology, 2023
Background ROS1 fusion is an infrequent, but attractive target for therapy in patients with metastatic non- small-cell lung cancer. In studies on mainly late-stage disease, the prevalence of ROS1 fusions is about 1–3%.
Anne Pernille Harlem Dyrbekk, Abdirashid Ali Warsame, Pål Suhrke, Marianne Odnakk Ludahl, Joakim Oliu Moe, Inger Johanne Zwicky Eide, Marius Lund-Iversen, Odd Terje Brustugun   +7 more
doaj   +1 more source

Case Report: Adjuvant Crizotinib Therapy Exerted Favorable Survival Benefit in a Resectable Stage IIIA NSCLC Patient With Novel LDLR–ROS1 Fusion

Frontiers in Oncology, 2022
Novel adjuvant strategies are needed to optimize outcomes after complete surgical resection in patients with early-stage non-small-cell lung cancer (NSCLC).
An-guo Chen, Dong-sheng Chen, Dong-sheng Chen, Dong-sheng Chen, Si Li, Si Li, Si Li, Le-le Zhao, Le-le Zhao, Le-le Zhao, Ming-zhe Xiao, Ming-zhe Xiao, Ming-zhe Xiao   +12 more
doaj   +1 more source

Pan-tumor survey of ROS1 fusions detected by next-generation RNA and whole transcriptome sequencing

BMC Cancer, 2023
Background Two ROS1 tyrosine kinase inhibitors have been approved for ROS1 fusion positive (ROS1+) non-small cell lung cancer (NSCLC) tumors. We performed a pan-tumor analysis of the incidence of ROS1 fusions to assess if more ROS1+ patients who could ...
Misako Nagasaka, Shannon S. Zhang, Yasmine Baca, Joanne Xiu, Jorge Nieva, Ari Vanderwalde, Jeffrey J. Swensen, David Spetzler, Wolfgang Michael Korn, Luis E. Raez, Stephen V. Liu, Sai-Hong Ignatius Ou   +11 more
doaj   +1 more source

Multiple Brain Metastases in a Patient with ROS1 Fusion-Positive Lung Adenocarcinoma as a Disease Flare due to Crizotinib Cessation Caused by Disseminated Aseptic Inflammation from Crizotinib-Associated Renal Cysts: A Case Report

Case Reports in Oncology, 2022
Rapid tumor growth after cessation of molecularly targeted drugs, called “disease flare,” may occur and affect the prognosis of lung cancer. However, this phenomenon has never been reported in ROS proto-oncogene 1 (ROS1) fusion-positive lung ...
Yosuke Amano, Hidenori Kage, Goh Tanaka, Yusuke Sato, Mariko Tanaka, Takahide Nagase   +5 more
doaj   +1 more source

Symptomatic CNS Radiation Necrosis Requiring Neurosurgical Resection During Treatment with Lorlatinib in ALK-Rearranged NSCLC: A Report of Two Cases. [PDF]

, 2020
Central nervous system (CNS) metastasis carries a significant morbidity and mortality in anaplastic lymphoma kinase (ALK)-rearranged non-small cell lung cancer (NSCLC).
Al-Holou, Wajd, Armas, Octavio, Kubota, Takafumi, Nagasaka, Misako, Ou, Sai-Hong Ignatius, Raval, Kunil, Robinette, Natasha, Zhu, Viola W   +7 more
core   +1 more source

An infant inflammatory myofibroblastoma with TFG-ROS1 fusion: a case report. [PDF]

J Med Case Rep
Inflammatory myofibroblastic tumors are extremely rare in the neck of infants, and pathological diagnosis may be challenging. Kinase fusions play an important role in the biology of many inflammatory myofibroblastic tumors, becoming an effective diagnostic method.In this report, we present the case of an East Asian (Han Chinese) patient with rare ...
Jiang H, Jiang J, Feng B, Yang Y, Li Q, Lian B, Ding X, Pan Z, Huang M, Pan Z, Huang J.   +10 more
europepmc   +4 more sources

ROS1-fusion protein induces PD-L1 expression via MEK-ERK activation in non-small cell lung cancer

OncoImmunology, 2020
Introduction Despite some of the oncogenic driver mutations that have been associated with increased expression of programmed death-ligand 1 (PD-L1), the correlation between PD-L1 expression and ROS1 fusion in NSCLC cells, especially for those with ...
Zheng Liu, Kejia Zhao, Shiyou Wei, Chengwu Liu, Jiankang Zhou, Qiheng Gou, Xia Wu, Zhenyu Yang, Yanbo Yang, Yong Peng, Qing Cheng, Lunxu Liu   +11 more
doaj   +1 more source

DNA demethylation by ROS1a in rice vegetative cells promotes methylation in sperm. [PDF]

, 2019
Epigenetic reprogramming is required for proper regulation of gene expression in eukaryotic organisms. In Arabidopsis, active DNA demethylation is crucial for seed viability, pollen function, and successful reproduction. The DEMETER (DME) DNA glycosylase
Fischer, Robert L, Kim, M Yvonne, Kinoshita, Tetsu, Okamoto, Takashi, Ono, Akemi, Scholten, Stefan, Zilberman, Daniel   +6 more
core   +2 more sources

Targeted DNA demethylation of the Arabidopsis genome using the human TET1 catalytic domain. [PDF]

, 2018
DNA methylation is an important epigenetic modification involved in gene regulation and transposable element silencing. Changes in DNA methylation can be heritable and, thus, can lead to the formation of stable epialleles. A well-characterized example of
Gallego-Bartolomé, Javier, Gardiner, Jason, Ghoshal, Basudev, Jacobsen, Steven E, Kuo, Hsuan Yu, Liu, Wanlu, Papikian, Ashot, Segal, David J, Zhao, Jenny Miao-Chi   +8 more
core   +2 more sources

Cabozantinib Overcomes Crizotinib Resistance in ROS1 Fusion–Positive Cancer [PDF]

Clinical Cancer Research, 2015
Abstract Purpose: ROS1 rearrangement leads to constitutive ROS1 activation with potent transforming activity. In an ongoing phase I trial, the ALK tyrosine kinase inhibitor (TKI) crizotinib shows remarkable initial responses in patients with non–small cell lung cancer (NSCLC) harboring ROS1 fusions; however, cancers eventually develop
Ryohei, Katayama, Yuka, Kobayashi, Luc, Friboulet, Elizabeth L, Lockerman, Sumie, Koike, Alice T, Shaw, Jeffrey A, Engelman, Naoya, Fujita   +7 more
openaire   +2 more sources