Results 41 to 50 of about 12,098 (189)

Construction of pcDNA3.1-CD74-ROS1 Recombinant Plasmid and Effect of CD74-ROS1 Expression on Proliferation and Migration of Lung Cancer Cells

Zhongliu Fangzhi Yanjiu, 2018
Objective To construct the recombinant plasmid carrying CD74-ROS1 fusion gene, and explore its effect on migration ability of A549 cells. Methods CD74 and ROS1 genes were obtained through PCR. The CD74-ROS1 fusion gene was constructed by fusion PCR.
WU Yazhou, LI Jia, ZHANG Lei
doaj   +1 more source

Clonal and microclonal mutational heterogeneity in high hyperdiploid acute lymphoblastic leukemia. [PDF]

, 2016
High hyperdiploidy (HD), the most common cytogenetic subtype of B-cell acute lymphoblastic leukemia (B-ALL), is largely curable but significant treatment-related morbidity warrants investigating the biology and identifying novel drug targets.
de Smith, Adam J, Endicott, Alyson A, Francis, Stephen S, Hansen, Helen M, Metayer, Catherine, Ojha, Juhi, Sanders, Erica, Smirnov, Ivan, Termuhlen, Amanda M, Walsh, Kyle M, Wiemels, Joseph L   +10 more
core   +1 more source

Potential novel therapy targets in neuroendocrine carcinomas of the breast [PDF]

, 2018
Neuroendocrine carcinoma (NEC) of the breast is a rare, special type of breast cancer, reportedly constituting 2% to 5% of all breast cancers. Although breast NEC does not have a specific targeted therapy, several new targeted therapies based on specific
Contreras, Elma, Florento, Elena, Gatalica, Zoran, Palazzo, Juan, Sanati, Souzan, Swensen, Jeffrey, Vranic, Semir, Xiu, Joanne   +7 more
core   +2 more sources

Prevalence of ROS1 fusion in Chinese patients with non‐small cell lung cancer

Thoracic Cancer, 2019
Background The study was conducted to investigate the clinicopathological features and prevalence of ROS1 gene fusion in Chinese patients with non‐small cell lung cancer (NSCLC).
Qing Zhang, Chunyan Wu, Wei Ding, Zhihong Zhang, Xueshan Qiu, Dianbin Mu, Haiqing Zhang, Yanfeng Xi, Jianhua Zhou, Liheng Ma, Shijun Fu, Min Gao, Bo Wang, Juan Deng, Dongmei Lin, Jie Zhang   +15 more
doaj   +1 more source

The DNA Repair Protein XRCC1 Functions in the Plant DNA Demethylation Pathway by Stimulating Cytosine Methylation (5-meC) Excision, Gap Tailoring, and DNA Ligation [PDF]

, 2013
Background: Active DNA demethylation in plants is initiated by 5-meC DNA glycosylases of the ROS1/DME family and continued through a base excision repair pathway.
Córdoba-Cañero, Dolores, Martínez-Macías, M.I., Rodríguez Ariza, Rafael, Roldán-Arjona, Teresa   +3 more
core   +1 more source

ROS1-ADGRG6: a case report of a novel ROS1 oncogenic fusion variant in lung adenocarcinoma and the response to crizotinib

BMC Cancer, 2019
Background ROS1 rearrangements are validated drivers in lung cancer, which have been identified in a small subset (1–2%) of patients with non-small cell lung cancer (NSCLC). To date, 18 fusion genes of ROS1 have been identified in NSCLC.
Shuguang Xu, Wenxian Wang, Chunwei Xu, Xingliang Li, Junhui Ye, Youcai Zhu, Ting Ge   +6 more
doaj   +1 more source

A novel CD74-ROS1 gene fusion in a patient with inflammatory breast cancer: a case report

Journal of Medical Case Reports, 2021
Background CD74-ROS1 fusion genes have been detected in non-small cell lung carcinomas (NSCLC), but not in inflammatory breast cancer. Case presentation Herein, we report a CD74-ROS1 fusion gene identified in a 64-year-old Chinese woman with inflammatory
Huiyu Hu, Nianhua Ding, Haiyan Zhou, Shouman Wang, Lili Tang, Zhi Xiao   +5 more
doaj   +1 more source

Case report: A novel reciprocal ROS1-CD74 fusion in a NSCLC patient partially benefited from sequential tyrosine kinase inhibitors treatment

Frontiers in Oncology, 2022
BackgroundThe clinical significance of majority oncogenic novel fusions is still unknown due to scarcity. Reciprocal ROS1 translocation is a rare form of ROS1 fusion and has not yet been clearly analyzed.Case presentationA 44-year-old Chinese woman with ...
Xugang Zhang, Baoming Wang, Chunyang Wang, Chengde Liao, Shiping Wang, Ran Cao, Tonghui Ma, Kun Wang   +7 more
doaj   +1 more source

Targeted genomic rearrangements using CRISPR/Cas technology [PDF]

, 2014
Genomic rearrangements are frequently observed in cancer cells but have been difficult to generate in a highly specific manner for functional analysis.
Choi, Peter S., Meyerson, Matthew
core   +1 more source

VarDict: a novel and versatile variant caller for next-generation sequencing in cancer research [PDF]

, 2016
Accurate variant calling in next generation sequencing (NGS) is critical to understand cancer genomes better. Here we present VarDict, a novel and versatile variant caller for both DNA- and RNA-sequencing data.
Ahdesmaki, Miika, Barrett, J. Carl, Chapman, Brad, Dougherty, Brian, Dry, Jonathan R., Hofmann, Oliver, Johnson, Justin, Lai, Zhongwu, Markovets, Aleksandra, McEwen, Robert   +9 more
core   +2 more sources