Results 261 to 270 of about 944,872 (298)

Targeted ROS Scavenging for Disease Therapies Using Nanomaterials

Advances in Materials
Reactive oxygen species (ROS) are essential by‐products of cellular metabolism and serve as key mediators in cell signaling and homeostasis. Excessive ROS production is associated with cellular damage and various diseases.
Ya-Jie Zhang, Ye Zhang, Ruizheng Liang, Jian-Hua Zou, R. Pei, Xiao-Yuan Chen   +5 more
semanticscholar   +1 more source

ROS‐Scavenging Hydrogels Synergize with Neural Stem Cells to Enhance Spinal Cord Injury Repair via Regulating Microenvironment and Facilitating Nerve Regeneration

Advanced Healthcare Materials, 2023
Although stem cell‐based therapy is recognized as a promising therapeutic strategy for spinal cord injury (SCI), its efficacy is greatly limited by local reactive oxygen species (ROS)‐abundant and hyper‐inflammatory microenvironments.
Dun Liu, Geng Lu, Bo Shi, Huanyu Ni, Jun Wang, Yong Qiu, Lin Yang, Ze-Zhang Zhu, Xuan Yi, Xiao Du, B. Shi   +10 more
semanticscholar   +1 more source

A Factor-Free Hydrogel with ROS Scavenging and Responsive Degradation for Enhanced Diabetic Bone Healing.

Small
In view of the increased levels of reactive oxygen species (ROS) that disturb the osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs), the repair of diabetic bone defects remains a great challenge.
Qin Zhang, Wei-Kai Chen, Guang-Feng Li, Zhixin Ma, Mengru Zhu, Qianmin Gao, Ke Xu, Xinru Liu, Wenyi Lu, Wen-Cai Zhang, Yan Wu, Zhongmin Shi, Jia-Chan Su   +12 more
semanticscholar   +1 more source

Design of Diselenide-Bridged Hyaluronic Acid Nano-antioxidant for Efficient ROS Scavenging to Relieve Colitis.

ACS Nano, 2022
Overproduction of reactive oxygen species (ROS), a key characteristic of inflammatory bowel disease (IBD), is responsible for dysregulation of signal transduction, inflammatory response, and DNA damage, which ultimately leads to disease progression and ...
Jia-Qi Xu, T. Chu, Tingting Yu, Nai-Shi Li, Chunling Wang, Chen Li, Yin-Long Zhang, Huan Meng, Guangjun Nie   +8 more
semanticscholar   +1 more source

An Immunoregulation Hydrogel with Controlled Hyperthermia‐Augmented Oxygenation and ROS Scavenging for Treating Diabetic Foot Ulcers

Advanced Functional Materials
Diabetic foot ulcers (DFUs), a serious and increasingly common chronic issue among diabetics, often do not respond well to generalized treatment strategies.
Xiao-Liang Qi, Xinxin Ge, Xiaojing Chen, Erya Cai, Ya-Jing Xiang, Hangbin Xu, Ying Li, Yulong Lan, Yizuo Shi, Hui Deng, Jian-Liang Shen   +10 more
semanticscholar   +1 more source

An electrospun scaffold functionalized with a ROS-scavenging hydrogel stimulates ocular wound healing.

Acta Biomaterialia, 2023
Ocular alkali burn is a serious ophthalmic emergency. Highly penetrative alkalis cause strong inflammatory responses leading to persistent epithelial defects, acute corneal perforation and severe scarring, and thereby persistent pain, loss of vision and ...
Xin Shi, Tong Zhou, Shenyu Huang, Yuejun Yao, Peifang Xu, Shaodan Hu, Chenxi Tu, Wei Yin, Changyou Gao, Juan Ye   +9 more
semanticscholar   +1 more source

Multi-responsive sodium hyaluronate/tannic acid hydrogels with ROS scavenging ability promote the healing of diabetic wounds.

International Journal of Biological Macromolecules
Oxidative stress caused by excessive reactive oxygen species (ROS) accumulation significantly hinders wound healing in patients with diabetes. Scavenging ROS and reducing inflammation are crucial for rapid healing. In this work, a multi-responsive sodium
Yu Liu, Meng Zhu, Jin-Zhao Ou, Ke-Jia Li, Xiaoyan Ju, Ye Tian, Zhong-Wei Niu   +6 more
semanticscholar   +1 more source

ROS Scavenging Nanozyme Modulates Immunosuppression for Sensitized Cancer Immunotherapy

Advanced Healthcare Materials, 2023
Myeloid‐derived suppressor cells (MDSCs) and tumor‐associated macrophages (TAMs), two immunosuppressive myeloid components within the tumor microenvironment (TME), represent fundamental barriers in cancer immunotherapy, whereas current nanomedicines ...
Wenjing Mo, Shujie Liu, Xiao-Zhi Zhao, Fayun Wei, Yu-Hang Li, X. Sheng, W. Cao, Meng Ding, Wenlong Zhang, Xiaoqing Chen, Longxiyu Meng, S. Yao, W. Diao, Hui Wei, Hong-Qian Guo   +14 more
semanticscholar   +1 more source

Self-Propelled Ultrasmall AuNPs-Tannic Acid Hybrid Nanozyme with ROS-Scavenging and Anti-Inflammatory Activity for Drug-Induced Liver Injury Alleviation.

Small, 2023
Developing nanomedicines with superior reactive oxygen species (ROS) scavenging capability has emerged as a promising strategy in treating ROS-related diseases, for example, drug-induced liver injury.
Chun-Yu Zhou, Liang Zhang, Zhong-Sheng Xu, Tao Sun, M. Gong, Yun Liu, Dong Zhang   +6 more
semanticscholar   +1 more source

A biphasic drug-releasing microneedle with ROS scavenging and angiogenesis for the treatment of diabetic ulcers.

Acta Biomaterialia
Diabetic ulcers are one of the common complications in diabetic patients. Delayed wound healing is associated with persistent pro-inflammatory M1 polarization, reduced angiogenesis and increased reactive oxygen species (ROS) in the microenvironment ...
Xinyue He, Lianghong Peng, Li-Ming Zhou, Huiling Liu, Yifan Hao, Yuhan Li, Zijin Lv, Bao-Hui Zeng, Xin-Min Guo, Rui Guo   +9 more
semanticscholar   +1 more source