Results 271 to 280 of about 944,872 (298)

Living Macrophage-Delivered Tetrapod PdH Nanoenzyme for Targeted Atherosclerosis Management by ROS Scavenging, Hydrogen Anti-inflammation, and Autophagy Activation.

ACS Nano, 2022
Atherosclerosis, driven by chronic inflammation in the artery walls, underlies several severe cardiovascular diseases. However, currently available anti-inflammatory-based strategies for atherosclerosis treatment suffer from compromised therapeutic ...
Ruizhi Hu, Chen Dai, Caihong Dong, Li Ding, Hui Huang, Yu Chen, Bo Zhang   +6 more
semanticscholar   +1 more source

Bio-adhesive and ROS-scavenging hydrogel microspheres for targeted ulcerative colitis therapy.

International journal of pharmaceutics, 2023
Ulcerative colitis (UC) as an important type of inflammatory bowel disease is a chronic disease characterized by intestinal dyshomeostasis. The UC treatment is challenged by the insufficiency of drug delivery and retention.
Qiqi Sun, Jun Chen, Quan Zhao, Ziyun He, Lei Tang, Yu-Jie Pu, Bingqin He   +6 more
semanticscholar   +1 more source

Design of a Zn-Based Nanozyme Injectable Multifunctional Hydrogel with ROS Scavenging Activity for Myocardial Infarction Therapy.

Acta Biomaterialia
The existing strategies for myocardial infarction therapy mainly focus on reinstating myocardial blood supply, often disregarding the intrinsic and intricate microenvironment created by elevated levels of reactive oxygen species (ROS) that accompanies ...
Yiming Zhong, Yi Yang, Yu-Ze Xu, Bei Qian, Shixing Huang, Qiang Long, Zhaoxi Qi, Xiao-Jun He, Yecen Zhang, Lihui Li, Wangxi Hai, Xinming Wang, Qiang Zhao, Xiaofeng Ye   +13 more
semanticscholar   +1 more source

Mechanics‐Resilient HA/SIS‐Based Composite Scaffolds with ROS‐Scavenging and Bacteria‐Resistant Capacity to Address Infected Bone Regeneration

Advanced Functional Materials
To address and regenerate infected bone defects complicated by issues such as inflammation and bone resorption, and to promote bone regeneration, this study focuses on the development of a composite scaffold with reactive oxygen species (ROS)‐scavenging ...
Zelong Song, Haichao Yu, Linhao Hou, Yuan Dong, Miaomiao Hu, Pengfei Wei, Wenchao Wang, Ding-Fei Qian, Shiqi Cao, Zhirong Zheng, Zhaoning Xu, Bo Zhao, Yiqian Huang, Wei Jing, Xue-Song Zhang   +14 more
semanticscholar   +1 more source

From ROS scavenging to boosted osseointegration: cerium-containing mesoporous bioactive glass nanoparticles functionalized implants in diabetes

Journal of Nanobiotechnology
Excessive production of reactive oxygen species (ROS) around titanium implants under diabetic conditions causes persistent inflammation, leading to poor osseointegration and even implant failure.
Xue Jiang, Jian-Xu Wei, Xin-Xin Ding, K. Zheng, Tian Zhou, Jun-Yu Shi, H. Lai, Shu-Jiao Qian, Xiao-Meng Zhang   +8 more
semanticscholar   +1 more source

ROS-scavenging lipid-based liquid crystalline as a favorable stem cell extracellular vesicles delivery vector to promote wound healing.

Journal of Controlled Release
Wound management is a critical clinical challenge due to the dynamic and complex pathological characteristics of inflammation, proliferation, and matrix remodeling. To address this challenge, the regulation and management of this multi-stage pathological
Lijun Li, Ying Wang, Yu-Qi Xu, Jian Xu, Yan-Qi Zhao, Zijian Cheng, Yuelin Fang, Yunqiu Miao, Xinxin Zhang   +8 more
semanticscholar   +1 more source

Multifunctional Microneedle Patch Based on Metal-Phenolic Network with Photothermal Antimicrobial, ROS Scavenging, Immunomodulatory, and Angiogenesis for Programmed Treatment of Diabetic Wound Healing.

ACS Applied Materials and Interfaces
In diabetic patients with skin injuries, bacterial proliferation, accumulation of reactive oxygen species (ROS) in the tissues, and impaired angiogenesis make wound healing difficult.
Ye Guo, Chuankai Zhang, Bingqing Xie, Wei Xu, Zihan Rao, Pei-Rong Zhou, Xue-Min Ma, Junliang Chen, Rui Cai, Gang Tao, Yun He   +10 more
semanticscholar   +1 more source

Prolonged, staged, and self-regulated methotrexate release coupled with ROS scavenging in an injectable hydrogel for rheumatoid arthritis therapy.

Journal of Controlled Release
Rheumatoid arthritis (RA) remains a formidable healthcare challenge due to its chronic nature and potential for irreversible joint damage. Methotrexate (MTX) is a cornerstone treatment for RA but carries significant risks of adverse effects with repeated
Mingshen Xu, Tingting Fu, Chenhui Zhang, Zhen An, Jincong Yan, Zhongzhong Lu, Hanfei Wu, Jihuan Liu, Lei Qiu, Lei Shi, Jun Lin, Yi Cao, R. Pei   +12 more
semanticscholar   +1 more source

3D Printing of Stiff, Tough, and ROS-Scavenging Nanocomposite Hydrogel Scaffold for in Situ Corneal Repair.

Acta Biomaterialia
Despite significant advancements in hydrogels in recent years, their application in corneal repair remains limited by several challenges, including unfitted curvatures, inferior mechanical properties, and insufficient reactive oxygen species (ROS ...
Tan Li, Xiaoyu Zhang, Li Ma, Xia Qi, Hong-Wei Wang, Qing-Jun Zhou, Xiuli Sun, Fuyan Wang, Long Zhao, Wei-Yun Shi   +9 more
semanticscholar   +1 more source

Advances in metal-organic framework-based nanozymes in ROS scavenging medicine

Nanotechnology
Reactive oxygen species (ROS) play important roles in regulating various physiological functions in the human body, however, excessive ROS can cause serious damage to the human body, considering the various limitations of natural enzymes as scavengers of
Zhong Xu, Liang Chen, Yan Luo, Yan-Mei Wei, Ning-Yuan Wu, Lan Luo, Yong-Biao Wei, Jin Huang   +7 more
semanticscholar   +1 more source