Results 11 to 20 of about 4,807 (280)

Rosetting in Plasmodium vivax: a cytoadhesion phenotype associated with anaemia. [PDF]

PLoS Neglected Tropical Diseases, 2013
BackgroundPlasmodium vivax can potentially lead to life-threatening episodes but the mechanisms underlying severe disease remain poorly defined. Cytoadhesion of infected erythrocytes may contribute to P.
Alejandro Marín-Menéndez, Azucena Bardají, Flor E Martínez-Espinosa, Camila Bôtto-Menezes, Marcus V Lacerda, Jon Ortiz, Pau Cisteró, Mireia Piqueras, Ingrid Felger, Ivo Müeller, Jaume Ordi, Hernando del Portillo, Clara Menéndez, Mats Wahlgren, Alfredo Mayor   +14 more
doaj   +7 more sources

Plasmodium falciparum rosetting protects schizonts against artemisinin [PDF]

EBioMedicine, 2021
Background Artemisinin (ART) resistance in Plasmodium falciparum is thought to occur during the early stage of the parasite's erythrocytic cycle. Here, we identify a novel factor associated with the late stage parasite development that contributes to ART
Wenn-Chyau Lee, Bruce Russell, Bernett Lee   +2 more
exaly   +4 more sources

Rosetting Responses of Plasmodium-infected Erythrocytes to Antimalarials. [PDF]

Am J Trop Med Hyg, 2022
ABSTRACT. In malaria, rosetting is a phenomenon involving the cytoadherence of uninfected erythrocytes to infected erythrocytes (IRBC) harboring the late erythrocytic stage of Plasmodium spp. Recently, artesunate-stimulated rosetting has been demonstrated to confer a survival advantage to P. falciparum late-stage IRBC.
Lee WC, Russell B, Lau YL, Nosten F, Rénia L.   +4 more
europepmc   +8 more sources

Molecular mechanisms and biological importance of Plasmodium falciparum erythrocyte rosetting

Memorias do Instituto Oswaldo Cruz, 1992
Rosetting, i.e. the spontaneous binding of uninfected to malaria infected erythrocytes and endothelial cytoadherence may hinder the blood flow and lead to serve Plasmodium falciparum malaria.
Mats Wahlgren, Johan Carlson, Helena Helmby, Iris Hedlund, Carl-Johan Treutiger   +4 more
doaj   +2 more sources

Rosette formation by Plasmodium vivax gametocytes favors the infection in Anopheles aquasalis [PDF]

Frontiers in Cellular and Infection Microbiology, 2023
Plasmodium vivax is a public health problem and the most common type of malaria outside sub-Saharan Africa. The capacity of cytoadhesion, rosetting, and liver latent phase development could impact treatment and disease control. Although the ability to P.
Luis Carlos Salazar Alvarez, Luis Carlos Salazar Alvarez, Luis Carlos Salazar Alvarez, Vanessa Carneiro Barbosa, Vanessa Carneiro Barbosa, Omaira Vera Lizcano, Omaira Vera Lizcano, Omaira Vera Lizcano, Djane Clarys Baia da Silva, Djane Clarys Baia da Silva, Djane Clarys Baia da Silva, Djane Clarys Baia da Silva, Djane Clarys Baia da Silva, Rosa Amélia Gonçalves Santana, Rosa Amélia Gonçalves Santana, Rosa Amélia Gonçalves Santana, Camila Fabbri, Camila Fabbri, Camila Fabbri, Paulo Filemon Paoluci Pimenta, Paulo Filemon Paoluci Pimenta, Paulo Filemon Paoluci Pimenta, Wuelton Marcelo Monteiro, Wuelton Marcelo Monteiro, Letusa Albrecht, Letusa Albrecht, Marcus Vinicius Guimarães de Lacerda, Marcus Vinicius Guimarães de Lacerda, Marcus Vinicius Guimarães de Lacerda, Fabio Trindade Maranhão Costa, Fabio Trindade Maranhão Costa, Stefanie Costa Pinto Lopes, Stefanie Costa Pinto Lopes, Stefanie Costa Pinto Lopes   +33 more
doaj   +2 more sources

The role of periostin (OSF-2) in the cytoadherence phenomena mediated by malaria parasites [PDF]

Frontiers in Cellular and Infection Microbiology
IntroductionThe pathogenesis of severe malaria is primarily attributed to the cytoadherence properties of Plasmodium-infected erythrocytes (IRBC), which include rosetting and IRBC-endothelial cytoadherence.
Zhi-Ying Phong, Zhi-Ying Phong, Joo-Yie Chin, Yee Ling Ng, Nurul Izza Zakaria, Siti Nur Athirah-Azman, Siti Nur Athirah-Azman, Varakorn Kosaisavee, Laurent Rénia, Laurent Rénia, Laurent Rénia, Wenn-Chyau Lee, Wenn-Chyau Lee   +12 more
doaj   +2 more sources

Effect of periostin (OSF-2) on phagocytosis of Plasmodium-infected erythrocytes [PDF]

Frontiers in Microbiology
IntroductionPhagocytosis is a pivotal component of the human innate immune defense against malaria. This essential defense mechanism is often modulated by various host-derived soluble factors.
Joo-Yie Chin, Muhammed-Nur-Iman Mohammed-Syafiei, Yi-Jun Lim, Gordon Xue-Zhen Chong, Muhammad-Nasreen Suhaimi, Zhi-Ying Phong, Zhi-Ying Phong, Yee Ling Ng, Yee-Ling Lau, I-Ching Sam, Laurent Rénia, Laurent Rénia, Laurent Rénia, Wenn-Chyau Lee, Wenn-Chyau Lee   +14 more
doaj   +2 more sources

Rosetting revisited: a critical look at the evidence for host erythrocyte receptors inPlasmodium falciparumrosetting [PDF]

Parasitology, 2019
AbstractMalaria remains a major cause of mortality in African children, with no adjunctive treatments currently available to ameliorate the severe clinical forms of the disease. Rosetting, the adhesion of infected erythrocytes (IEs) to uninfected erythrocytes, is a parasite phenotype strongly associated with severe malaria, and hence is a potential ...
Fiona McQuaid, J. Alexandra Rowe
openaire   +4 more sources

Identification of novel PfEMP1 variants containing domain cassettes 11, 15 and 8 that mediate the Plasmodium falciparum virulence-associated rosetting phenotype. [PDF]

PLoS Pathogens
Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) is a diverse family of variant surface antigens, encoded by var genes, that mediates binding of infected erythrocytes to human cells and plays a key role in parasite immune evasion and malaria
Florence E McLean, Brian R Omondi, Nouhoum Diallo, Stanley Otoboh, Carolyne Kifude, Abdirahman I Abdi, Rivka Lim, Thomas D Otto, Ashfaq Ghumra, J Alexandra Rowe   +9 more
doaj   +2 more sources

Non-O ABO blood group genotypes differ in their associations with Plasmodium falciparum rosetting and severe malaria. [PDF]

PLoS Genetics, 2023
Blood group O is associated with protection against severe malaria and reduced size and stability of P. falciparum-host red blood cell (RBC) rosettes compared to non-O blood groups. Whether the non-O blood groups encoded by the specific ABO genotypes AO,
D Herbert Opi, Carolyne M Ndila, Sophie Uyoga, Alex W Macharia, Clare Fennell, Lucy B Ochola, Gideon Nyutu, Bethseba R Siddondo, John Ojal, Mohammed Shebe, Kennedy O Awuondo, Neema Mturi, Norbert Peshu, Benjamin Tsofa, Gavin Band, Kathryn Maitland, Dominic P Kwiatkowski, Kirk A Rockett, Thomas N Williams, J Alexandra Rowe   +19 more
doaj   +2 more sources