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Metabolism of Rosmarinic Acid in Rats
Journal of Natural Products, 1998The urine of rats administered rosmarinic acid (7) orally contained seven metabolites, which were identified as trans-caffeic acid 4-O-sulfate (1), trans-m-coumaric acid 3-O-sulfate (2), trans-ferulic acid 4-O-sulfate (3), trans-caffeic acid (4), m-hydroxyphenylpropionic acid (5), trans-m-coumaric acid (6), and unchanged rosmarinic acid (7) by ...
T, Nakazawa, K, Ohsawa
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Caffeic acid and rosmarinic acid contents in genus Perilla
Journal of Natural Medicines, 2020Caffeic acid and rosmarinic acid are common components of Labiatae plants, such as shiso (Perilla frutescens Britton var. crispa W. Deane) and Boraginaceae plants. These compounds have various pharmacological activities, such as anti-inflammatory, anti-anxiety, and anti-depressive activities, but the content of these compounds in perilla has not been ...
Yuya Deguchi, Michiho Ito
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Redox Behaviour of Verbascoside and Rosmarinic Acid
Combinatorial Chemistry & High Throughput Screening, 2013The electrochemical oxidation mechanisms of rosmarinic acid (RA) and verbascoside (VB), both caffeic acid esters with two catechol moieties, were investigated. The redox mechanism is associated with the oxidation of the catechol groups, and was studied over a wide pH range by cyclic, differential pulse and square wave voltammetry, using a glassy carbon
Eric de Souza, Gil +2 more
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The effect of rosmarinic acid on the prevention of myringosclerosis
International Journal of Pediatric Otorhinolaryngology, 2019Myringosclerosis commonly occurs as a long-term complication of ventilation during the treatment of otitis media. We aimed to determine the effects of rosmarinic acid as an antioxidant on experimentally induced myringosclerosis.Twenty-four male Sprague-Dawley rats, weighing 250-300 g, were unilaterally myringotomized and randomly separated into three ...
Doğukan Özdemir +6 more
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Rosmarinic Acid as Potential Anti-Inflammatory Agent
Reviews on Recent Clinical Trials, 2018Rosmarinus officinalis L. (Lamiaceae), popularly known as rosemary, is used for food flavoring, and in folk medicine, as an antispasmodic, analgesic, anti-rheumatic, diuretic, and antiepileptic agent. Rosemary is an herb widely used in folk medicine, cosmetics, and phytotherapy and for flavoring of food products.
Colica C. +4 more
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Attenuation of Tacrine Combined With Rosmarinic Acid
Phytochemical AnalysisABSTRACTBackgroundAlzheimer's disease (AD) is one of the most common forms of dementia among the elderly in the world. With the increase of human life expectancy, its incidence is also increasing year by year. Tacrine (TAC) is the first acetylcholine inhibitor approved for the treatment of AD.
Manyv Zheng +6 more
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Synthesis of rosmarinic acid analogues in Escherichia coli
Biotechnology Letters, 2015To produce rosmarinic acid analogues in the recombinant Escherichia coli BLRA1, harboring a 4-coumarate: CoA ligase from Arabidopsis thaliana (At4CL) and a rosmarinic acid synthase from Coleus blumei (CbRAS).Incubation of the recombinant E. coli strain BLRA1 with exogenously supplied phenyllactic acid (PL) and analogues as acceptor substrates, and ...
Yibin, Zhuang +5 more
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Rosmarinic acid production in Coleus cell cultures
Planta, 1977Cell suspension cultures of Coleus blumei Benth. have been found to accumulate 8-11% of their dry weight as rosmarinic acid (α-O-caffeoyl-3,4-dihydroxyphenyl-lactic acid). Actively-growing tissue converts >20% of exogenously supplied phenylalanine and tyrosine to the caffeoyl ester and this high rate of synthesis coincides with an increase in ...
A, Razzaque, B E, Ellis
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New trends in biotechnological production of rosmarinic acid
Biotechnology Letters, 2014Rosmarinic acid (RA), an ester of caffeic acid and 3,4-dihydroxyphenyl lactic acid, is widely distributed in the plant kingdom. Interest in it is growing due to its promising biological activities, including cognitive-enhancing effects and slowing the development of Alzheimer's disease, cancer chemoprotection or anti-inflammatory activity, among others.
Khojasteh A +4 more
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Rosmarinic acid and its derivatives: biotechnology and applications
Critical Reviews in Biotechnology, 2011Rosmarinic acid (RA) is one of the first secondary metabolites produced in plant cell cultures in extremely high yields, up to 19% of the cell dry weight. More complex derivatives of RA, such as rabdosiin and lithospermic acid B, later were also obtained in cell cultures at high yields.
Victor P, Bulgakov +2 more
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