Results 11 to 20 of about 58,009 (170)

Optotagging and characterization of GABAergic rostral ventromedial medulla (RVM) neurons [PDF]

Molecular Pain
The transmission of nociceptive and pruriceptive signals in the spinal cord is greatly influenced by descending modulation from brain areas such as the rostral ventromedial medulla (RVM). Within the RVM three classes of neurons have been discovered which
Taylor Follansbee, Henry Le Chang, Mirela Iodi Carstens, Yun Guan, Earl Carstens, Xinzhong Dong   +5 more
doaj   +6 more sources

Inhibition of itch by neurokinin 1 receptor (Tacr1) -expressing ON cells in the rostral ventromedial medulla in mice [PDF]

eLife, 2022
The rostral ventromedial medulla (RVM) is important in descending modulation of spinal nociceptive transmission, but it is unclear if the RVM also modulates spinal pruriceptive transmission.
Taylor Follansbee, Dan Domocos, Eileen Nguyen, Amanda Nguyen, Aristea Bountouvas, Lauren Velasquez, Mirela Iodi Carstens, Keiko Takanami, Sarah E Ross, Earl Carstens   +9 more
doaj   +2 more sources

The Rostral Ventromedial and Lateral Medulla Are the Major Areas Responsive to Lung Cancer Progression among Brainstem Lung-Innervating Nuclei

Brain Sciences, 2022
In recent years, the information crosstalk between the central nervous system and the periphery has been a hot topic, such as the brain–gut axis, brain–lung axis, etc.
Mo Chen, Yingfu Jiao, Yumiao Shi, Saihong Xu, Dan Tang, Sihan Chen, Po Gao, Xindi Zhang, Xiaojing Zhao, Mengmeng Cai, Weifeng Yu, Kangjie Xie   +11 more
doaj   +2 more sources

Neuronal Loss in the Rostral Ventromedial Medulla in a Rat Model of Neuropathic Pain [PDF]

The Journal of Neuroscience, 2011
Cell death has been reported in the CNS in models of neuropathic pain (Sugimoto et al., 1990; Whiteside and Munglani, 2001; Scholz et al., 2005; Fuccio et al., 2009). In our present study, we examined the effects of spinal nerve ligation (SNL) on the number of neurons in the rostral ventromedial medulla (RVM), a brainstem region involved in modulation ...
Mai Lan, Leong, Ming, Gu, Rebecca, Speltz-Paiz, Eleanor I, Stahura, Neli, Mottey, Clifford J, Steer, Martin, Wessendorf   +6 more
openaire   +3 more sources

Targeting Histamine H4 Receptor in the Rostral Ventromedial Medulla to Relieve Hypertension

Advanced Science
Refractory hypertension often involves centrally driven sympathetic augmentation. Yet effective central targets for the treatment of hypertension are still scarce.
Ying Shi, Yang‐Xun Zhang, Jun‐Yi Chen, Sai Ma, Wei‐Xuan Xue, Wei Li, Qian‐Xiao Li, Bo Song, Ya‐Ting Li, Hong‐Yu Ma, Shu‐Tao Xie, Hong‐Zhao Li, Di‐Jun Chen, Qi‐Peng Zhang, Hui‐Jie Ma, Jian‐Jun Wang, Lei Yu, Xiao‐Yang Zhang, Jing‐Ning Zhu   +18 more
doaj   +3 more sources

Administration of orexin receptor 1 antagonist into the rostral ventromedial medulla increased swim stress-induced antinociception in rat [PDF]

Iranian Journal of Basic Medical Sciences, 2016
Objective(s): Intracerebroventricular injection of orexin-A (hypocretin-1) antagonist has been shown to inhibit stress-induced analgesia. However the locations of central sites that may mediate these effects have not been totally demonstrated. This study
Neda Soliemani, Alireza Moslem, Ali Shamsizadeh, Hassan Azhdari-Zarmehri   +3 more
doaj   +2 more sources

Neurochemical properties of BDNF-containing neurons projecting to rostral ventromedial medulla in the ventrolateral periaqueductal gray [PDF]

Frontiers in Neural Circuits, 2014
The periaqueductal gray (PAG) modulates nociception via a descending pathway that relays in the rostral ventromedial medulla (RVM) and terminates in the spinal cord.
Jun-Bin eYin, Huang-Hui eWu, Yu-Lin eDong, Ting eZhang, Jian eWang, Yong eZhang, Yan-Yan eWei, Ya-Cheng eLu, Sheng-Xi eWu, Wen eWang, Yun-Qing eLi   +10 more
doaj   +2 more sources

Circuitry Underlying AntiOpioid Actions of Orphanin FQ in the Rostral Ventromedial Medulla

Journal of Neurophysiology, 1997
Heinricher, M. M., S. McGaraughty, and D. K. Grandy. Circuitry underlying antiopioid actions of orphanin FQ in the rostral ventromedial medulla. J. Neurophysiol. 78: 3351–3358, 1997. Several laboratories recently identified a 17 amino-acid peptide, termed “nociceptin” or “orphanin FQ (OFQ)”, as the endogenous ligand for the LC132 (or “opioid receptor ...
M M, Heinricher, S, McGaraughty, D K, Grandy   +2 more
openaire   +3 more sources

Permanent lesion in rostral ventromedial medulla potentiates swim stress-induced analgesia in formalin test [PDF]

Iranian Journal of Basic Medical Sciences, 2014
Objective(s): There are many reports about the role of rostral ventromedial medulla (RVM) in modulating stress-induced analgesia (SIA). In the previous study we demonstrated that temporal inactivation of RVM by lidocaine potentiated stress-induced ...
Ali Shamsizadeh, Neda Soliemani, Mohammad Mohammad-Zadeh, Hassan Azhdari-   +3 more
doaj   +1 more source

Orexin-A Modulates Firing of Rat Rostral Ventromedial Medulla Neurons: An In Vitro Study [PDF]

Cell Journal, 2015
The rostral ventromedial medulla (RVM) acts a key role in the descending inhibitory pain modulation. Neuropeptide orexin-A (ORXA) is confined to thousands of neurons in the lateral hypothalamus (LH).
Hassan Azhdari-Zarmehri, Saeed Semnanian, Yaghoub Fathollahi   +2 more
doaj   +1 more source