Results 21 to 30 of about 58,009 (170)

Purinergic receptor immunoreactivity in the rostral ventromedial medulla [PDF]

Neuroscience, 2009
The rostral ventromedial medulla (RVM) has long been recognized to play a pivotal role in nociceptive modulation. Pro-nociception within the RVM is associated with a distinct functional class of neurons, ON-cells that begin to discharge immediately before nocifensive reflexes.
L N, Close, J S, Cetas, M M, Heinricher, N R, Selden   +3 more
openaire   +2 more sources

Astroglia are a possible cellular substrate of angiotensin(1-7) effects in the rostral ventrolateral medulla [PDF]

, 2010
AIMS: Angiotensin(1-7) (Ang1-7) acting at the level of the rostral ventrolateral medulla (RVLM) affects arterial pressure. The cellular substrate of Ang1-7 remains unknown.
Tang, F, Fang Guo, Feige Tang, Samantha Lane, Souslova, E A, Ekaterina A. Souslova, Paton, JFR, Lane, S, Sergey Kasparov, Dmitriy M. Chudakov, Kasparov, S, Guo, F, Chudakov, D M, Liu, B, Beihui Liu, Julian F.R. Paton   +15 more
core   +1 more source

Lesions in rostral ventromedial or rostral ventrolateral medulla block neurogenic hypertension. [PDF]

Hypertension, 1994
Neurogenic hypertension results from the removal of inhibitory baroreceptor afferent input to vasomotor systems in the central nervous system. We sought to determine whether the bilateral destruction of neurons in the rostral ventrolateral or rostral ventromedial medulla, made using microinjections of N-methyl-D-aspartic acid (30 nmol in 200 nL), would
K J, Varner, E C, Vasquez, M J, Brody
openaire   +2 more sources

Bulbospinal nociceptive ON and OFF cells related neural circuits and transmitters

Frontiers in Pharmacology, 2023
The rostral ventromedial medulla (RVM) is a bulbospinal nuclei in the descending pain modulation system, and directly affects spinal nociceptive transmission through pronociceptive ON cells and antinociceptive OFF cells in this area.
Bingxue Peng, Bingxue Peng, Yingfu Jiao, Yingfu Jiao, Yunchun Zhang, Yunchun Zhang, Shian Li, Shian Li, Sihan Chen, Sihan Chen, Saihong Xu, Saihong Xu, Po Gao, Po Gao, Yinghui Fan, Yinghui Fan, Weifeng Yu, Weifeng Yu   +17 more
doaj   +1 more source

Altered glial glutamate transporter expression in descending circuitry and the emergence of pain chronicity

Molecular Pain, 2019
Background The glutamate type 1 transporter (GLT1) plays a major role in glutamate homeostasis in the brain. Although alterations of GLT1 activity have been linked to persistent pain, the significance of these changes is poorly understood.
Wei Guo, Satoshi Imai, Shiping Zou, Jiale Yang, Mineo Watanabe, Jing Wang, Ronald Dubner, Feng Wei, Ke Ren   +8 more
doaj   +1 more source

Trigeminal-Rostral Ventromedial Medulla circuitry is involved in orofacial hyperalgesia contralateral to tissue injury

Molecular Pain, 2012
Background Our previous studies have shown that complete Freund’s adjuvant (CFA)-induced masseter inflammation and microinjection of the pro-inflammatory cytokine interleukin-1β (IL-1β) into the subnucleus interpolaris/subnucleus caudalis transition zone
Chai Bryan, Guo Wei, Wei Feng, Dubner Ronald, Ren Ke   +4 more
doaj   +1 more source

GPER in the rostral ventromedial medulla is essential for mobilizing descending inhibition of itch [PDF]

, 2021
Chronic itch is a troublesome condition and often difficult to cure. Emerging evidence suggests that the periaqueductal gray-rostral ventromedial medulla (PAG-RVM) pathway may play an important role in regulation of itch, but the cellular organization ...
Qian, Jiahong, Jiao, Yingfu, Meng, Li, Wu, Meimei, WU, CHANGHAO, Dong, Li, Shi, Xueyin, Zhang, Guohua, Luo, Ping, Rong,  Weifang, Gao, Ting, Gao, Po, Ding, Xiaowei, ZHENG, YI, Meimei Wu, Guohua Zhang, Weifang Rong, Xueyin Shi, Yi Zheng, Po Gao, Yingfu Jiao, Ting Gao, Ping Luo, Jiahong Qian, Xiaowei Ding, Li Dong, Li Meng, Changhao Wu   +27 more
core   +1 more source

Acute nociceptive stimuli rapidly induce the activity of serotonin and noradrenalin neurons in the brain stem of awake mice

IBRO Reports, 2019
Nociception is an important type of perception that has major influence on daily human life. There are some descending pathways related to pain management and modulation, which are collectively known as the descending antinociceptive system (DAS ...
Shunpei Moriya, Akira Yamashita, Ryusei Nishi, Yoko Ikoma, Akihiro Yamanaka, Tomoyuki Kuwaki   +5 more
doaj   +1 more source

Contribution of the rostral ventromedial medulla to post-anxiety induced hyperalgesia

Brain Research, 2012
Rats exposed to an elevated plus maze (EPM) with four open arms display antinociception while on the maze and hyperalgesia immediately upon removal. Little is known about the neural mechanisms underlying EPM-induced antinociception and the subsequent hyperalgesia except that the antinociception is not mediated by endogenous opioids.
Cornelio, Alianda Maira, Nunes-de-Souza, Ricardo Luiz, Morgan, Michael M.   +2 more
openaire   +4 more sources

Lesions of the periaqueductal gray and rostral ventromedial medulla disrupt antinociceptive but not cardiovascular aversive conditional responses

, 1994
The presentation of an auditory stimulus that signals a noxious event such as foot shock results in the simultaneous expression of multiple aversive conditional responses (CRs), which include a transient elevation of arterial blood pressure (ABP) and an ...
SA Tershner, FJ Helmstetter
core   +1 more source