Results 41 to 50 of about 58,009 (170)

Orofacial pain disorder or trigeminal autonomic cephalalgia? Insights into pathophysiology and implications in medicine and dentistry

Headache: The Journal of Head and Face Pain, EarlyView.
There are some headache disorders known as trigeminal autonomic cephalalgias (TACs). When these “headaches” are localized in the mid‐face region, they are known as “trigeminal autonomic orofacial pains” (TAOPs), and they can mimic other types of face pains including dental pain, which puts the patient at risk of receiving treatments that are incorrect.
Marcela Romero‐Reyes, Simon Akerman
wiley   +1 more source

The percentages of neurons in the ventromedial medulla that were retrogradely labeled from the spinal cord and contained GlyT2 and/or GAD67 mRNAs.

, 2013
Histograms showing the percentages of retrogradely labeled neurons in the ventromedial medulla that contained GAD67, GlyT2, and GlyT2 and/or GAD67 mRNAs after fluorescent microsphere injections in the cervical spinal cord (A), in the lumbar dorsal horn ...
Somesh K. Kohli (324278), Mehdi Hossaini (324275), Jan C. Holstege (324281), Jacqueline A. C. Goos (324276)   +3 more
core   +1 more source

Placebo and nocebo effects on pain through the lens of the predictive brain: Neurobiological mechanisms and translational implications

Experimental Physiology, EarlyView.
Abstract Placebo and nocebo effects on pain provide a model for investigating how cognitive and contextual factors modulate the physiological processes underlying nociception and its regulation. However, existing accounts remain fragmented and lack a unifying mechanistic framework linking brain, behaviour and autonomic responses.
Denisa Adina Zamfira, Tommaso Fassina, Kamil Zaworski, Elisa Carlino, Giacomo Rossettini   +4 more
wiley   +1 more source

Modulation of pain by affective touch: effects of childhood trauma, depression, chronic pain, and spinal segment

The Journal of Physiology, EarlyView.
Abstract figure legend Patients with fibromyalgia and no‐pain controls completed questionnaire ratings of chronic pain, childhood trauma, anxiety and depression. During the first session a conditioned pain modulation task was administered, with heat pain applied via thermode and cold pain via cold water‐bath.
Benedetta Albinni, Marisa Zimmerman, Vincent Alasha, Jacob Ross, Lindsey Crankshaw, Emrys Jones, Jeffery Lewis, Sandy R. Hu, Nathaniel Schuster, Laura Case   +9 more
wiley   +1 more source

Parallel cortical-brainstem pathways to attentional analgesia

NeuroImage, 2021
Pain demands attention, yet pain can be reduced by focusing attention elsewhere. The neural processes involved in this robust psychophysical phenomenon, attentional analgesia, are still being defined.
Valeria Oliva, Rob Gregory, Wendy-Elizabeth Davies, Lee Harrison, Rosalyn Moran, Anthony E. Pickering, Jonathan C.W. Brooks   +6 more
doaj   +1 more source

Neurons in the ventromedial medulla that were retrogradely labeled from the spinal cord and neurons labeled for GlyT2 and/or GAD67 mRNAs.

, 2013
Fluorescence micrographs showing neurons in the ventromedial medulla retrogradely labeled with fluorescent microspheres (red) from the spinal cord and neurons labeled for GlyT2 and/or GAD67 mRNA (green) using FISH.
Somesh K. Kohli (324278), Mehdi Hossaini (324275), Jan C. Holstege (324281), Jacqueline A. C. Goos (324276)   +3 more
core   +1 more source

Impaired endocannabinoid signalling in the rostral ventromedial medulla underpins genotype-dependent hyper-responsivity to noxious stimuli

, 2020
Pain is both a sensory and an emotional experience, and is subject to modulation by a number of factors including genetic background modulating stress/affect. The Wistar-Kyoto (WKY) rat exhibits a stress-hyper-responsive and depressive-like phenotype and
Madasu, Manish K., Okine, Bright N., Olango, Weredeselam M., Finn, David P., Coyle, Kathleen, Harhen, Brendan, Roche, Michelle, Rea, Kieran, McGuire, Iseult C.   +8 more
core   +1 more source

Intrinsic pH chemosensitivity of acutely dissociated medullary serotonergic and retrotrapezoid neurones

The Journal of Physiology, EarlyView.
Abstract figure legend Central respiratory chemoreceptors (CRCs) are critical for maintaining normal systemic levels of pH and PCO2. A CRC must respond to pH via intrinsic mechanisms. Here we quantified intrinsic chemosensitivity of medullary 5‐HT neurones and retrotrapezoid nucleus (RTN) neurones using acute dissociation.
Yuanming Wu, Eduardo Bravo, George Bradley Richerson   +2 more
wiley   +1 more source

Voluntary wheel running alleviates and prevents long-lasting mechanical hyperalgesia induced by short-term vertical chronic restraint stress

Heliyon
Exercise reduces pain sensitivity, a phenomenon termed exercise-induced hypoalgesia (EIH). EIH is a non-pharmacological therapy for pain, and its effects on neuropathic and muscle pain have been studied in animal models.
Hiroki Imbe, Hayato Ihara, Katsuya Kami, Masanori Nakata, Moritoshi Hirono   +4 more
doaj   +1 more source

NSAIDs, Opioids, Cannabinoids and the Control of Pain by the Central Nervous System

Pharmaceuticals, 2010
Nonsteroidal anti-inflammatory drugs (NSAIDs) act upon peripheral tissues and upon the central nervous system to produce analgesia. A major central target of NSAIDs is the descending pain control system.
Horacio Vanegas, Enrique Vazquez, Victor Tortorici   +2 more
doaj   +1 more source