Results 61 to 70 of about 58,009 (170)

Spinal and supraspinal mechanisms of chronic itch: from neuronal circuits to the neuro-immune-microbial axis

Frontiers in Medicine
Itch is an unpleasant sensation that evokes scratching behavior; when it becomes chronic, it severely impairs quality of life, and current therapies have limited efficacy against non-histaminergic itch.
Shengrun Gao, Mengyan Liu, Mengyan Liu, Ziyue Qi, Ziyue Qi, Yuheng Li, Yu Xue, Yu Xue, Chengjie Gao   +8 more
doaj   +1 more source

Brain‐Wide Connectivity and Topographic Organization of Leptin Receptor Neurons in the Dorsomedial Hypothalamus

CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.
Whole‐brain input–output mapping reveals that DMDLepRb and DMHLepRb neurons share a highly conserved global connectivity architecture yet exhibit local connection biases: DMDLepRb neurons preferentially integrate arousal and defensive signals, whereas DMHLepRb neurons favor viscerosensory and metabolic inputs, uncovering a principle of conserved global
Yaxin Hao, Xiang Zhang, Danyang Zhao, Haixing Zhong, Yongqiang Chen, Heming Li, Minghui Ren, Mengchu Zhu, Fang Yuan   +8 more
wiley   +1 more source

Morphological evidence for a neurotensinergic periaqueductal gray-rostral ventromedial medulla-spinal dorsal horn descending pathway in rat

Frontiers in Neuroanatomy, 2014
Neurotensin (NT) is an endogenous neuropeptide that exerts potent opioid-independent analgesic effects, most likely via the type 2 NT receptor (NTR2). Previous morphological and electrophysiological studies suggested that the NT-NTR2 system is primarily ...
Jian eWang, Hua eZhang, Yu-Peng eFeng, Hua eMeng, Li-Ping eWu, Wen eWang, Hui eLi, Ting eZhang, Jin-Shan eZhang, Yun-Qing eLi   +9 more
doaj   +1 more source

Pain Severity Trajectories and Patient Profiles in Chronic Pain Patients Treated with Cannabis‐Based Medicinal Products: A k‐Means Clustering Analysis of the UK Medical Cannabis Registry

The Journal of Clinical Pharmacology, Volume 66, Issue 10, October 2026.
Abstract Cannabis‐based medicinal products (CBMPs) are increasingly prescribed for chronic pain, yet the supporting evidence remains limited and the extent to which patients differ in their response is poorly understood. This study applied longitudinal k‐means clustering to pain‐severity trajectories in patients treated with CBMPs for chronic pain to ...
Simon Erridge, Aritra Datta, Aditya Mukherjee, Dhruv Vasooja, Ross Coomber, Sushil Beri, Shaheen A. Khan, Mark W. Weatherall, Michael W. Platt, James J. Rucker, Pedro A. M. Mediano, Mikael H. Sodergren   +11 more
wiley   +1 more source

Subregions of rostral ventral medulla control arterial pressure and regional hemodynamics

, 1989
The cardiovascular effects of inactivating rostral ventromedial medulla (RVMM) under conditions of normal (2.5 ml) and reduced (1.5 ml) tidal volume were studied in urethan-anesthetized rats.
B. F. Cox, M. J. Brody
core   +1 more source

Fumarate and Its Esters: Physiology, Pathology, Molecular Mechanisms, Diseases, and Therapy

MedComm, Volume 7, Issue 10, October 2026.
Fumarate is an endogenous immunometabolite that regulates metabolism, redox homeostasis, and inflammation. Although fumaric acid esters (FAEs) share several molecular targets with fumarate, their distinct physicochemical properties confer unique biological activities and therapeutic applications.
Peng Zhu, Mengling You, Yi Zeng, Jinglin Zhang, Si Chen, Rong Rong, Xiaobo Xia   +6 more
wiley   +1 more source

Dose-Dependent Effect of GABAA System on Antinociception Actions of Cuneiformis Nucleus in Brain Stem [PDF]

Background and Objective: It's been established that midbrain region namely rostral ventromedial medulla (RVM) is the coring point of modulation of pain.
شیخکانلوی میلان, حمید
core  

Hyperalgesia and sensitization of dorsal horn neurons following activation of NK-1 receptors in the rostral ventromedial medulla

, 2017
Neurons in the rostral ventromedial medulla (RVM) project to the spinal cord and are involved in descending modulation of pain. Several studies have shown that activation of neurokinin-1 (NK-1) receptors in the RVM produces hyperalgesia, although the ...
Janneta Tabakov, Patrick Malecha, Joseph Noack, Glenn J. Giesler, Donald A. Simone, Sergey G. Khasabov   +5 more
core   +1 more source

Analysis of brainstem activitywith fMRI during low-level of pain- a feasibility study with innocuous cold stimuli

Diyala Journal of Medicine, 2019
Background: In functional magnetic resonance imaging (fMRI)studies, there are limitedpublished data on the functional map of the human brainstem. Objective: The primary goals of this pilot study were to assess the feasibility and  to map  the  neural
Haydar A Al-Shimmari, Gareth J Noble, Richard P Hugtenbur, Stephen S Johnston   +3 more
doaj   +2 more sources

Neuropathic Pain: From Mechanisms to Therapeutic Interventions

MedComm, Volume 7, Issue 10, October 2026.
Neuropathic pain arises from peripheral nerve injury, central sensitization, neurotransmitter imbalance, neuroimmune activation, and maladaptive circuit remodeling. Clinical phenotyping and multimodal imaging can identify dominant peripheral and central mechanisms.
Yaling Dai, Mengquan Tan, Man Yuan, Huixian Zhou, Qin Xie, Jiling Zeng, Yixin Yang, Xinran He, Siyuan Song   +8 more
wiley   +1 more source