Results 1 to 10 of about 20,083 (116)

Rosuvastatin attenuates tubulointerstitial fibrosis by targeting the HOXA13 USAG1 BMP7 pathway [PDF]

Scientific Reports
Statins act as antifibrotic agents but their mechanism is unclear. Therefore, we aimed to evaluate the antifibrotic effects of rosuvastatin in a chronic kidney fibrosis model in vivo and transforming growth factor-β1 (TGF-β1)-stimulated Madin-Darby ...
Donghwan Oh, Hyo Jeong Kim, Seok-hyung Kim, Soo Hyun Kim, Tae Yeon Kim, Hoon Young Choi, Hyunwook Kim, Hyung Jong Kim, Hyeong Cheon Park   +8 more
doaj   +2 more sources

Rosuvastatin protects against oxLDL-induced endothelial cell oxidative stress and attenuates atherosclerotic plaque formation in ApoE-/- mice through the NF-κB pathway. [PDF]

PLoS ONE
Cardiovascular disease is one of the diseases with the highest global incidence and mortality rates, and atherosclerosis is its basic cause. Endothelial dysfunction induced by risk factors such as lipid oxidation or inflammatory stimulation is a critical
Yichen Wu, Jiaqi Ke, Jiaxin Lv, Chaowei Cao, Chunxian Zhou, Lili Wu, Qiyang Zhou   +6 more
doaj   +2 more sources

Rosuvastatin suppresses TNF-α-induced matrix catabolism, pyroptosis and senescence via the HMGB1/NF-κB signaling pathway in nucleus pulposus cells

Acta Biochimica et Biophysica Sinica, 2023
Intervertebral disc degeneration is mainly caused by irregular matrix metabolism in nucleus pulposus cells and involves inflammatory factors such as TNF-α.
Chen Weijian, Deng Zhihuai, Zhu Jianxiong, Yuan Liang, Li Shuangxing, Zhang Yangyang, Wu Jiajun, Huang Zhengqi, Qin Tianyu, Ye Wei   +9 more
doaj   +1 more source

Rosuvastatin Treatment Affects Both Basal and Glucose-Induced Insulin Secretion in INS-1 832/13 Cells. [PDF]

PLoS ONE, 2016
Rosuvastatin is a member of the statin family. Like the other statins it is prescribed to lower cholesterol levels and thereby reduce the risk of cardiovascular events.
Vishal A Salunkhe, Olof Elvstam, Lena Eliasson, Anna Wendt   +3 more
doaj   +1 more source

Antihypertensive effects of rosuvastatin in patients with hypertension and dyslipidemia: A systemic review and meta-analysis of randomized studies.

PLoS ONE, 2021
Some studies have suggested the antihypertensive effects of statins, a class of lipid-lowering agents, particularly in patients with hypertension. However, the evidence for the role of statins in blood pressure (BP) lowering is controversial, and no meta-
Sungjae Lee, Seungwon Yang, Min Jung Chang   +2 more
doaj   +1 more source

High doses of rosuvastatin induce impaired branched‐chain amino acid catabolism and lead to insulin resistance

Experimental Physiology, 2023
Accumulating evidence indicates that patients treated with rosuvastatin have an increased risk of developing new‐onset diabetes. However, the underlying mechanism remains unclear. In this study, we administered rosuvastatin (10 mg/kg body weight) to male
Xue Bai, Xingzhen Long, Fang Song, Baolin Chen, Changcheng Sheng, Cailin Tang, Li Li, Jiaxing Zhang, Rui Zhang, Jiquan Zhang, Jiali Li   +10 more
doaj   +1 more source

Bioequivalence study of fixed-dose combination Losartan + amlodipine + rosuvastatin Sanofi in comparison with coadministered fixed- dose combination Lozap® AM and monocomponent drug Crestor® in healthy subjects

Фармакокинетика и Фармакодинамика, 2022
Introduction. The advantages of fixed-dose combination losartan + amlodipine + rosuvastatin compared to mono-drugs and two-component combinations are to increase the therapeutic efficacy, to reduce the cost of the product and to make the drug easier to ...
A. L. Khokhlov, D. Yu. Grebenkin, E. K. Faeva, V. I. Kazey, A. A. Khokhlov, A. E. Miroshnikov, O. V. Lebedeva   +6 more
doaj   +1 more source

NanoUPLC-QTOF-MS/MS Determination of Major Rosuvastatin Degradation Products Generated by Gamma Radiation in Aqueous Solution

Pharmaceuticals, 2021
Rosuvastatin, a member of the statin family of drugs, is used to regulate high cholesterol levels in the human body. Moreover, rosuvastatin and other statins demonstrate a protective role against free radical-induced oxidative stress.
Lucija Dončević, Ema Svetličić, Amela Hozić, Branka Mihaljević, Dorota Jarmużek, Ivana Tartaro Bujak, Donata Pluskota-Karwatka, Luka Ozdanovac, Iva Džeba, Mario Cindrić   +9 more
doaj   +1 more source

Rosuvastatin Improves Vaspin Serum Levels in Obese Patients with Acute Coronary Syndrome

Diseases, 2018
Adipose tissue-derived serine protease inhibitor (vaspin), which has endocrine and local roles in atherosclerosis growth, is also synthesized by adipose tissue; it was found that vaspin was negatively correlated with blood pressure in obese patients ...
Hayder M. Al-kuraishy, Ali I. Al-Gareeb, Ali K. Al-Buhadilly   +2 more
doaj   +1 more source

The influence of the intestinal microflora to the efficacy of Rosuvastatin

Lipids in Health and Disease, 2018
Background Intestinal microflora has been shown to play essential roles in the clinical therapies of metabolic diseases. The present study is aiming to investigate the potential roles and mechanisms of how intestinal microflora mediates lipid-reduction ...
Lijun Wang, Yang Wang, Hongwei Wang, Xue Zhou, Xianjing Wei, Zezhou Xie, Zhipeng Zhang, Keke Wang, Jianjun Mu   +8 more
doaj   +1 more source