Results 41 to 50 of about 31,394 (214)

Protective effect of Rosuvastatin on Azithromycin induced cardiotoxicity in a rat model

Life Science, 2021
Aims Azithromycin is widely used broad spectrum antibiotic recently used in treatment protocol of COVID-19 for its antiviral and immunomodulatory effects combined with Hydroxychloroquine or alone.
Basma S. Mansour, N. Salem, G. Kader, G. Abdel-Alrahman, O. Mahmoud   +4 more
semanticscholar   +1 more source

Rosuvastatin cocrystals: an attempt to modulate physicochemical parameters

Future Journal of Pharmaceutical Sciences, 2021
The meager physicochemical properties like low solubility and low dissolution rate of rosuvastatin calcium remain as an obstruction for formulation development.
Venkata Deepthi Vemuri, S. Lankalapalli
semanticscholar   +1 more source

Tranexamic acid and rosuvastatin in patients at risk of cardiovascular events after noncardiac surgery: a pilot of the POISE-3 randomized controlled trial

Pilot and Feasibility Studies, 2020
Background Surgical bleeding is associated with postoperative cardiovascular complications. The efficacy and safety of tranexamic acid (TXA) in noncardiac surgery are still uncertain. Statins may prevent perioperative cardiovascular complications.
Maura Marcucci, Emmanuelle Duceppe, Yannick Le Manach, Clive Kearon, John W. Eikelboom, Kayla Pohl, Jessica Vincent, Saeed Darvish-Kazem, Sadeesh K. Srinathan, John D. D. Neary, Joel L. Parlow, Andrea Kurz, Peter L. Gross, Marko Mrkobrada, Kumar Balasubramanian, Daniel I. Sessler, P. J. Devereaux   +16 more
doaj   +1 more source

Determination of a “Specific Population Who Could Benefit From Rosuvastatin”: A Secondary Analysis of a Randomized Controlled Trial to Uncover the Novel Value of Rosuvastatin for the Precise Treatment of ARDS

Frontiers in Medicine, 2020
Background: The high heterogeneity of acute respiratory distress syndrome (ARDS) contributes to paradoxical conclusions from previous investigations of rosuvastatin for ARDS.
Shi Zhang, Zhonghua Lu, Zongsheng Wu, Jianfeng Xie, Yi Yang, Haibo Qiu   +5 more
doaj   +1 more source

A randomized controlled trial of the short-term effect of rosuvastatin on the corrected QT interval

Scientific Reports
Rosuvastatin can block human ether-a-go-go related gene (hERG) currents and prolong the corrected QT (QTc) interval, but this effect has not been confirmed in the population.
Lijun Zhu, Wenjun Shen, Wanying Hu, Haiwang Guan, Yanwei Wang, Conglin Wang, Jing Lin, Li Chen, Qingjun Jiang   +8 more
doaj   +1 more source

Rosuvastatin alters the genetic composition of the human gut microbiome

Scientific Reports, 2020
The gut microbiome contributes to the variation of blood lipid levels, and secondary bile acids are associated with the effect of statins. Yet, our knowledge of how statins, one of our most common drug groups, affect the human microbiome is scarce.
M. Kummen, O. Solberg, Christopher Storm-Larsen, K. Holm, A. Ragnarsson, M. Trøseid, B. Vestad, R. Skårdal, A. Yndestad, T. Ueland, A. Svardal, R. Berge, I. Seljeflot, L. Gullestad, T. Karlsen, L. Aaberge, P. Aukrust, J. Hov   +17 more
semanticscholar   +1 more source

Photogenerated Oxetanes as a Gateway to Uphill Cyclopropanation

Angewandte Chemie International Edition, EarlyView.
An atom‐economical route to densely functionalized cyclopropanes from furans and photochemically activated aldehydes is enabled by a unique oxetane‐to‐cyclopropane rearrangement. These cyclopropanes can be used to access complex bioactive scaffolds and serve as a platform for asymmetric cyclopropane synthesis.
Tim Köglmeier, Thomas J. Tiefel, Oliver Reiser   +2 more
wiley   +1 more source

Multiply doses of FDC of rosuvastatin and ezetimibe versus rosuvastatin monotherapy in Chinese patients with hypercholesterolemia (ROSE-CH): multicenter, randomized-controlled trial

Lipids in Health and Disease
Objective Rosuvastatin plus ezetimibe improves the lipid-lowering effect through different mechanisms of action. This study intended to compare the efficacy and safety of the fixed-dose combination (FDC) of rosuvastatin/ezetimibe vs.
Xianyou Ji, Jinlan Xia, Hong Zhang, Changjie Ren, Guang Ma, Shenwen Fu, Jun Zhang, Ying Chen, Xuebin Han, Jianming Zhang, Zhengxu Fang, Bo Yang, Baisong Yang, Wenjun Huang, Gang Yin, Hong Qi, Hao Gong, Dongfang Wang, Liuyi Hao, Xiufeng Zhao, Zhaohui Pei, Peijian Wang, Xiaodong Li, Ling Lin, De Li, Zhi Li, Lin Zhang, Bo Yin, Ying Cheng, Zhiqing You, Jianlong Sheng, Jie Wu, Ling Chen, Zhongcai Fan, Wang Zhao, Shuiping Zhao   +35 more
doaj   +1 more source

Investigation of montelukast effect on rosuvastatin induced late puberty in rats

Journal of Human Reproductive Sciences, 2022
Background: Puberty is a critical process for the development of sexual organs and reproductive ability. It is triggered and regulated by the hormones.
Tamadir Hamid Wadi Aledani, Manal Nasser Al-Hayder, Suha Haitham Mohammed, Rawaa Salim Al-Mayyahi   +3 more
doaj   +1 more source

Pharmacokinetic profiling of imatinib in relation to CYP3A4 activity in leukaemia patients

British Journal of Clinical Pharmacology, EarlyView.
Aim Imatinib pharmacokinetics exhibit large interindividual variability because of differences in CYP3A4 activity—the main imatinib‐metabolizing enzyme. While therapeutic drug monitoring is effective, it requires steady‐state conditions and frequent sampling.
Anna Sofie Buhl Rasmussen, Mathilde Rønne Koch, Cecilie Utke Rank, Christen Lykkegaard Andersen, Allan Weimann, Maria Thastrup, Tianwu Yang, Trine Meldgaard Lund, Ib Jarle Christensen, Flemming Nielsen, Tore Bjerregaard Stage, Sara Bisgaard Jensen, Mette Klarskov Andersen, Kjeld Schmiegelow, Kim Dalhoff   +14 more
wiley   +1 more source