Results 51 to 60 of about 31,394 (214)

Current practice and guideline adherence in renal dose adjustment for patients with chronic kidney disease: A systematic review and meta‐analysis

British Journal of Clinical Pharmacology, EarlyView.
Aims To quantify prescribing adherence to renal dosing recommendations in adults with chronic kidney disease (CKD; Stage 3 and above) and to evaluate the clinical consequences of non‐adherence. Methods This systematic review and meta‐analysis was conducted in accordance with PRISMA 2020 guidelines and registered in PROSPERO (CRD42025620883).
Hager ElGeed, Ahmed Tehemar, Mohamed Gasimelseed, Ahmed Gharaibeh, Muhammad Abdul Hadi, Kazeem Yusuff, Amani Zidan, Ahmed Awaisu   +7 more
wiley   +1 more source

Rosuvastatin Ameliorates the Initiation and Progression of Lung Adenocarcinoma via Facilitating PLK1 Inhibition

Frontiers in Bioscience-Landmark
Background: Lung cancer remains a major global public health challenge, with lung adenocarcinoma being the most prevalent histologic subtype.
Jie Yin, Jianjie Zhu, Yinhua Gong, Wenting Wu, Xinyu Zhang, Chang Li, Yang Yang, Yili Chen, Jianjun Li, Lei Gu, Jian-an Huang, Zeyi Liu, Dan Shen, Yuanyuan Zeng   +13 more
doaj   +1 more source

Content of matrix metalloproteinases in the blood of hypertensive patients with a high cardiovascular risk receiving statin therapy

Кардиоваскулярная терапия и профилактика, 2022
Aim. To compare the effect of atorvastatin and rosuvastatin as part of complex therapy in patients with hypertension (HTN) with a high cardiovascular risk on the level of matrix metalloproteinases -1, -9 (MMP-1, MMP-9) and tissue inhibitors of ...
V. P. Mikhin, O. A. Osipova, V. V. Vorotyntseva, D. N. Perutsky, N. I. Golovina   +4 more
doaj   +1 more source

Mechanical Thrombus Aspiration for a Young STEMI Patient With Plaque Erosion: Time for a Stent‐Free Approach?

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT A 34‐year‐old man with no cardiovascular history presented with anterior ST‐elevation myocardial infarction and a large thrombotic occlusion of the mid left anterior descending artery. Following potent antithrombotic therapy and mechanical thrombus aspiration, angiography revealed vessel patency without residual significant stenosis, allowing ...
Domenico Simone Castiello, Francesco Greco, Antonio Curcio, Alberto Polimeni   +3 more
wiley   +1 more source

Stability Indicating Liquid Chromatographic Method for the Simultaneous Determination of Rosuvastatin and Ezetimibe from Pharmaceuticals and Biological Samples

Journal of the Turkish Chemical Society, Section A: Chemistry, 2020
Fixed dose combinations of ezetimibe and rosuvastatin are well known to provide significantly superior efficacy to rosuvastatin alone in lowering total cholesterol, and triglyceride levels.
Sevinç KURBANOĞLU, Ozgur ESİM, Cansel KOSE OZKAN, Ayhan SAVAŞER , Yalcin OZKAN, Bengi USLU , Sibel ÖZKAN   +6 more
doaj  

Clinical Characterization of Enzyme and Transporter Precipitants to Evaluate Drug–Drug Interactions for Orforglipron, a Small Molecule Glucagon‐Like Peptide‐1 Receptor Agonist

Clinical Pharmacology &Therapeutics, EarlyView.
Orforglipron is an orally administered, small‐molecule glucagon‐like peptide‐1 receptor agonist in clinical development for the treatment of type 2 diabetes and obesity. Orforglipron is a substrate of CYP3A4, organic anion transporting polypeptides (OATPs) 1B/1B3, and P‐glycoprotein (P‐gp); however, precipitants commonly used to define these mechanisms
Bridget L. Morse, David E. Coutant, Xiaosu Ma, Sohini Raha, Keerthan Aithal, Clare Nicoll, Luc R. A. Rougée, Shobha Bhattachar   +7 more
wiley   +1 more source

A pharmacokinetic drug–drug interaction study between rosuvastatin and emvododstat, a potent anti‐SARS‐CoV‐2 (COVID‐19) DHODH (dihydroorotate dehydrogenase) inhibitor

Pharmacology Research & Perspectives, 2023
A therapeutic agent that targets both viral replication and the hyper‐reactive immune response would offer a highly desirable treatment for severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2; COVID‐19) management.
Terri L. Morton, Oscar L. Laskin, Diksha Kaushik, Lucy Lee, Jiyuan Ma, Allan Kristensen, Kylie O'Keefe, Lee Golden, Matthew Klein, Ronald Kong   +9 more
doaj   +1 more source

Sustainable Iron Catalysis for Chemodivergent Oxidation of Lignin‐Based Vanillyl Alcohol: Selective Access to Vanillin and Vanillic Acid

European Journal of Organic Chemistry, EarlyView.
Green reaction media enable chemodivergent oxidation of vanillyl alcohol, selectively affording vanillin or its fully oxidized counterpart, vanillic acid. The use of an earth‐abundant, inexpensive, and nontoxic iron catalyst for the transformation of lignin‐derived alcohol to fine chemicals underscores the sustainability of the process. A low E‐factor (
Rasmiranjan Hota, Chinmaya Kumar Meher, Bidraha Bagh   +2 more
wiley   +1 more source

Therapeutic‐dose verapamil‐induced cardiogenic shock in an older patient: a case report

Journal of Pharmacy Practice and Research, EarlyView.
Abstract Background Calcium channel blocker (CCB) toxicity most commonly follows deliberate overdose. However, severe toxicity at therapeutic doses may occur in susceptible individuals. Severe CCB toxicity often presents with clinical features of bradycardia, hypotension, hyperglycaemia, and lactic acidosis.
Christopher Thuring, Maria Carey, Timothy Webber, Biswadev Mitra   +3 more
wiley   +1 more source

Rosuvastatin prevents proteinuria and renal inflammation in nitric oxide-deficient rats

Clinics, 2011
OBJECTIVE: The aim of the present study was to assess the effects of rosuvastatin on renal injury and inflammation in a model of nitric oxide deficiency.
Jose Marcos Girardi, Rogerio Estevan Farias, Ana Paula Ferreira, Nadia Rezende Barbosa Raposo   +3 more
doaj   +1 more source