Results 71 to 80 of about 2,634,553 (326)

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Assimilation and return of nutrient elements by plants in soil and impact of crop residues on soil fertility in short cotton rotations

Растениевъдни науки, 2015
To develop a highly efficient the short cycled rotations which provide conservation and improvement soil fertility, of Silt Loam Calcic Xerosol (FAO, 2003) of Tashkent region and the results of the investigations recommend and inculcate to agricultural ...
Abdulaly Iminov, Fazliddin Namazov, Bakhodir Khalikov   +2 more
doaj  

Agricultural Drone-Based Variable-Rate N Application for Regulating Wheat Protein Content

Drones
Implementing a variable-rate application (VRA) of fertilization based on real-time crop growth status reduces costs and enhances work efficiency. However, the technical challenges associated with obtaining accurate growth-distribution maps and applying ...
Senlin Guan, Yumi Shimazaki, Kimiyasu Takahashi, Hitoshi Kato, Koichiro Fukami, Shuichi Watanabe   +5 more
doaj   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Incremental and Transitive Discrete Rotations [PDF]

, 2006
A discrete rotation algorithm can be apprehended as a parametric application $f\_\alpha$ from $\ZZ[i]$ to $\ZZ[i]$, whose resulting permutation ``looks like'' the map induced by an Euclidean rotation.
A. Amir, B. Nouvel, B. Nouvel, B. Nouvel, K. Voss, R. Klette   +5 more
core   +4 more sources

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Total Knee Arthroplasty with an Oxidised Zirconium Femoral Component: A 5-Year Follow-up Study

Journal of Orthopaedic Surgery, 2014
Purpose. To report the early results of the Oxinium Genesis II prosthesis with an oxidised zirconium femoral component in 55 patients. Methods. 71 knees in 21 men and 34 women aged 32 to 75 (mean, 55) years were evaluated; 16 of the patients had ...
Derek H Park, Julian Leong, Stephen J Palmer   +2 more
doaj   +1 more source

Evaluating Gyrochronology on the Zero-Age-Main-Sequence: Rotation Periods in the Southern Open Cluster Blanco 1 from the KELT-South Survey

, 2013
We report periods for 33 members of Blanco 1 as measured from KELT-South light curves, the first reported rotation periods for this benchmark zero-age-main-sequence open cluster.
Cargile, P. A., James, D. J., Kuhn, R. B., Pepper, J., Siverd, R., Stassun, K. G.   +5 more
core   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Prevention of Knot Slippage with the Use of Cyanoacrylate Glue: A Mechanical Study

Journal of Orthopaedic Surgery, 2013
Purpose. To assess the effect of cyanoacrylate glue on knot slippage and strength in vitro . Methods. Ethibond 3/0 was tested using a tensile tester. A single drop of cyanoacrylate glue was applied to the knots. Seven knot configurations (10 samples each)
George H Smith, JE McEachan, A McLean, JS Huntley   +3 more
doaj   +1 more source