Results 151 to 160 of about 38,087 (260)

Resveratrol Ameliorates Allergic Rhinitis by Activating SIRT1 to Disrupt the Mitochondrial ROS‐Inflammation Vicious Cycle

Flavour and Fragrance Journal, Volume 41, Issue 5, Page 1187-1200, September 2026.
This study demonstrates that resveratrol alleviates allergic rhinitis by activating SIRT1, thereby disrupting the mitochondrial ROS‐inflammatory cycle, improving mitochondrial function, promoting anti‐inflammatory M2 macrophage polarisation, and reducing epithelial oxidative damage.
Xinyu Zhou, Yi Yue, Wenwen Qi, Wenqing Zhu, Xinran Liu, Rongcui Sui, Xuanchen Zhou   +6 more
wiley   +1 more source

Neurodegeneration at the crossroads: the gut-brain axis and blood-brain barrier in Parkinson's disease - a review. [PDF]

Front Pharmacol
Gamal NK, Fakhry R, Hatem Y, Rashed E, Marzouk R, Bukr AKM, Akawi N, George MY.   +7 more
europepmc   +1 more source

Cell Death in Neurodegenerative Diseases: Molecular Mechanisms and Therapeutic Targets

MedComm, Volume 7, Issue 9, September 2026.
Regulated cell death pathways, including apoptosis, necroptosis, pyroptosis, ferroptosis, and autophagy‐dependent cell death, interact with mitochondrial dysfunction, proteostasis failure, lysosomal stress, glial remodeling, and neuroinflammation across major neurodegenerative diseases.
Tianjiao Li, Qian Zhang, Yichen Wu, Ruixue Huang   +3 more
wiley   +1 more source

D-mannose alleviates rotenone-induced PD mouse model through microbiota-gut-brain axis. [PDF]

Sci Rep
Hong Y, Ge C, Jin J, Gao Y, Tang Y.
europepmc   +1 more source

Aged Mitochondrial DNA Is Associated With Aberrant Acute Exercise‐Induced Redox Responses in Human Skeletal Muscle

Aging Cell, Volume 25, Issue 9, September 2026.
Findings from this study suggest that aging is accompanied by altered skeletal muscle mitochondrial redox regulation and exercise responsiveness, with decreased mtDNA copy number, increased mtDNA mutation deletion frequency, and selective redox remodeling of key mitochondrial proteins representing potential contributors to these changes. ABSTRACT Redox
Bradley A. Ruple, Nicholas A. Carlini, Jason S. Kofoed, Helya Rostamkhani, Brady E. Hanson, Jesse C. Craig, Shelby C. Osburn, Allison M. Manuel, Paul A. Stewart, Jonathan Wanagat, Ryan M. Broxterman, Joel D. Trinity   +11 more
wiley   +1 more source

Chromatin accessibility and transcriptome in human neuronal model exposed to Parkinson's environmental toxins. [PDF]

Sci Data
Hong J, Huang J.
europepmc   +1 more source

Ferroptosis‐Based Peripheral Immune Dysregulation and Diagnostic Signatures in Parkinson's Disease: An RNA Transcriptomic and Single‐Cell Immune Sequencing Analysis

The FASEB Journal, Volume 40, Issue 15, 15 August 2026.
This study explored the crosstalk between ferroptosis‐related genes and peripheral immune alterations in Parkinson's disease. We constructed a gene signature and classified molecular subtypes, and further pinpointed key ferroptosis‐associated molecules in immune cells and neuronal cells.
Lei Cheng, Jing Zhang, Wen‐Ting Shi, Qing Ye, Chen Huang, Zhong‐Yan Zhou   +5 more
wiley   +1 more source

A humanized engineered heart tissue platform for cardiotoxicity assessment. [PDF]

Stem Cell Reports
Sun YH, Diloretto DA, Kao HKJ, Sirish P, Morisseau C, Sule R, Hsu MF, Smithers RL, Overton J, Timofeyev V, Merleev A, Grigorean G, Phinney BS, Maverakis EM, Gomes AV, Haj FG, Nolta JA, Chan JW, Hammock BD, Lieu DK, Chiamvimonvat N.   +20 more
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, Volume 16, Issue 8, Page 1563-1592, August 2026.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Sex-specific metabolic and microbial remodeling in a rotenone-induced rat model of Parkinson's disease following nicotine administration. [PDF]

Biol Sex Differ
Ni Z, Wang G, Li Q, Wu X, Song Z, Yu H, Yu P, Chen Y, Li L, Chen H, Hou H, Hu Q.   +11 more
europepmc   +1 more source