Results 61 to 70 of about 3,227,610 (295)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

THEORETICAL JUSTIFICATION OF EXPONENTIAL DISTRIBUTION LAW OF DISTANCES BETWEEN STOPS OF CITY PUBLIC TRANSPORT [PDF]

Avtomobilʹnyj Transport (Harʹkov), 2012
The paper presents the results of investigation of relation bitween the trip distance on stops location on the route between places of attraction. Theoretical justification of the use fulness of exponential distribution with the shift parameter for ...
Gorbachov, P., Makarychev, O. , Svichynskyi, S.   +2 more
doaj  

Optimal Detection of Faulty Traffic Sensors Used in Route Planning

, 2017
In a smart city, real-time traffic sensors may be deployed for various applications, such as route planning. Unfortunately, sensors are prone to failures, which result in erroneous traffic data.
Dubey, Abhishek, Ghafouri, Amin, Koutsoukos, Xenofon, Laszka, Aron   +3 more
core   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Drivers’ Response to In-Vehicle Route Guidance Information Systems: An Experiemnt with a Mock-Up Guidance System. [PDF]

, 1993
The paper reports an exploratory study, using an unusual technique to investigate drivers' response to in-vehicle route guidance information systems. Eighteen drivers were recruited, and asked to make a series of three trips in an unfamiliar area.
Bonsall, P.W., Gotts, N.M.
core  

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Qualitative Assessment of Urban Design Elements from the Old and New Urban Fabrics in Aïn-Beïda (Algeria) [PDF]

Urbanism. Arhitectura. Constructii
The effects of the physical environment on people's active behaviour have been a central topic over the last decade, particularly in urban design, public health, and transportation.
Ines Soltani, Rachid Hadef
doaj  

Pedestrian route choice: an empirical study [PDF]

, 1997
There has been relatively little work done on route choice for pedestrians. The present paper addresses this issue by using a sample survey of daily walks in a UK urban area.
Heydecker, BG, Verlander, NQ
core  

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source