Results 81 to 90 of about 3,227,610 (295)
FEBS Open Bio, EarlyView.We analyzed alterations of PAR metabolism‐related proteins in PARG inhibitor‐resistant HCT116RPDD cells. Although PARG levels remained unchanged, HCT116RPDD cells exhibited reduced PARP1 and ARH3 expression and elevated PAR levels. Interestingly, HCT116RPDD cells exhibited slightly elevated intracellular NAD+/NADH and ATP levels. Our findings suggest a
Kaede Tsuda, Yoko Ogino, Akira Sato
wiley +1 more source
Applications of polymers in intraocular drug delivery systems
Oman Journal of Ophthalmology, 2017 We are entering a new era of ophthalmic pharmacology where new drugs are rapidly being developed for the treatment of anterior and posterior segment of the eye disease.
Ali Mohammed Alhalafi
doaj +1 more source
FEBS Open Bio, EarlyView.Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn +4 more
wiley +1 more source
Geodesic survey and modernization of a route as the task of optimization
Geodesy and Cartography, 2014 Inwentaryzacja istniejącej tras y wymaga wyznaczenia krzywej aproksymującej w wyniku optymalizacji realizowanej metodą najmniejszych kwadratów (TLSM). Analiza funkcji celu LSM wykazała, że jest ona kwadratem odległości Mahalanobisa w przestrzeni poprawek.
Nowak Edward
doaj +1 more source
FEBS Open Bio, EarlyView.Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu +10 more
wiley +1 more source
FEBS Open Bio, EarlyView.This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel +4 more
wiley +1 more source
Electrification of Urban Transport. Basic Stages in Creating Electric Buses Fleet
Механика машин, механизмов и материалов, 2018 The paper is of an analytical nature and is devoted to the systematization of approaches that take place in the tasks of creating an urban fleet of electric buses.
Vladimir B. Algin
doaj
Transport, 2011 The article describes modelling a vehicle route to transport goods and discusses models for determining vehicle routes for a single depot and more vehicles. Above all, the paper defines a mathematical model for determining a vehicle route for more depots,
Jaroslav Kleprlík +2 more
doaj +1 more source
A simple proof for visibility paths in simple polygons
, 2020 The purpose of this note is to give a simple proof for a necessary and sufficient condition for visibility paths in simple polygons. A visibility path is a curve such that every point inside a simple polygon is visible from at least one point on the path.
Charkari, Nasrollah Moghaddam +1 more
core
Hellmann and Feynman theorem versus diffusion Monte Carlo experiment
, 2013 In a computer experiment the choice of suitable estimators to measure a physical quantity plays an important role. We propose a new direct route to determine estimators for observables which do not commute with the Hamiltonian. Our new route makes use of
Fantoni, Riccardo
core +1 more source