Results 11 to 20 of about 111,748 (238)
Estudo comparativo de procedimentos experimentais e computacionais para cálculo da lipofilia molecular [PDF]
Saúde & Tecnologia, 2011 Introdução – A lipofilia é uma das propriedades físico-químicas que mais influencia a capacidade de uma molécula se movimentar através de compartimentos biológicos.
Gonçalo Clemente
doaj +4 more sources
Development and Validation of a Robust RP-HPLC Method for Quantifying Dasatinib in Self-Microemulsifying Drug Delivery Systems. [PDF]
Int J Anal ChemDasatinib, a therapy for chronic myeloid leukemia, suffers from poor bioavailability. Self-microemulsifying drug delivery systems (SMEDDSs) are used to improve its dissolution.
Kokare NV +12 more
europepmc +2 more sources
Journal of Chromatography Open, 2022 Most commonly used analytical technique for determination of active pharmaceutical ingredients and their impurities in quality control throughout all phases of drug research, development and manufacture is definitely reversed-phase high performance ...
Nevena Djajić +7 more
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In Silico and RP HPLC Studies of Biologically Active 1,3,4-Thiadiazol-2-yl)-benzene-1,3-diols. [PDF]
MoleculesBiologically active compounds from the 1,3,4-thiadiazol-2-yl)-benzene-1,3-diols group described earlier have been studied. Various approaches were used to determine their lipophilicity and predict pharmacokinetic properties.
Studziński M +5 more
europepmc +2 more sources
Exploration of Targeted Anti-tumor Therapy, 2021 Aim: Direct analytical comparison of two major drug-linkers in the antibody-drug conjugate (ADC) field was conducted. Methods: Four different analytical methods [AlogP calculation, reverse phase (RP) high-performance liquid chromatography (HPLC; RP ...
Tomohiro Fujii +5 more
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Design of Experiment Centered Multivariate Optimization Strategy for RP-HPLC Method to Quantitate Retapamulin in Topical Cream and Microemulsion [PDF]
Pharmaceutical Sciences, 2021 Background: Retapamulin is the first pleuromutilin antibacterial approved for the treatment of impetigo. The objective of the current research was to utilize the design of experiments approach for development and optimization of robust RP-HPLC method for
Rashmin Bharat Patel +2 more
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Molecules, 2022 The routine techniques currently applied for the determination of nicotine and its major metabolites, cotinine, and trans-3′-hydroxycotinine, in biological fluids, include spectrophotometric, immunoassays, and chromatographic techniques.
Jacek Baj +7 more
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Development and Validation of RP-HPLC Method for the Determination of Dexrabeprazole Sodium
Sakarya Üniversitesi Fen Bilimleri Enstitüsü Dergisi, 2021 A rapid and simple liquid chromatographic method was developed for the quantitative determination of dexrabeprazole sodium in the tablet dosage form. The reverse-phase chromatographic analysis was carried out by using a C-18 column.
Semra Yılmazer Keskin +2 more
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Determination of the lipophilicity of 2'-hydroxychalcones by RP HPLC method [PDF]
Hemijska Industrija, 2016 Lipophilicity of twelve synthesized chalcones, whose ring B is a ortho, meta or para monosubstituted with alkyl, oxyalkyl groups or halogens was determined by reverse phase liquid chromatography, using octadecyl-functionalized (RP-18) silica gel
Bašić Jasmina V. +4 more
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Phosphorylated calix[4,8]arenes improve the RP HPLC separation of benzene derivatives
Журнал органічної та фармацевтичної хімії, 2020 Aim. To study the effect of 5,11,17,23-tetrakis(diisopropoxyphosphonyl)-25,26,27,28-tetrapropoxycalix[4]arene and oсtаkis(diethoxyphosphoryloxy)-tert-butylcalix[8]аrene additives to the MeCN – H2O mobile phase (86:14) on the selectivity of the separation
Olga I. Kalchenko +2 more
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