Results 251 to 260 of about 67,204 (291)

Development of a high‐throughput dual‐stream liquid chromatography–tandem mass spectrometry method to screen for inhibitors of glutamate carboxypeptidase II

Rapid Communications in Mass Spectrometry, EarlyView.
Rationale Glutamate carboxypeptidase II (GCPII) catalyzes the hydrolysis of N‐acetylaspartylglutamate (NAAG) to yield glutamate (Glu) and N‐acetylaspartate (NAA). Inhibition of GCPII has been shown to remediate the neurotoxicity of excess Glu in a variety of cell and animal disease models.
Nate Hoxie, Yixuan Qiu, Stephen C. Kales, Rick Schneider, Xin Hu, Anu Dalal, Stephanie L. Ford‐Scheimer, Robyn Wiseman, Takashi Tsukamoto, Huijun Wei, Barbara S. Slusher, John S. Janiszewski, Matthew D. Hall   +12 more
wiley   +1 more source

Greener and whiter analytical method development and validation for determining the presence of zolpidem tartrate infused in apple juice using RP-HPLC via magnetic solid-phase extraction followed by LC-MS confirmatory analysis. [PDF]

RSC Adv
Sundara Moorthy R, Swetha G, Rondla R, Hu A, Vallakeerthi N, Reddy PM.   +5 more
europepmc   +1 more source

Polymeric Giant Unilamellar Vesicles Support Longevity of Native Nuclei in Protocells

Small Science, EarlyView.
Native nuclei are isolated and incorporated into polymeric giant unilamellar vesicles (pGUVs) using microfluidics. Nucleated pGUVs retain nuclear integrity and function, providing a new platform to study the import process of peptide‐based multicompartment micelles via nuclear localization signals. This bottom‐up chimeric system lays the groundwork for
Lukas Heuberger, Arianna Balestri, Shabnam Tarvirdipour, Larisa E. Kapinos, Roderick Y. H. Lim, Emanuel Lörtscher, Cora‐Ann Schoenenberger, Cornelia G. Palivan   +7 more
wiley   +1 more source

Identification of Senomorphic miRNAs in Embryonic Progenitor and Adult Stem Cell‐Derived Extracellular Vesicles

Aging Cell, EarlyView.
A senomorphic miRNA cocktail (E5), consisting of miR‐181a‐5p, miR‐92a‐3p, miR‐21‐5p, and miR‐186‐5p, was identified from a pool of miRNAs enriched in extracellular vesicles (EVs) derived from multiple functional human stem cell types. E5 reduces senescence and SASP markers both in cell culture and in aged mice.
Tianpeng Zhang, Allancer D. C. Nunes, Jieun Lee, Dana Larocca, Giovanni Camussi, Sai Kiang Lim, Vicky U. Bascones, Luise Angelini, Ryan D. O'Kelly, Xiao Dong, Laura J. Niedernhofer, Paul D. Robbins   +11 more
wiley   +1 more source

An antisense oligonucleotide targeting the heat‐shock protein HSPB5 as an innovative therapeutic approach in pulmonary fibrosis

British Journal of Pharmacology, EarlyView.
Background and Purpose Idiopathic pulmonary fibrosis (IPF) is a fatal disease characterized by fibroblast activation and abnormal accumulation of extracellular matrix in the lungs. We previously demonstrated the importance of the heat shock protein αB‐crystallin (HSPB5) in TGF‐β1 profibrotic signalling, which suggests that HSPB5 could be a new ...
Pierre‐Marie Boutanquoi, Lenny Pommerolle, Lucile Dondaine, Julie Tanguy, Pierre‐Simon Bellaye, Léo Biziorek, Marine Gautier‐Isola, Bernard Mari, Denis Masnikov, Palma Rocchi, Pascal Finetti, Patricia Korczak, Brune Vialet, Philippe Barthelemy, Carmen Garrido, Philippe Bonniaud, Olivier Burgy, Françoise Goirand   +17 more
wiley   +1 more source

Chemical profiling and characterisation of anthraquinone‐based polyphenols as biocolourants from Cortinarius semisanguineus

Coloration Technology, EarlyView.
Abstract Anthraquinone dyes are known for their significant colour (brightness of shade in the red, blue and green areas) and light fastness properties compared with other synthetic dyes (such as azo‐based dyes). However, challenging multi‐step synthesis of anthraquinones and limited access to fewer substituents result in insufficient reactivity ...
Arvind Negi, Peppi Toukola, Riikka Räisänen   +2 more
wiley   +1 more source

ENX‐101, a GABAA receptor α2,3,5‐selective positive allosteric modulator, displays antiseizure effects in rodent seizure and epilepsy models

Epilepsia, EarlyView.
Abstract Objective γ‐Aminobutyric acid type A (GABAA) receptor positive allosteric modulators (PAMs) that lack α‐subunit selectivity, including benzodiazepines such as diazepam, exhibit antiseizure actions in animal models and in humans. ENX‐101 is a deuterated analog of the ⍺2,3,5‐selective GABAA receptor PAM L‐838,417.
Jordi Serrats, Krishna C. Vadodaria, William Brubaker, Melissa Barker‐Haliski, H. Steve White, Alexis Evrard, Corinne Roucard, Eve Taylor, Kimberly E. Vanover, Stephen Cunningham, Vikram Sudarsan, Michael A. Rogawski   +11 more
wiley   +1 more source

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RP-HPLC Binding Domains of Proteins

Analytical Chemistry, 1998
Procedures have been developed to identify the chromatographic binding domains of horse heart cytochrome c (Cyt c) and bovine growth hormone (bGH) during their interaction with reversed-phase sorbent materials. The procedure involves adsorption of the protein solute to the chromatographic sorbent, followed by proteolytic cleavage.
Aguilar, Marie-Isabel, Clayton, Daniel J., Holt, Phillip, Kronina, Veronica, Boysen, Reinhard I., Purcell, Anthony W., Hearn, Milton T. W.   +6 more
openaire   +4 more sources