Results 251 to 260 of about 561,328 (285)

Optimized Lanthanide(III) Tags for Rapid and Efficient Protein Labeling in Electron Paramagnetic Resonance and Luminescence Applications

ChemistryEurope, Volume 4, Issue 1, January 2026.
Three novel Ln(III) complexes for efficient, site‐specific cysteine labeling under mild aqueous conditions are reported. A kinetic study reveals how subtle changes to the reactive pendant arm tune tagging rates, with Tb.QuNO achieving >95% cysteine labeling in 10 min.
Lydia Topping, Elena M. Mocanu, S. Ronan Fisher, Robert I. Hunter, Yasmin Ben‐Ishay, Daniella Goldfarb, Graham M. Smith, Janet E. Lovett, Stephen J. Butler   +8 more
wiley   +1 more source

Proximity‐Induced Ligation of Noncomplementary Oligonucleotides Triggered by Charge‐Transfer Interactions

ChemistryEurope, Volume 4, Issue 1, January 2026.
Charge‐transfer assisted ligation (CTAL) enables ultrafast CuAAC and SPAAC conjugation of a tetra‐DiAlkoxyNaphthalene (DAN4)‐azide and a noncomplementary tetraNaphthaleneDiImide (NDI4)‐alkyne oligonucleotide under dilute conditions, and the reaction can be carried out tracelessly by subsequently removing the tags.
Laura Nicollet, Kévan Pérez de Carvasal, Nessrine Graidia, François Morvan, Michael Smietana   +4 more
wiley   +1 more source

Development and Validation of a Robust RP-HPLC Method for the Simultaneous Analysis of Exemestane and Thymoquinone and Its Application to Lipid-Based Nanoformulations. [PDF]

ACS Omega
Gupta P, Sharma S, Gupta A, Kawish SM, Iqbal M, Rahman S, Aqil M, Kohli K, Sultana Y.   +8 more
europepmc   +1 more source

Allosteric Inhibitors of SARS‐CoV‐2 RNA‐Dependent RNA Polymerase Based on N,N′‐Diphenylurea

ChemMedChem, Volume 21, Issue 1, January 2026.
Inhibitors of SARS‐CoV‐2 RdRp activity based on N,N′‐diphenylurea scaffold have been identified. Several compounds exhibit residual activity (RA) below 50% in an enzymatic assay (at 10 µM concentration) and improved aqueous solubility compared to the previously reported series of inhibitors.
Artem Chayka, Matěj Danda, Alžběta Dostálková, Vojtěch Spiwok, Lamija Zijadic, Anna Klimešová, Marina Kapisheva, Michala Zgarbová, Jan Weber, Tomáš Ruml, Michaela Rumlová, Zlatko Janeba   +11 more
wiley   +1 more source

Simultaneous quantification of 4-hydroxytamoxifen and hesperidin in liposomal formulations: Development and validation of a RP-HPLC method. [PDF]

Heliyon
Lobo CL, M M, Shetty A, Shetty A, S A, K P, Dubey A.   +6 more
europepmc   +1 more source

Small‐Molecule Sarco/Endoplasmic Reticulum Ca2+‐ATPase Activators Reverse Methylglyoxal‐Induced Inhibition through Nonantioxidant Mechanisms

ChemMedChem, Volume 21, Issue 1, January 2026.
Endoplasmic reticulum (ER) Ca2+ dysregulation drives β‐cell dysfunction under diabetic stressors like methylglyoxal, which inhibits the sarco/endoplasmic reticulum Ca2+‐ATPase (SERCA) pump through oxidative modifications. We show that synthetic SERCA activators restore pump activity after methylglyoxal‐induced damage.
Carlos Cruz‐Cortés, Silvia Micháliková, Petronela Rezbáriková, L. Michel Espinoza‐Fonseca, Jana Viskupičová   +4 more
wiley   +1 more source

Unveiling New Arsenic Compounds in Plants via Tailored 2D-RP-HPLC Separation with ICP and ESI MS Detection. [PDF]

Molecules
Izdebska A, Budzyńska S, Bierla K.
europepmc   +1 more source

Customizing Native Chemical Ligation: A Case Study on Histone Variant H2A.B from Toolbox to Target

Chemistry–Methods, Volume 6, Issue 1, January 2026.
The core histone protein variant H2A.B, chosen as the target protein, is involved in many transcriptional processes regulated by its post‐translational modifications. Herein, the native chemical toolbox is harnessed to demonstrate the successful synthesis and semi‐synthesis of site‐specifically modified H2A.B variants via different strategies.
Tobias Gökler, Medine Soydan, Lydia Jane Barber, Garence Ferraton, Anne Claire Conibear   +4 more
wiley   +1 more source

Ryanodine‐1‐Calstabin Complex Stabilizers in Antidoping Research: Synthesis, Metabolism, and Characterization

ChemPlusChem, Volume 91, Issue 1, January 2026.
RYR‐stabilizers such as S107, JTV‐519, ARM 036, and ARM 210 are emerging doping‐relevant compounds due to their performance‐enhancing effects on leaky skeletal muscle Ca2+ channels. To support proactive antidoping efforts, all four compounds were synthesized and their in vitro metabolism was systematically investigated.
Tristan Möller, Thomas Piper, Mario Thevis   +2 more
wiley   +1 more source

RP-HPLC-CAD method for the rapid analysis of lipids used in lipid nanoparticles derived from dual centrifugation. [PDF]

Int J Pharm X
Bender V, Fuchs L, Süss R.
europepmc   +1 more source