Results 231 to 240 of about 97,740 (305)

Quality-by-Design-Driven RP-HPLC Method Development and Validation for Impurity Analysis of Elexacaftor, a Cystic Fibrosis Drug, with LC-MS/MS-Based Degradant Identification. [PDF]

ACS Omega
Raghupathi JK, Vemuri DK, Ali SM, Polisetti VK, Gundla R, Kowtharapu LP, Ramachandran D, Katari NK.   +7 more
europepmc   +1 more source

Flunaza assay by RP-HPLC method

, 2002
Jančić, Biljana, Malenović, Anđelija, Medenica, Mirjana   +2 more
openaire   +1 more source

Vesicular glutamate transporter VGLUT2 expression emerges in substantia nigra dopamine neurons in mouse models of parkinsonism in the absence of neurodegeneration

British Journal of Pharmacology, Volume 183, Issue 9, Page 2123-2138, May 2026.
Abstract Background and Purpose Subsets of midbrain dopamine (DA) neurons express the vesicular glutamate transporter VGLUT2 and can release the excitatory neurotransmitter glutamate. VGLUT2+ DA neurons of the substantia nigra pars compacta (SNc) were shown to be more resistant to neurodegeneration in animal models of Parkinson's disease (PD ...
Sivakumar Srinivasan, Christian Pifl, Thomas Steinkellner   +2 more
wiley   +1 more source

Implementation of the QbD Approach to the Analytical Method Development and Validation for the Estimation of the Treprostinil Injection Dosage Form by RP-HPLC. [PDF]

ACS Omega
Alluri NR, Bandlamudi MR, Kuppusamy S, Morais SR.   +3 more
europepmc   +1 more source

Polycationic Peptides That Bind T‐Box Riboswitch Antiterminator RNA and Inhibit Riboswitch Function

Chemical Biology &Drug Design, Volume 107, Issue 5, May 2026.
Polycationic decapeptides inhibit T‐box riboswitch tRNA‐induced transcription readthrough. ABSTRACT Resistance to antibiotic treatments continues to be a significant health challenge and necessitates investigating novel antibacterial targets including noncoding regulatory RNA.
Emily Fairchild, Danushika Herath, Sebastian Lux, Sophie R. Harvey, Deborah Amesaki, Destini McCartney, Monique Richter, Ralf Hoffmann, Jennifer V. Hines   +8 more
wiley   +1 more source

Technical note: optimizing and validating an RP-HPLC method to determine lactoferrin in porcine colostrum and milk. [PDF]

J Anim Sci
Metzger K, Gimsa U, Otten W.
europepmc   +1 more source

Modeling Synaptic Maturation From Growth Cone to Synapse in Human Organoids

Journal of Neurochemistry, Volume 170, Issue 5, May 2026.
Synapses are implicated in several neurological disorders and psychiatric diseases. The emergence and wide use of neural organoids provide a new opportunity to study human synapses in healthy and disease settings. Therefore, we developed a simple method for the enrichment of synaptosomes and growth cone particles from forebrain organoids. The method is
Marie S. Øhlenschlæger, Lucrezia Criscuolo, Pia Jensen, Daniel J. Lloyd‐Davies Sánchez, Magdalena Sutcliffe, Santosh Bhosale, Helle Bogetofte, Muhammad Tahir, Lene A. Jakobsen, Maria Pihl, Jonathan Brewer, Veit Schwämmle, Frantz R. Poulsen, Kristine Freude, Madeline A. Lancaster, Phillip J. Robinson, Martin R. Larsen   +16 more
wiley   +1 more source

Eco-friendly RP-HPLC method for simultaneous determination of water-soluble and fat-soluble vitamins in nano-formula and pharmaceutical dosage forms. [PDF]

BMC Chem
Salah El-Din SH, Mahmoud AM, Morsi A.
europepmc   +1 more source

In Vitro Metabolism and Analytical Characterization of SLU‐PP‐332 and SLU‐PP‐915: Novel Pan‐ERR Agonists With Doping Potential

Rapid Communications in Mass Spectrometry, Volume 40, Issue 8, 30 April 2026.
ABSTRACT Rationale Estrogen‐related receptor (ERR) agonists such as the drug candidates SLU‐PP‐332 and SLU‐PP‐915 are currently being investigated as exercise mimetics, given their ability to trigger human physiological processes similar to those initiated by actual physical activity.
Tristan Möller, Oliver Krug, Mario Thevis   +2 more
wiley   +1 more source

Identification of Degradation Products and a Stability-Indicating RP-HPLC Method for the Determination of Belzutifan in Pharmaceutical Dosage Forms.

J Pharm Bioallied Sci
Babu BS, Dutta K, Mondal S.
europepmc   +1 more source