Results 51 to 60 of about 67,204 (291)
CROMATOGRAFIA POR INTERAÇÕES HIDROFILICAS (HILIC): ESTADO DA ARTE E APLICAÇÕES
Química Nova, 2016 Hydrophilic interaction liquid chromatography (HILIC) has been gaining increased attention for its effective separation of highly polar compounds, which include carbohydrates, amino acids, pharmaceutical compounds, proteins, glycoproteins, nucleosides ...
Carla Grazieli Azevedo da Silva +2 more
doaj +1 more source
Opportunities in Therapeutic mRNA Stabilization: Sequence, Structure, Adjuvants and Vectors
Advanced Therapeutics, EarlyView.Current mRNA lipid nanoparticles rely on cold storage, which increases the cost and reduces access to the vaccines. As mRNA expands to other clinical opportunities, better methods to stabilize the medicines during shipping, storage, and delivery are needed.
Joshua A. Choe +4 more
wiley +1 more source
Advanced Science, EarlyView.Tirzepatide, a dual GIP/GLP‐1 receptor agonist for diabetes, suppresses colorectal cancer growth by targeting glucose metabolism. It inhibits cancer cell proliferation, promotes apoptosis, and induces tumor regression. It reduces glucose uptake and destabilizes HIF‐1α for degradation to downregulate PFKFB3/PFK‐1 enzymes, thus contributing to the ...
Yikai Zhang +11 more
wiley +1 more source
Prodrugs of the Archetypal Dynamin Inhibitor Bis‐T‐22
ChemMedChem, Volume 17, Issue 24, December 16, 2022., 2022 The Bis‐T series of compounds comprise some of the most potent inhibitors of dynamin GTPase activity yet reported, such as Bis‐T‐22 (2). The catechol moieties are believed to limit cell permeability, rendering these compounds largely inactive in cells.
Luke R. Odell +6 more
wiley +1 more source
Partial Characterization of Venom from the Colombian Spider Phoneutria Boliviensis (Aranae:Ctenidae)
Toxins, 2015 We report on the first studies on the characterization of venom from Phoneutria boliviensis (Aranae:Ctenidae) (F. O. Pickard-Cambridge, 1897), done with Colombian species.
Sebastian Estrada-Gomez +3 more
doaj +1 more source
RP- HPLC Estimation of Ceftriaxone Sodium in Pharmaceuticals [PDF]
Egyptian Journal of Chemistry, 2021 Abstract The idea of this work is to determine of Ceftriaxone sodium (CFT) through the development and verification of a accurate and rapid isocratic of RP-HPLC method using a C18 as stationary phase column. The mobile phase was described as a mixture of 80:20 Buffer:methanol.
openaire +2 more sources
Advanced Science, EarlyView.Meisoindigo targets PKMYT1 for degradation by acting as a molecular glue that enhances PKMYT1‐TRIM25 interaction, leading to K48‐linked ubiquitination and subsequent proteasomal degradation, thereby exerting therapeutic effects in chronic myeloid leukemia.
Zhao‐Xin Zhang +10 more
wiley +1 more source
ChemMedChem, Volume 17, Issue 23, December 5, 2022., 2022 The adipokine chemerin and the short peptide agonist chemerin‐9 activate two GPCRs: CMKLR1 and GPR1. Here, we established a nanoluciferase based binding assay to analyze differences in ligand binding. For GPR1, both ligands show high affinity and comparable binding.
Anne Sophie Czerniak +3 more
wiley +1 more source
Improved Method for Reliable HMW-GS Identification by RP-HPLC and SDS-PAGE in Common Wheat Cultivars
Molecules, 2017 The accurate identification of alleles for high-molecular weight glutenins (HMW-GS) is critical for wheat breeding programs targeting end-use quality. RP-HPLC methods were optimized for separation of HMW-GS, resulting in enhanced resolution of 1By and ...
You-Ran Jang +5 more
doaj +1 more source
A simple, sensitive and rapid isocratic reversed-phase high-performance liquid chromatography method for determination and stability study of curcumin in pharmaceutical samples [PDF]
Avicenna Journal of Phytomedicine, 2017 Objective: This study was designed to develop and validate a new reversed-phase high-performance liquid chromatography (RP-HPLC) method based on Q2 (R1) International Conference on Harmonization (ICH) guideline for determination of curcumin in ...
Farjad Amanolahi +4 more
doaj +1 more source