Results 71 to 80 of about 59,227 (260)
The chromatographic study of complexation of functionalized calix[4,8]arenes with aromatic aldehydes
Журнал органічної та фармацевтичної хімії, 2019 Aim. To study the Host-Guest complexation of octakis(diphenoxyphosphoryloxy)-tetramethylcalix[4]resorcinarene (PRA), 5,17-bis(N-tolyl-iminomethyl)-25,27-dipropoxycalix[4]arene (IC4A), 5,11,17,23-tetrakis(diisopropoxyphosphonyl)-25,26,27,28-tetra ...
O. I. Kalchenko +2 more
doaj +1 more source
Chemistry – A European Journal, EarlyView.Favipiravir (T‐705) and the non‐fluorinated counterpart (T‐1106) are antiviral agents that inhibit the RNA‐dependent RNA polymerase (RdRp) of various RNA viruses. The antiviral efficacy of nucleoside analogues is strongly dependent on their intracellular activation by cellular kinases to produce their corresponding triphosphate metabolites (T‐705‐RTP ...
Chris Meier +7 more
wiley +1 more source
Chemistry – A European Journal, EarlyView.A newly synthesized bifunctional azide—diazonium linker allows robust one‐step introduction of azido groups to single‐wall carbon nanotubes. Versatility of the azido groups as reactive handles is demonstrated by further derivatization with 6‐carboxyfluorescein and oligonucleotides.
Razieh Moosavi +6 more
wiley +1 more source
Fluorogenic Sydnones for Bioorthogonal Labeling of DNA
Chemistry – A European Journal, EarlyView.Conjugates of sydnones with cyanine‐styryl dyes combine bioorthogonal reactivity with fluorogenicity. The reactivity with bicyclo[6.1.0]non‐4‐yne (BCN)‐modified DNA showed second‐order rate constants of up to k2 = 2,300 M−1s−1 and fluorescence turn‐on by one magnitude of order.
Kerstin Müller +1 more
wiley +1 more source
Control of Gemcitabine Activity With Blue and Red Light
Chemistry – A European Journal, EarlyView.Treating cancer with chemotherapy is generally associated with many side effects, which can be addressed by selectively releasing the desired drugs with visible light. Sixteen new blue light‐activatable cytostatics were introduced, with the gemcitabine derivative exhibiting ideal properties.
Nils F. Kersten +6 more
wiley +1 more source
Asian Pacific Journal of Tropical Biomedicine, 2017 Objective: To investigate L-3, 4-dihydroxyphenylalanine (l-dopa, anti-Parkinson drug), anti-inflammatory activity, proximate nutritional composition and antioxidant potential of Mucuna macrocarpa (M. macrocarpa) beans.
Chetan Aware +5 more
doaj +1 more source
Rapid Access to Photoswitchable RNA Binders: Fluorination Enhances Protein Rescue by Exon Inclusion
Chemistry – A European Journal, EarlyView.An adaptable approach, many light‐switchable RNA binders. We report a versatile strategy for rapidly synthesizing photoswitchable RNA binders. The ligands can target SMN2 pre‐mRNA, restoring the levels of the corresponding protein by exon‐inclusion rescue.
Lei Zhang +10 more
wiley +1 more source
Discover ChemistryReverse-phase high-performance liquid chromatography (RP-HPLC) has continued to remain one of the most extensively employed analytical techniques in pharmaceutical analysis, with its high robustness, accuracy, and applicability.
Sushma Madhavaram, Judy Jays
doaj +1 more source
Molecules, 2018 The greening of analytical methods has gained increasing interest in the field of pharmaceutical analysis to reduce environmental impacts and improve the health safety of analysts.
Moussa Yabré +3 more
doaj +1 more source
Chemistry – A European Journal, EarlyView.A double‐headed bis‐guanine (G) nucleotide (GG) was evaluated as a noncanonical building block in G‐quadruplexes (G4s). Biophysical and computational analyses reveal that GG can directly participate in G‐tetrads and strongly stabilize G4s in a position‐ and topology‐dependent manner. These findings establish design rules for using GG to engineer highly
Krista Urup +5 more
wiley +1 more source