Results 81 to 90 of about 59,105 (258)

Late‐Stage Modification of Halotryptophan‐Containing Peptides Via Negishi Cross‐Coupling

Chemistry – A European Journal, EarlyView.
Negishi cross‐coupling provides access to the late‐stage functionalization of bromotryptophan‐containing peptides under comparatively mild conditions and is applicable to a range of peptide substrates in the investigated model systems. The examined alkyl iodides and variation of N‐terminal residues demonstrate the feasibility of the transformation in a
Laura Cerveson, Marcel‐Jannik Heldt, Norbert Sewald   +2 more
wiley   +1 more source

Membrane‐Permeable Nucleoside T‐1106 Diphosphate and Triphosphate Analogues as Antiviral Pronucleotides

Chemistry – A European Journal, EarlyView.
Favipiravir (T‐705) and the non‐fluorinated counterpart (T‐1106) are antiviral agents that inhibit the RNA‐dependent RNA polymerase (RdRp) of various RNA viruses. The antiviral efficacy of nucleoside analogues is strongly dependent on their intracellular activation by cellular kinases to produce their corresponding triphosphate metabolites (T‐705‐RTP ...
Chris Meier, Duan Li, Leentje Persoons, Graciela Andrei, Robert Snoeck, Dominique Schols, Lieve Naesens, Xiao Jia   +7 more
wiley   +1 more source

Successive Azide and DNA Functionalization for Reversible and Controlled Association of Single‐Wall Carbon Nanotubes

Chemistry – A European Journal, EarlyView.
A newly synthesized bifunctional azide—diazonium linker allows robust one‐step introduction of azido groups to single‐wall carbon nanotubes. Versatility of the azido groups as reactive handles is demonstrated by further derivatization with 6‐carboxyfluorescein and oligonucleotides.
Razieh Moosavi, Tharun K. Kotammagari, Pia Damlin, Mikko Salomäki, Mika Lastusaari, Han Li, Tuomas Lönnberg   +6 more
wiley   +1 more source

Evaluation of l-dopa, proximate composition with in vitro anti-inflammatory and antioxidant activity of Mucuna macrocarpa beans: A future drug for Parkinson treatment

Asian Pacific Journal of Tropical Biomedicine, 2017
Objective: To investigate L-3, 4-dihydroxyphenylalanine (l-dopa, anti-Parkinson drug), anti-inflammatory activity, proximate nutritional composition and antioxidant potential of Mucuna macrocarpa (M. macrocarpa) beans.
Chetan Aware, Ravishankar Patil, Swaroopsingh Gaikwad, Shrirang Yadav, Vishwas Bapat, Jyoti Jadhav   +5 more
doaj   +1 more source

Fluorogenic Sydnones for Bioorthogonal Labeling of DNA

Chemistry – A European Journal, EarlyView.
Conjugates of sydnones with cyanine‐styryl dyes combine bioorthogonal reactivity with fluorogenicity. The reactivity with bicyclo[6.1.0]non‐4‐yne (BCN)‐modified DNA showed second‐order rate constants of up to k2 = 2,300 M−1s−1 and fluorescence turn‐on by one magnitude of order.
Kerstin Müller, Hans‐Achim Wagenknecht   +1 more
wiley   +1 more source

Greening Reversed-Phase Liquid Chromatography Methods Using Alternative Solvents for Pharmaceutical Analysis

Molecules, 2018
The greening of analytical methods has gained increasing interest in the field of pharmaceutical analysis to reduce environmental impacts and improve the health safety of analysts.
Moussa Yabré, Ludivine Ferey, Issa Touridomon Somé, Karen Gaudin   +3 more
doaj   +1 more source

Determination of THC and THC‐COOH in Dried Capillary Blood Spots and Comparison to Venous Blood of Recreational Cannabis Consumers in a Pilot Study

Drug Testing and Analysis, EarlyView.
A new extraction method was developed and validated for the extraction of THC and THC‐COOH from capillary blood samples collected as dried blood spots. The extracts were analysed using HPLC–MS/MS resulting in high extraction efficiencies for both THC and THC‐COOH.
Matthias Bantle, Willi Schirmer, Joel Bruegger, Thomas Wüthrich, Andreas Längin, Lena Zwicker, Reto Auer, Wolfgang Weinmann   +7 more
wiley   +1 more source

N-linked oligosaccharides obtained from glycoproteins of the lichens Sticta tomentosa and Sticta damaecornis

Eclética Química, 2018
The lichens Sticta tomentosa and Sticta damaecornis were extracted to obtain glycoproteins. The extracts were fractionated with 30-80% saturation (NH4)2SO4. The fractions were reduced, alkylated and after dialysis the material were digested with trypsin.
Patrícia Fidelis de Oliveira, Flávia Doná, Marcelo Marcelli, Marilsa Cardoso, Maria de Lourdes Corradi da Silva   +4 more
doaj   +1 more source

Analysis of Dapsone by RP-HPLC

International Journal For Multidisciplinary Research
A Simple,Precise and accurate RP-HPLC method was developed and validated for the analysis of Dapsone in ...
openaire   +1 more source

Lattice‐Strained Cu2O‐Ni/NiO Heterostructure Enables Selective Electrocatalytic C–C Coupling of Alcohols to Cinnamaldehyde in Aqueous Medium

ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
This study achieved the selective oxidation C–C coupling of PhCH2OH with EtOH to form cinnamaldehyde (CAL) on a designed Cu2O‐Ni/NiO heterojunction catalyst. By employing a salt precipitation strategy to balance the pH and cation concentration, an 86% conversion rate of PhCH2OH and a 67% high selectivity for CAL were realized.
Tian Cheng, Kaizhi Gu, Jiani Liu, Yujing Liu, Jianlong Wei, Zhaoling Ma, Hengyue Xu, Jia Zhang, Hanwen Liu, Yiqiong Zhang, Shuangyin Wang   +10 more
wiley   +1 more source