Results 71 to 80 of about 67,204 (291)

Photoswitchable, Water‐Soluble Bisazobenzene Cross‐Linkers with Enhanced Properties for Biological Applications

ChemPhotoChem, Volume 6, Issue 12, December 2022., 2022
Photoswitchable cross‐linkers have the ability to connect two residues on a biomolecule, thereby causing large changes in the structure and function of the target upon irradiation. The design, synthesis and purification of cross‐linkers with large end‐to‐end distances remains challenging, especially for applications in chemical biology.
Jana Volarić, Sebastian Thallmair, Ben L. Feringa, Wiktor Szymanski   +3 more
wiley   +1 more source

Phenolic acids in leaves of Secamone afzelii (Rhoem.) Schult. (Asclepiadaceae)

Acta Societatis Botanicorum Poloniae, 2014
The analysis of the sets of free and liberated by hydrolysis phenolic acids in the leaves of, Secamone afzelii (Rhoem.) Schult. was conducted by 2D-TLC and RP-HPLC methods.
Renata Nowak, Sławomir Kawka
doaj   +1 more source

Electrophoretic detection of black market myostatin propeptide

Drug Testing and Analysis, Volume 14, Issue 11-12, Page 1812-1824, November-December 2022., 2022
Of the 12 black market products investigated, only nine contained the target protein among dozens of other proteins. In the remaining ones, small growth hormone‐related peptides were found by mass spectrometry (e.g., tesamorelin). A shotgun proteomics approach revealed that all nine products contained full length GST‐tags.
Christian Reichel, Günter Gmeiner, Mario Thevis   +2 more
wiley   +1 more source

The chromatographic study of complexation of functionalized calix[4,8]arenes with aromatic aldehydes

Журнал органічної та фармацевтичної хімії, 2019
Aim. To study the Host-Guest complexation of octakis(diphenoxyphosphoryloxy)-tetramethylcalix[4]resorcinarene (PRA), 5,17-bis(N-tolyl-iminomethyl)-25,27-dipropoxycalix[4]arene (IC4A), 5,11,17,23-tetrakis(diisopropoxyphosphonyl)-25,26,27,28-tetra ...
O. I. Kalchenko, S. O. Cherenok, A. V. Solovyov   +2 more
doaj   +1 more source

Oxidation of Cyclo‐Lino Peptides in Linseed Oils during Storage

European Journal of Lipid Science and Technology, Volume 124, Issue 12, December 2022., 2022
Storage lipids of linseeds are protected against oxidation by lignans, tocopherols and cyclo‐lino peptides. Oxidation of specific cyclo‐lino peptides in cold pressed linseed oils cause formation of a bitter off‐taste. This work elucidates the role of cyclo‐lino peptides and tocopherols during oxidation of linseed oil and examines their antioxidative ...
Ludger Brühl, Anja Bonte, Katharina N'Diaye, Bertrand Matthäus   +3 more
wiley   +1 more source

Convergent Assembly of Homo‐ and Heterotypic Ubiquitin Chains from Functionalized, Expressed Monomers via Thiol‐Ene Chemistry

Angewandte Chemie International Edition, EarlyView.
Generating functionalized ubiquitin building blocks via expression in E. coli paves the way to different di‐, tri‐, and tetra‐ubiquitin chains. Light‐induced thiol‐ene click reactions, combined with a masking and protection strategy, are harnessed to establish controlled ubiquitin chain assembly and to allow the semisynthesis of site‐selectively ...
Moritz Urschbach, Susanne Huhmann, Dominik Appel, Luca Ferrari, Dominik Vogl, Sascha Martens, Christian F. W. Becker   +6 more
wiley   +1 more source

Oligonucleotide separation techniques for purification and analysis: What can we learn for today's tasks?

ELECTROPHORESIS, Volume 43, Issue 23-24, Page 2402-2427, December 2022., 2022
Abstract Nucleic acids are the blueprint of life. They are not only the construction plan of the single cell or higher associations of them, but also necessary for function, communication and regulation. Due to the pandemic, the attention shifted in particular to their therapeutic potential as a vaccine. As pharmaceutical oligonucleotides are unique in
Robert Minkner, Jirayu Boonyakida, Enoch Y. Park, Hermann Wätzig   +3 more
wiley   +1 more source

Food metabolomics: Latest hardware—developments for nontargeted food authenticity and food safety testing

ELECTROPHORESIS, Volume 43, Issue 23-24, Page 2334-2350, December 2022., 2022
Abstract The analytical requirements for food testing have increased significantly in recent years. On the one hand, because food fraud is becoming an ever‐greater challenge worldwide, and on the other hand because food safety is often difficult to monitor due to the far‐reaching trade chains.
Marina Creydt, Markus Fischer
wiley   +1 more source

Unlocking Lactonase Enzymes as Biocatalysts for the Deracemization of Chiral γ‐Thiolactones

Angewandte Chemie International Edition, Accepted Article.
Lactonases, a class of metalloenzymes that exhibit catalytic promiscuity, have been extensively studied from a biological perspective, yet their application as biocatalysts remains underexplored. In this study, we disclose the biocatalytic activity of lactonase enzymes in the hydrolysis and deracemization of chiral C3‐substituted‐γ‐thiolactones and the
Jingyue Wu, Michele Crotti, Ivan Bassanini, Mahdi Hassankalhori, Erica Elisa Ferrandi, Ferran Sancho, Daniela Monti, Daniele Castagnolo   +7 more
wiley   +1 more source

Switching positions: Assessing the dynamics of conjugational heterogeneity in antibody–drug conjugates using CE‐SDS

ELECTROPHORESIS, Volume 44, Issue 1-2, Page 62-71, January 2023., 2023
Abstract Antibody–drug conjugates (ADCs) are a prospective class of new oncology therapeutics with the ability to deliver a cytotoxic drug to a targeted location. The concept appears simple, but ADCs are highly complex due to their intrinsic heterogeneity. Randomly conjugated ADCs, for instance, are composed of conjugated species carrying between 0 and
Eline B. A. van den Berg, Jaap C. W. Hendriks, Everdine W. Elsinga, Mark Eggink, Eef H. C. Dirksen   +4 more
wiley   +1 more source