Results 51 to 60 of about 5,509 (234)

Highly Sensitive Spatial Host‐Microbiome Transcriptomics in FFPE Tissues via Iterative Hydrogel Expansion

Advanced Science, EarlyView.
Ex‐spRandom is a spatial transcriptomics platform that synergizes random‐primed chemistry with iterative hydrogel expansion. By physically decrowding the dense FFPE matrix, this scalable technology shatters the traditional resolution‐sensitivity barrier.
Shunji Zhang, Mengyuan Wang, Jiaye Chen, Yuyi Zhu, Bin Zhu, Ziye Xu, Yuan Liao, Yongcheng Wang   +7 more
wiley   +1 more source

An Extracellular Pore‑Targeting Peptide Defines a Designable Allosteric Site in TRPV2

Advanced Science, EarlyView.
Structure‐guided peptide engineering yields Depiv2, a highly potent and subtype‐selective TRPV2 inhibitor that binds to the extracellular pore and remodels it into a closed, non‐conductive state. Depiv2 suppresses pathological cardiac hypertrophy, establishing the TRPV2 outer pore as a designable interface for selective peptide modulation.
Aiqin Zhu, Hongkun Wang, Jiawei Wang, Xiaolu Liu, Aerziguli Aierken, Lizhen Xu, Ping Liang, Fan Yang   +7 more
wiley   +1 more source

Dissociated Retinal Cell Culture

Bio-Protocol, 2014
The retina is a relatively simple and accessible part of the central nervous system, making it a powerful model to study cell fate specification mechanisms.
Christine Jolicoeur, Michel Cayouette
doaj   +1 more source

Rapidly progressive cerebellar syndrome as a manifestation of paraneoplastic brain damage. A case report

Клинический разбор в общей медицине, 2023
Introduction. Rapidly progressive cerebellar syndrome (RPCS), previously referred to as “subacute cerebellar degeneration” or “paraneoplastic cerebellar degeneration”, is an autoimmune disorder, wich in the most cases is associated with a malignancy ...
Vera N. Grigoryeva, Ekaterina A. Ruina , Yulia V. Baranceva   +2 more
doaj   +1 more source

Essential Updates in the Surgical Management of Inflammatory Bowel Disease: Current Topics From 2024 to Mid‐2026

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Inflammatory bowel disease management has undergone a major transformation with the introduction of treat‐to‐target strategies and highly effective biologic and small‐molecule therapies. Although these advances have reduced the overall requirement for surgery, operative intervention remains essential for selected patients with ulcerative ...
Yoshiki Okita, Tadanobu Shimura, Mikio Kawamura, Yuhki Koike, Yuji Toiyama   +4 more
wiley   +1 more source

Effects of Low-dose Triamcinolone Acetonide on Rat Retinal Progenitor Cells under Hypoxia Condition

Chinese Medical Journal, 2016
Background: Retinal degenerative diseases are the leading causes of blindness in developed world. Retinal progenitor cells (RPCs) play a key role in retina restoration. Triamcinolone acetonide (TA) is widely used for the treatment of retinal degenerative
Yao Xing, Li-Jun Cui, Qian-Yan Kang
doaj   +1 more source

Study of Thin Double-Gap RPCs for the CMS Muon System

, 2017
High-sensitivity double-gap phenolic resistive plate chambers (RPCs) are studied for the Phase-2 upgrade of the Compact Muon Solenoid (CMS) muon system at high pseudorapidity η. Whereas the present CMS RPCs have a gas gap thickness of 2 mm, we propose to
Lista, L, Voevodina, E, Aleksandrov, Alexander, Aly, R, Manisha, M, Aly, S, Mohamed, A., Gelmi, A., Gelmi, A, Sharma, A, Muhammad, S., Zagandis, N., Voevodina, E., Mahrous, A, Montagna, P., Montoya, C.Carrillo, Mora, A.Cabrera, Ryoo, K.R., Iaydjiev, P, Hwang, C., Montagna, P, Buontempo, S., Gouzevitch, M, Sharma, A., Salvini, P., Kumari, P, Singh, J, Constantini, S, Valencia, F Vazquez, Riccardi, C, Tsamalaidze, Z., Roskas, C., Lagarde, F, Pant, L., Benussi, L, Boghrati, B., Petkov, P., Laktineh, I., Salvini, P, Primavera, F., Dimitrov, A., Paolucci, P, Hwang, C, Buontempo, S, Wang, Y., Petkov, P, Grenier, G, Iaselli, G., Assran, Y., Fagot, A, Ban, Y, Lim, J.H., Aly, S., Mahrous, A., Hong, B, Hoorani, H., Montoya, C Carrillo, Bianc, S., Kim, T., Lim, J H, Park, S K, Toriashvili, T., Orso, A, Najafabadi, Mora, A Cabrera, Qian, S, Abbrescia, M, Fagot, A., Moreno, S.Carrillo, Tsamalaidze, Z, Valencia, F.Vazquez, Castilla-Valdez, H, Hong, B., Soultanov, G, Aly, R., Primavera, F, Wang, Y, Crotty, I., Moreno, S Carrillo, Meola, S, Kumari, P., Boghrati, B, Bagaturia, I., Maggi, M, Laktineh, I, Buonaura, A, Di Crescenzo, A, Benussi, L., Lomidze, D., Litov, L, Kang, M, Jo, Y M, Sanchez-Hernandez, A, Jeong, S, Assran, Y, Goh, J, Rodozov, M., Hoorani, H, Vutiva, M., Pavlov, B., Yu, I, Cho, S.W., Litov, L., Galati, G., Shah, M., Kang, M., Hadjiiska, R, Pavlov, B, Vitulo, P, Vitulo, P., Soultanov, G., Gouzevitch, M., Gul, M., Roskas, C, Fienga, F, Tytgat, M., Grenier, G., Braghieri, A., Iaydjiev, P., Iaselli, G, Estrada, C.Uribe, Sanchez-Hernandez, A., Jo, Y.M., Kim, T, Bernal, C., Vutiva, M, Galati, G, Dimitrov, A, Ryoo, K R, Gul, M, Gupta, R, Toriashvili, T, Mohammadi, M, Estrada, C Uribe, Pedraza, I., Hadjiiska, R., Han, D., Singh, J., Jeong, S., Pugliese, G, Bhatnagar, V, Qian, S., Piccolo, D., Bhatnagar, V., Riccardi, C., Mohamed, A, Eysermans, J., Mohammadi, M., Bianc, S, Lista, L., Cho, S W, Orso, A., Yu, I., Paolucci, P., Lomidze, I., Shah, M, Constantini, S., Di Crescenzo, A., Fienga, F., Ban, Y., Eysermans, J, Park, S.K., Lee, K S, Zagandis, N, Pant, L, Muhammad, S, Han, D, Abbrescia, M., Maggi, M., Manisha, M., Gupta, R., Castilla-Valdez, H., Choi, S, Piccolo, D, Lee, K.S., Buonaura, A., Bagaturia, I, Pedraza, I, Tytgat, M, Goh, J., Meola, S., Najafabadi, M., Lagarde, Fabienne, Braghieri, A, Aleksandrov, A, Lomidze, D, Choi, S., Crotty, I, Pugliese, G., Lomidze, I, Bernal, C, Rodozov, M, Ryoo, K. R., Montoya, C. C., Lagarde, F., Najafabadi, Najafabadi, Fagot, Alexis, Park, S. K., Lee, K. S., Lim, J. H., Roskas, Christos, Mora, A. C., Jo, Y. M., Vazquez Valencia, F., Estrada, C. U., Uribe Estrada, C., Gül, Mert, Cabrera Mora, A., Cho, S. W., Carrillo Moreno, S., Valencia, F. V., Aleksandrov, A., Carrillo Montoya, C., Moreno, S. C., Tytgat, Michael   +214 more
core   +1 more source

Improving Load Balancing of Long-lived Streaming RPCs for gRPC-enabled Inter-service Communication

, 2023
Many companies have adopted gRPC since 2015 for their microservices architecture due to its efficient communication method, particularly regarding streaming data.
Ghofrani, Javad, Starck, Christopher
core   +1 more source

Physiological and pathological roles of FATP-mediated lipid droplets in Drosophila and mice retina. [PDF]

PLoS Genetics, 2018
Increasing evidence suggests that dysregulation of lipid metabolism is associated with neurodegeneration in retinal diseases such as age-related macular degeneration and in brain disorders such as Alzheimer's and Parkinson's diseases.
Daan M Van Den Brink, Aurélie Cubizolle, Gilles Chatelain, Nathalie Davoust, Victor Girard, Simone Johansen, Francesco Napoletano, Pierre Dourlen, Laurent Guillou, Claire Angebault-Prouteau, Nathalie Bernoud-Hubac, Michel Guichardant, Philippe Brabet, Bertrand Mollereau   +13 more
doaj   +1 more source

Integrative Single‐Cell Transcriptomics and Epigenomics Mapping of the Fetal Retina Developmental Dynamics

Advanced Science, 2023
The underlying mechanisms that determine gene expression and chromatin accessibility in retinogenesis are poorly understood. Herein, single‐cell RNA sequencing and single‐cell assay for transposase‐accessible chromatin sequencing are performed on human ...
Ruonan Li, Jiangyi Liu, Ping Yi, Xianli Yang, Jun Chen, Chenyang Zhao, Xingyun Liao, Xiaotang Wang, Zongren Xu, Huiping Lu, Hongshun Li, Zhi Zhang, Xianyang Liu, Junjie Xiang, Ke Hu, Hongbo Qi, Jia Yu, Peizeng Yang, Shengping Hou   +18 more
doaj   +1 more source