Results 1 to 10 of about 18,590,986 (140)

Edodin: A New Type of Toxin from Shiitake Mushroom (Lentinula edodes) That Inactivates Mammalian Ribosomes [PDF]

Toxins
Ribosome-inactivating proteins (RIPs) are a group of proteins with rRNA N-glycosylase activity that irreversibly inhibit protein synthesis and consequently cause cell death.
Lucía Citores, Sara Ragucci, Claudia C. Gay, Rosita Russo, Angela Chambery, Antimo Di Maro, Rosario Iglesias, José M. Ferreras   +7 more
doaj   +2 more sources

Isolation, Characterization and Biological Action of Type-1 Ribosome-Inactivating Proteins from Tissues of Salsola soda L.

Toxins, 2022
Ribosome-inactivating proteins (RIPs) are known as RNA N-glycosylases. They depurinate the major rRNA, damaging ribosomes and inhibiting protein synthesis.
Nicola Landi, Sara Ragucci, Lucía Citores, Angela Clemente, Hafiza Z. F. Hussain, Rosario Iglesias, José M. Ferreras, Antimo Di Maro   +7 more
doaj   +1 more source

Sapovaccarin-S1 and -S2, Two Type I RIP Isoforms from the Seeds of Saponaria vaccaria L.

Toxins, 2022
Type I ribosome-inactivating proteins (RIPs) are plant toxins that inhibit protein synthesis by exerting rRNA N-glycosylase activity (EC 3.2.2.22). Due to the lack of a cell-binding domain, type I RIPs are not target cell-specific. However once linked to
Louisa Schlaak, Christoph Weise, Benno Kuropka, Alexander Weng   +3 more
doaj   +1 more source

Structure and Biological Properties of Ribosome-Inactivating Proteins and Lectins from Elder (Sambucus nigra L.) Leaves

Toxins, 2022
Ribosome-inactivating proteins (RIPs) are a group of proteins with rRNA N-glycosylase activity that catalyze the removal of a specific adenine located in the sarcin–ricin loop of the large ribosomal RNA, which leads to the irreversible inhibition of ...
Rosario Iglesias, Rosita Russo, Nicola Landi, Mariangela Valletta, Angela Chambery, Antimo Di Maro, Andrea Bolognesi, José M. Ferreras, Lucía Citores   +8 more
doaj   +1 more source

Ribosomal RNA N-glycosylase Activity Assay of Ribosome-inactivating Proteins

Bio-Protocol, 2017
Ribosome-inactivating proteins (RIPs) are enzymes that irreversibly inactivate ribosomes as a consequence of their N-glycosylase (EC 3.2.2.22) activity. The enzyme cleaves the N-glycosidic bond between the adenine No.
José Ferreras, Lucía Citores, José Ferreras   +2 more
doaj   +1 more source

Bouganin, an Attractive Weapon for Immunotoxins

Toxins, 2018
Bougainvillea (Bougainvillea spectabilis Willd.) is a plant widely used in folk medicine and many extracts from different tissues of this plant have been employed against several pathologies.
Massimo Bortolotti, Andrea Bolognesi, Letizia Polito   +2 more
doaj   +1 more source

Ricin: An Ancient Story for a Timeless Plant Toxin

Toxins, 2019
The castor plant (Ricinus communis L.) has been known since time immemorial in traditional medicine in the pharmacopeia of Mediterranean and eastern ancient cultures. Moreover, it is still used in folk medicine worldwide.
Letizia Polito, Massimo Bortolotti, Maria Giulia Battelli, Giulia Calafato, Andrea Bolognesi   +4 more
doaj   +1 more source

Saporin-S6: A Useful Tool in Cancer Therapy

Toxins, 2013
Thirty years ago, the type 1 ribosome-inactivating protein (RIP) saporin-S6 (also known as saporin) was isolated from Saponaria officinalis L. seeds. Since then, the properties and mechanisms of action of saporin-S6 have been well characterized, and it ...
Letizia Polito, Massimo Bortolotti, Daniele Mercatelli, Maria Giulia Battelli, Andrea Bolognesi   +4 more
doaj   +1 more source

Melleatin, an antibiofilm multitasking protein with rRNA N-glycosylase and nuclease activity from Armillaria mellea fruiting bodies

International Journal of Biological Macromolecules
Several studies highlight the identification of some enzymes with additional abilities, especially those involved in metabolic pathways and/or host defence processes, classified as multitasking proteins. In this context, we report the characterization of melleatin (17.5-kDa), a multitasking enzyme isolated from Armillaria mellea fruiting bodies ...
Hussain, Hafiza Z F, Ragucci, Sara, Gentile, Maria Teresa, Alberico, Laura, Landi, Nicola, Bosso, Andrea, Pizzo, Elio, Saviano, Michele, Pedone, Paolo V, Citores, Lucía, Woodrow, Pasqualina, Di Maro, Antimo   +11 more
openaire   +3 more sources

Structure of Ribosome-Inactivating Protein from <i>Mirabilis jalapa</i> and Its L12-Stalk-Dependent Inhibition of <i>Escherichia coli</i> Ribosome. [PDF]

Toxins (Basel)
Nishida N, Ninomiya Y, Yoshida T, Tanzawa T, Maki Y, Yoshida H, Tsuge H, Habuka N.   +7 more
europepmc   +1 more source