Results 1 to 10 of about 5,505 (142)

Edodin: A New Type of Toxin from Shiitake Mushroom (Lentinula edodes) That Inactivates Mammalian Ribosomes [PDF]

Toxins
Ribosome-inactivating proteins (RIPs) are a group of proteins with rRNA N-glycosylase activity that irreversibly inhibit protein synthesis and consequently cause cell death.
Lucía Citores, Sara Ragucci, Claudia C. Gay, Rosita Russo, Angela Chambery, Antimo Di Maro, Rosario Iglesias, José M. Ferreras   +7 more
doaj   +2 more sources

Isolation, Characterization and Biological Action of Type-1 Ribosome-Inactivating Proteins from Tissues of Salsola soda L.

Toxins, 2022
Ribosome-inactivating proteins (RIPs) are known as RNA N-glycosylases. They depurinate the major rRNA, damaging ribosomes and inhibiting protein synthesis.
Nicola Landi, Sara Ragucci, Lucía Citores, Angela Clemente, Hafiza Z. F. Hussain, Rosario Iglesias, José M. Ferreras, Antimo Di Maro   +7 more
doaj   +1 more source

Sapovaccarin-S1 and -S2, Two Type I RIP Isoforms from the Seeds of Saponaria vaccaria L.

Toxins, 2022
Type I ribosome-inactivating proteins (RIPs) are plant toxins that inhibit protein synthesis by exerting rRNA N-glycosylase activity (EC 3.2.2.22). Due to the lack of a cell-binding domain, type I RIPs are not target cell-specific. However once linked to
Louisa Schlaak, Christoph Weise, Benno Kuropka, Alexander Weng   +3 more
doaj   +1 more source

Structure and Biological Properties of Ribosome-Inactivating Proteins and Lectins from Elder (Sambucus nigra L.) Leaves

Toxins, 2022
Ribosome-inactivating proteins (RIPs) are a group of proteins with rRNA N-glycosylase activity that catalyze the removal of a specific adenine located in the sarcin–ricin loop of the large ribosomal RNA, which leads to the irreversible inhibition of ...
Rosario Iglesias, Rosita Russo, Nicola Landi, Mariangela Valletta, Angela Chambery, Antimo Di Maro, Andrea Bolognesi, José M. Ferreras, Lucía Citores   +8 more
doaj   +1 more source

Capturing the ‘ome’ : the expanding molecular toolbox for RNA and DNA library construction [PDF]

, 2018
All sequencing experiments and most functional genomics screens rely on the generation of libraries to comprehensively capture pools of targeted sequences.
Boone, Morgane, Callewaert, Nico, De Koker, Andries   +2 more
core   +2 more sources

Ribosomal RNA N-glycosylase Activity Assay of Ribosome-inactivating Proteins

Bio-Protocol, 2017
Ribosome-inactivating proteins (RIPs) are enzymes that irreversibly inactivate ribosomes as a consequence of their N-glycosylase (EC 3.2.2.22) activity. The enzyme cleaves the N-glycosidic bond between the adenine No.
José Ferreras, Lucía Citores, José Ferreras   +2 more
doaj   +1 more source

Bouganin, an Attractive Weapon for Immunotoxins

Toxins, 2018
Bougainvillea (Bougainvillea spectabilis Willd.) is a plant widely used in folk medicine and many extracts from different tissues of this plant have been employed against several pathologies.
Massimo Bortolotti, Andrea Bolognesi, Letizia Polito   +2 more
doaj   +1 more source

DNA methylation, the early-life social environment and behavioral disorders [PDF]

, 2011
One of the outstanding questions in behavioral disorders is untangling the complex relationship between nurture and nature. Although epidemiological data provide evidence that there is an interaction between genetics (nature) and the social and physical ...
Moshe Szyf
core   +1 more source

Comparative genomics of Burkholderia singularis sp. nov., a low G+C content, free-living bacterium that defies taxonomic dissection of the genus Burkholderia [PDF]

, 2017
Four Burkholderia pseudomallei-like isolates of human clinical origin were examined by a polyphasic taxonomic approach that included comparative whole genome analyses.
Anthony Baker, Aurélien Carlier, Bart J. Currie, Birgit De Smet, Charlotte Peeters, Deborah A. Henry, Derek S. Sarovich, Derek S. Sarovich, Erin P. Price, Erin P. Price, James E. A. Zlosnik, Jeffrey Warner, Mark Mayo, Peter Vandamme, Trevor J. Hird   +14 more
core   +13 more sources

DNA demethylation pathways: Additional players and regulators. [PDF]

, 2017
DNA demethylation can occur passively by "dilution" of methylation marks by DNA replication, or actively and independently of DNA replication. Direct conversion of 5-methylcytosine (5mC) to cytosine (C), as originally proposed, does not occur.
Abdouni, An, Arakawa, Barreto, Bellon, Bhutani, Bhutani, Blaschke, Boorstein, Bourc'his, Bransteitter, Brown, Buganim, Chakraborty, Chen, Chen, Chen, Chowdhury, Chung, Cortazar, Cortellino, Costa, Dai, Dai, Dang, Dawlaty, Dawlaty, Dawlaty, Delhommeau, Doege, Dominguez, Engel, Fortini, Foshay, Fousteri, Franchini, Fritz, Fritz, Gao, Ge, Gehring, Gjini, Grin, Gu, Guo, Guo, Habib, Hajkova, Hashimoto, Hashimoto, Hashimoto, Hashimoto, Hata, Hata, He, Henson, Hildrestrand, Hogenbirk, Hollander, Hon, Hu, Hu, Iiams, Inoue, Iqbal, Ito, Iyer, Jin, Jin, Jiricny, Jones, Kagiwada, Kaneda, Kellinger, Ko, Kosmider, Kou, Kriaucionis, Krokan, Kumar, Langemeijer, Larijani, Laukka, Lenz, Li, Li, Li, Li, Liu, Liutkeviciute, Lorsbach, Lu, Ma, Maiti, Maiti, Marusawa, Mayer, Moran-Crusio, Muller, Muramatsu, Muramatsu, Nabel, Nakanishi, Nemec, Niehrs, Nilsen, Ohno, Okano, Ooi, Pais, Pastor, Perez, Petersen-Mahrt, Pfaffeneder, Pollard, Popp, Rai, Raiber, Ramiro, Rangam, Revy, Rommel, Rusmintratip, Sabag, Sajadian, Santos, Schiesser, Schiesser, Schmitz, Schomacher, Sciacovelli, Sejersted, Shen, Shen, Shibutani, Shimamoto, Shimoda, Silverman, Spruijt, Stier, Szulik, Tahiliani, Tamura, Tan, Vartanian, Verdine, Wagner, Wang, Weber, Wijesinghe, Wojciechowski, Wu, Xiao, Xu, Xu, Xu, Xue, Yamazaki, Yin, Young, Zanotti, Zhao, Zhu   +162 more
core   +1 more source