Results 41 to 50 of about 18,590,986 (140)

Optimization of N-piperidinyl-benzimidazolone derivatives as potent and selective inhibitors of 8-Oxo Guanine DNA Glycosylase 1 [PDF]

, 2021
8-oxo Guanine DNA Glycosylase 1 is the initiating enzyme within base excision repair and removes oxidized guanines from damaged DNA. Since unrepaired 8-oxoG could lead to G:C→T:A transversion, base removal is of the utmost importance for cells to ensure ...
Geoffrey, Masuyer, Christina , Kalderén, Maurice, Michel, Thomas, Lundbäck, Ulrika, Warpman Berglund, Thomas, Helleday, Armando, Cázares-Körner, Olov, Wallner, Martin, Scobie, Olga, Loseva, Florian, Ortis, Monica, Pandey, Pål, Stenmark, Tobias, Koolmeister, Elisée, Wiita, Evert, Homan, Emma Rose, Scaletti, Tove, Bekkhus, Kirill, Mamonov, Carlos, Benítez-Buelga, Torkild, Visnes, Maria, Volkova, Jonathan, Davies   +22 more
core   +1 more source

The synthetic estradiol analog E0703 enhances Akkermansia muciniphila growth for radiation‐induced intestinal damage repair

mLife, Volume 5, Issue 2, Page 199-216, April 2026.
Abstract The development of safe and effective radioprotective agents with minimal side effects, particularly for high‐dose exposure, remains a global priority. E0703, a novel steroidal compound structurally derived from estradiol, has shown promising radioprotective efficacy with limited estrogenic activity in prior pharmacodynamic studies.
Zhexin Ni, Ziqiao Yan, Mingyang Chang, Yangshuo Li, Zebin Liao, Tiantian Xia, Zhijie Bai, Ningning Wang, Chaoji Huangfu, Dezhi Sun, Yangyi Hu, Liangliang Zhang, Feiran Hao, Yongqi Dou, Pan Shen, Wei Zhou, Yue Gao   +16 more
wiley   +1 more source

Ribosome-inactivating and adenine polynucleotide glycosylase activities in Mirabilis jalapa L. tissues

, 2002
Several tissues of Mirabilis jalapa L. (Nyctaginaceae) were assayed for inhibition of translation by a rabbit reticulocyte lysate (as a signal of ribosome-inactivating activity) and for adenine DNA glycosylase activity, activities that are both due to ...
Parente A., Polito L., Lubelli C., Barbieri L., Bolognesi A., Stirpe F.   +5 more
core   +1 more source

Bacteriophage Therapy: Current Strategies and Future Perspectives

MedComm, Volume 7, Issue 3, March 2026.
This manuscript systematically reviews the expanding scope of phage applications. It moves beyond traditional antibacterial use to explore their role in precision therapies against drug‐resistant infections, their synergy with antibiotics, and advanced biomaterial‐assisted delivery systems.
Zihe Zhou, Hanyu Fu, Mengzhe Li, Zhongyu Han, Zhenchao Wu, Huahao Fan, Ning Shen, Jiajia Zheng   +7 more
wiley   +1 more source

Altered expression of the DNA repair protein, N-methylpurine-DNA glycosylase (MPG), in breast cancer [PDF]

, 1998
We examined expression of N-methylpurine-DNA glycosylase (MPG), a DNA repair enzyme that removes N-alkylpurine damage, in normal, malignant, and immortalized breast epithelial cells, and breast cancer cell lines (MDA-MB-231, MCF7, T47D).
Weitzman, Sigmund A, Cerda, Sonia R, Turk, Patrick W, Patrick W Turk, Ann D Thor, Sigmund A Weitzman, Sonia R Cerda, Thor, Ann D   +7 more
core   +1 more source

Microbial metabolites in tumor epigenetic regulation

iMeta, Volume 5, Issue 1, February 2026.
The gut microbiome modulates tumor epigenetic regulation through bioactive metabolites derived from dietary substrates. Microbiota‐produced SCFAs, secondary BAs, one‐carbon metabolites, and tryptophan‐derived ligands regulate histone acetylation, DNA methylation, and chromatin remodeling via HDAC, DNMT, AhR, and metabolic cofactor‐dependent pathways ...
Wangzheqi Zhang, Haoling Zhang, Yan Liao, Shuya Jiang, Haolong Zhang, Chenwei Huang, Zhijing Song, Rui Zhao, Ping Lu, Xiaohong Kang, Eryan Kong, Yalin Zhu, Wei Wang, Xuesong Liu, Yisheng Chen, Zhiwen Luo, Zhaoyu Li, Di Wang, Na Xing, Yadong Guo, Jingjing Zhang, Xiaojing Wang, Wenyi Wang, Mowaffaq Adam, Bakiah Shaharuddin, Muhamad Yusri Musa, Doblin Sandai, Chenglong Zhu, Aimin Jiang, Peng Luo, Zhijie Zhao, Zui Zou   +31 more
wiley   +1 more source

The Protist Ribosomal Reference database (PR2): a catalog of unicellular eukaryote Small Sub-Unit rRNA sequences with curated taxonomy [PDF]

, 2012
The interrogation of genetic markers in environmental meta-barcoding studies is currently seriously hindered by the lack of taxonomically curated reference data sets for the targeted genes.
Probert, Ian, Dolan, John R., Kooistra, Wiebe H.C.F., Guillou, Laure, Vaulot, Daniel, Campo, Javier, Del, Morard, Raphael, Bass, David, Logares, Ramiro, Montresor, Marina, del Campo, Javier, Lara, Enrique, Berney, Cédric, Zimmermann, Pascal, Burgaud, Gaétan, Pawlowski, Jan, Campo, Javier,, Bachar, Dipankar, Boutte, Christophe, Bittner, Lucie, Christen, Richard, Mahe, Frédéric, Dunthorn, Micah, Kooistra, Wiebe H. C. F., ,, Siano, Raffaele, Stoeck, Thorsten, Le Bescot, Noan, Audic, Stéphane, Decelle, Johan, Not, Fabrice, Massana, Ramon, de Vargas, Colomban, Sauvadet, Anne-Laure, Edvardsen, Bente, Holzmann, Maria   +35 more
core   +1 more source

Ricin as a Biothreat Agent: From Molecular Mechanisms to Clinical Toxicology, Forensic Aspects, and Risk Mitigation

BioMed Research International, Volume 2026, Issue 1, 2026.
Ricin, a potent ribosome‐inactivating protein derived from the seeds of Ricinus communis L., represents a significant threat in the context of biological warfare and terrorism due to its high toxicity, ease of extraction, and lack of a specific antidote.
Miroslav Pohanka, Poorani Gurumallesh Prabu   +1 more
wiley   +1 more source

LAMP‐Based Detection of Candida albicans: A Potential Tool for Candidemia Diagnosis

Canadian Journal of Infectious Diseases and Medical Microbiology, Volume 2026, Issue 1, 2026.
Candidemia is a life‐threatening bloodstream infection, most commonly caused by Candida albicans (C. albicans), and remains a significant concern in immunocompromised patients. Rapid and accurate species‐level detection is essential for effective clinical management.
Eakkapote Prompunt, Kannika Jamnai, Nawapol Marome, Nathaporn Phutthawong, Thitima Sumphanapai, Parin Kamseng, Chiraphat Kloypan, Somphot Saoin, Supaporn Khamchun, Sawitree Nangola, Julia Uhanova   +10 more
wiley   +1 more source

Targeted rapid amplification of cDNA ends (T-RACE)-an improved RACE reaction through degradation of non-target sequences [PDF]

, 2010
Amplification of the 5' ends of cDNA, although simple in theory, can often be difficult to achieve. We describe a novel method for the specific amplification of cDNA ends. An oligo-dT adapter incorporating a dUTP-containing PCR primer primes first-strand
Bower, Neil I., I. A. Johnston, N. I. Bower, Johnston, Ian A.   +3 more
core   +1 more source