Results 51 to 60 of about 18,590,986 (140)

Biosynthesis of H2S and Siderophores Targeting Gram‐Negative Bacterial Resistance to Reactive Oxygen Species

Advanced Science, Volume 12, Issue 45, December 4, 2025.
Discover how Gram‐negative bacteria develop resistance to reactive oxygen species, and how scientists aim to overcome this challenge. Abstract Reactive oxygen species (ROS) are a promising alternative bactericide. However, it is questioned that bacteria can potentially develop resistance to ROS, similar to their resistance against antibiotics and ...
Congyang Mao, Wanyu Jin, Yiming Xiang, Yizhou Zhu, Jun Wu, Xiangmei Liu, Shuilin Wu, Wei Qiao, Kenneth M. C. Cheung, Kelvin Wai Kwok Yeung   +9 more
wiley   +1 more source

A rapid, safe, and quantitative in vitro assay for measurement of uracil-DNA glycosylase activity. [PDF]

, 2019
Base excision repair (BER) is a frontline repair mechanism that operates through the G1 phase of the cell cycle, which ensures the genome integrity by repairing thousands of DNA lesions due to endogenous and exogenous agents.
Melone Mariarosa Anna Beatrice, Galderisi Umberto., Di Bernardo Giovanni, Finicelli M, Alessio N, Peluso G2, Del Gaudio S, Squillaro T   +7 more
core   +1 more source

Epigenetic dynamics in gastric cancer precancerous lesions: From molecular mechanisms to precision risk stratification

Clinical and Translational Discovery, Volume 5, Issue 6, December 2025.
Gastric precancerous lesions undergo dynamic epigenetic alterations—including DNA methylation, 5‐hydroxymethylcytosine, non‐coding RNAs, and RNA editing—throughout the Correa's cascade. The integration of these multi‐omics epigenetic signatures facilitates non‐invasive risk stratification, which guides personalised surveillance strategy and targeted ...
Kewei Ma, Guanqi Shi, Xiao Li, Wanwei Zheng, Zhongguang Luo   +4 more
wiley   +1 more source

Abstracts

Molecular Oncology, Volume 20, Issue S1, Page 1-692, August 2026.
Abstracts submitted to the ‘EACR 2026 Congress: Innovative Cancer Science’, from 08–11 June 2026 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley   +1 more source

Radiation‐Induced Biological Effects: Molecular and Cellular Mechanism, and Applications to Radiation/Nuclear Emergency and Cancer Therapy

MedComm, Volume 6, Issue 12, December 2025.
Radiation‐induced biological effects are an extremely complex and extensive mechanism that involves multiple aspects of physiological activities in organisms. In the medical field, utilizing the damaging effects of radiation to treat tumors is a commonly employed therapeutic approach.
Zhihe Hu, Yan Chen, Shengyi Yang, Shihai Diao, Le Ma, Chunmeng Shi   +5 more
wiley   +1 more source

Nop53p is required for late 60S ribosome subunit maturation and nuclear export in yeast [PDF]

, 2005
We report that Ypl146cp/Nop53p is associated with pre-60S ribosomal complexes and localized to the nucleolus and nucleoplasm. in cells depleted of Nop53p synthesis of the rRNA components of the 60S ribosomal subunit is severely inhibited, with strikingly
Tollervey, D, Thomson, E
core   +1 more source

Epigenetic regulation modulates seasonal temperature‐dependent growth of soybean in southern China

Plant Biotechnology Journal, Volume 23, Issue 10, Page 4580-4601, October 2025.
Summary Epigenetic variations, including DNA methylation and small RNAs, are crucial for plant stress adaptation. However, their association with soybean adaptation to natural environments remains unclear. Through multi‐omics analyses, we investigate soybeans from distinct geographical regions (Northern China: HH43, Southern China: HX3, and Wm82) and ...
Yuan Fang, Yapeng Han, Yijie Fang, Jin Sun, Chuxin Lin, Birra Bukhari, Dong Zhou, Bin Liu, Changkui Guo, Yingxiang Wang   +9 more
wiley   +1 more source

Characterization of B Cell Responses in Rainbow Trout (Oncorhynchus Mykiss) Affected by Red Mark Syndrome

Advanced Science, Volume 12, Issue 35, September 18, 2025.
This study extensively characterizes the B cell response of rainbow trout (Oncorhynchus mykiss) in response to red mark syndrome (RMS). This disease, suspected to be caused by a Midichloria‐like organism (MLO), induces skin lesions in the infected animals, characterized by a massive influx of IgM+ B cells.
J Germán Herranz‐Jusdado, Samuel Vicente‐Gil, Esther Morel, Pablo Jiménez‐Barrios, Rocío Simón, Pedro Perdiguero, Diana Martín, Marta Vargas‐Ramírez, Niels Lorenzen, Jacob Günther Schmidt, Carolina Tafalla   +10 more
wiley   +1 more source

Mitochondria‐Targeting Abasic Site‐Reactive Probe (mTAP) Enables the Manipulation of Mitochondrial DNA Levels

Angewandte Chemie, Volume 137, Issue 36, September 1, 2025.
Mitochondria‐targeting water‐soluble probe mTAP exclusively reacts with mitochondrial abasic sites, enabling the manipulation of mitochondrial DNA levels under genotoxic stress. Abstract Mitochondrial DNA (mtDNA) encodes essential genes for mitochondrial and cellular functions and acts as a cell signaling molecule in innate immune and inflammatory ...
Anal Jana, Yu‐Hsuan Chen, Linlin Zhao
wiley   +1 more source

Nucleobase catalysts for the enzymatic activation of 8-oxoguanine DNA glycosylase 1 [PDF]

: Bifunctional DNA glycosylases employ an active site lysine or the N-terminus to form a Schiff base with the abasic site (AP site) base excision repair (BER) intermediate. Cleaving this reversible structure is the rate-determining step in the initiation
Kaixin, Zhou, Adam, Dickey, Maurice, Michel, Thomas, Helleday, Maeve, Long, Martin, Scobie, Holly , Dawson, Mikhael E., Astorga, Pål, Stenmark, Elisée, Wiita, Ingrid, Almlöf, Sara, Kosenina, Evert J, Homan, Liuzhen, Meng, Josephine, Stewart, Patricia, Calvo, Olov, Wallner, Leandro, Sastre, Nicholas, D\u27Arcy-Evans, Emily C., Hank, Florian , Ortis, Andreas, Krämer, Miguel, de Vega, Stefan, Knapp, Marek, Varga, Emma Rose, Scaletti, Carlos, Benítez-Buelga, Ann-Sofie, Jemth   +27 more
core   +2 more sources