In vitro approaches to assess the effects of açai (Euterpe oleracea) digestion on polyphenol availability and the subsequent impact on the faecal microbiota [PDF]
A considerable proportion of dietary plant-polyphenols reach the colon intact; determining the effects of these compounds on colon-health is of interest.
Adele F. Costabile +47 more
core +2 more sources
Abstract The development of safe and effective radioprotective agents with minimal side effects, particularly for high‐dose exposure, remains a global priority. E0703, a novel steroidal compound structurally derived from estradiol, has shown promising radioprotective efficacy with limited estrogenic activity in prior pharmacodynamic studies.
Zhexin Ni +16 more
wiley +1 more source
Differential expression of heme oxygenase-1 and vascular endothelial growth factor in cadaveric and living donor kidneys after ischemia-reperfusion [PDF]
The extent of graft damage after ischemia-reperfusion reflects the balance between deleterious events and protective factors. Heme oxygenase-1 (HO-1) and vascular endothelial growth factor (VEGF) may contribute to cytoprotection by ...
Baan, C.C. (Carla) +7 more
core +3 more sources
Bacteriophage Therapy: Current Strategies and Future Perspectives
This manuscript systematically reviews the expanding scope of phage applications. It moves beyond traditional antibacterial use to explore their role in precision therapies against drug‐resistant infections, their synergy with antibiotics, and advanced biomaterial‐assisted delivery systems.
Zihe Zhou +7 more
wiley +1 more source
Pa-AGOG, the founding member of a new family of archaeal 8-oxoguanine DNA-glycosylases [PDF]
Oxidative damage represents a major threat to genomic stability, as the major product of DNA oxidation, 8-oxoguanine (GO), frequently mispairs with adenine during replication.
Hunziker, P. +4 more
core
Actinomyces spp. gene expression in root caries lesions [PDF]
Background: studies of the distribution of Actinomyces spp. on carious and non-carious root surfaces have not been able to confirm the association of these bacteria with root caries, although they were extensively implicated as a prime suspect in root ...
Damé-Teixeira, N +5 more
core +2 more sources
Microbial metabolites in tumor epigenetic regulation
The gut microbiome modulates tumor epigenetic regulation through bioactive metabolites derived from dietary substrates. Microbiota‐produced SCFAs, secondary BAs, one‐carbon metabolites, and tryptophan‐derived ligands regulate histone acetylation, DNA methylation, and chromatin remodeling via HDAC, DNMT, AhR, and metabolic cofactor‐dependent pathways ...
Wangzheqi Zhang +31 more
wiley +1 more source
Comparative RNA-Seq based dissection of the regulatory networks and environmental stimuli underlying Vibrio parahaemolyticus gene expression during infection [PDF]
Vibrio parahaemolyticus is the leading worldwide cause of seafood-associated gastroenteritis, yet little is known regarding its intraintestinal gene expression or physiology.
Davis, Brigid M. +5 more
core +1 more source
Ricin, a potent ribosome‐inactivating protein derived from the seeds of Ricinus communis L., represents a significant threat in the context of biological warfare and terrorism due to its high toxicity, ease of extraction, and lack of a specific antidote.
Miroslav Pohanka +1 more
wiley +1 more source
Effect of Pyrolysis on the Removal of Antibiotic Resistance Genes and Class I Integrons from Municipal Wastewater Biosolids [PDF]
Wastewater biosolids represent a significant reservoir of antibiotic resistance genes (ARGs). While current biosolids treatment technologies can reduce ARG levels in residual wastewater biosolids, observed removal rates vary substantially.
Kappell, Anthony D. +2 more
core +1 more source

